Forward or backward, that is the question: phospholipid trafficking by the Mla system [0.03%]
向前或向后，这是个问题：Mla系统介导的磷脂转运
Javier Abellon-Ruiz
Javier Abellon-Ruiz
The distinctive feature of Gram-negative bacteria is the presence of an asymmetric outer membrane (OM), which acts as a permeation barrier blocking the diffusion of noxious components such as antibiotics that could compromise cell survival....
Sarah Bastyans,Simon Jackson,Gyorgy Fejer
Sarah Bastyans
Micro and nanosize plastic polymers degrading from large plastic compounds are accumulating in the natural environment and expose potential biological threats to human health. These particles are largely persistent and consequently accumula...
Plastic pollution requires an integrative systems approach to understand and mitigate risk [0.03%]
理解并缓解塑料污染风险需要一个整合的系统方法
Winnie Courtene-Jones,Nathaniel J Clark,Richard C Thompson
Winnie Courtene-Jones
To date, much effort has been placed on quantifying plastic pollution and understanding its negative environmental effects, arguably to the detriment of research and evaluation of potential interventions. This has led to piecemeal progress ...
Winnie Courtene-Jones,Nathaniel J Clark,Richard C Thompson
Winnie Courtene-Jones
Plastics are incredibly versatile materials that can bring diverse societal and environmental benefit, yet current practices of production, use and disposal have negative effects on wildlife, the environment and human health leading to grow...
The bed nucleus of the stria terminalis in threat detection: task choice and rodent experience [0.03%]
终纹床核在威胁检测中的作用：任务选择和啮齿动物经验
Emily R Sherman,Jasmine J Thomas,Emma N Cahill
Emily R Sherman
Behavioural reactivity to potential threat is used to experimentally refine models of anxiety symptoms in rodents. We present a short review of the literature tying the most commonly used tasks to model anxiety symptoms to functional recrui...
The importance of a multidimensional approach to the preclinical study of major depressive disorder and apathy [0.03%]
重度抑郁症和冷漠症临床前研究中多维度方法重要性
Megan G Jackson,Emma S J Robinson
Megan G Jackson
Both the neuropsychiatric syndrome of apathy and major depressive disorder comprise a heterogenous cluster of symptoms which span multiple behavioural domains. Despite this heterogeneity, there is a tendency in the preclinical literature to...
Benjamin Z Roberts,Jared W Young
Benjamin Z Roberts
Cognitive dysfunction, particularly attentional impairment, is a core feature of many psychiatric disorders, yet is inadequately addressed by current treatments. Development of targeted therapeutics for the remediation of attentional defici...
Artificial cell design: reconstructing biology for life science applications [0.03%]
人工细胞设计：为了生命科学应用重构生物系统
Basusree Ghosh
Basusree Ghosh
Artificial cells are developed to redesign novel biological functions in a programmable and tunable manner. Although it aims to reconstitute living cell features and address 'origin of life' related questions, rapid development over the yea...
Gawsia Wahidunnessa Chowdhury,Heather J Koldewey,Md Nazmul Hasan Niloy et al.
Gawsia Wahidunnessa Chowdhury et al.
Assessing three interlinked issues, plastic pollution, climate change and biodiversity loss separately can overlook potential interactions that may lead to positive or negative impacts on global ecosystem processes. Recent studies suggest t...
Negative valence system as a relevant domain in compulsivity: review in a preclinical model of compulsivity [0.03%]
负价系统作为冲动行为相关领域：一项关于强迫性的临床前模型的回顾
Margarita Moreno-Montoya,Manuela Olmedo-Córdoba,Elena Martín-González
Margarita Moreno-Montoya
Compulsive behavior is observed in different neuropsychiatric disorders such as Obsessive-Compulsive Disorder (OCD), anxiety, phobia, schizophrenia and addiction. Compulsivity has been proposed as a transdiagnostic symptom, where the Resear...