Toshihide Kobayashi
Toshihide Kobayashi
Our knowledge on the asymmetric distribution of sphingomyelin (SM) in the plasma membrane is largely based on the biochemical analysis of erythrocytes using sphingomyelinase (SMase). However, recent studies showed that the product of SMase,...
Close, but not too close: a mesoscopic description of (a)symmetry and membrane shaping mechanisms [0.03%]
接近但不接近：介观描述对（非）对称性和膜塑造机制的解释
Victoria Thusgaard Ruhoff,Poul Martin Bendix,Weria Pezeshkian
Victoria Thusgaard Ruhoff
Biomembranes are fundamental to our understanding of the cell, the basic building block of all life. An intriguing aspect of membranes is their ability to assume a variety of shapes, which is crucial for cell function. Here, we review vario...
Visualizing lipid membrane structure with cryo-EM: past, present, and future [0.03%]
用冷冻电镜观察脂质膜结构：过去、现在与未来
Karan D Sharma,Frederick A Heberle,M Neal Waxham
Karan D Sharma
The development of electron cryomicroscopy (cryo-EM) has evolved immensely in the last several decades and is now well-established in the analysis of protein structure both in isolation and in their cellular context. This review focuses on ...
Richard Villagrana,Rosa Laura López-Marqués
Richard Villagrana
Many biological membranes present an asymmetric lipid distribution between the two leaflets that is known as the transbilayer lipid asymmetry. This asymmetry is essential for cell survival and its loss is related to apoptosis. In mammalian ...
Kohjiro Nagao,Masato Umeda
Kohjiro Nagao
In mammalian cells, phospholipids are asymmetrically distributed between the outer and inner leaflets of the plasma membrane. The maintenance of asymmetric phospholipid distribution has been demonstrated to be required for a wide range of c...
Exploring the realm of soft matter biophysics: an early career perspective [0.03%]
探索软物质生物物理学领域：早期职业视角
Natasha H Rhys
Natasha H Rhys
This special issue of Emerging Topics in Life Sciences presents a selection of reviews that give insight into the vast array of research taking place in the fields of soft matter and biophysics, and where these two intersect. The reviews he...
Scratching beyond the surface - minimal actin assemblies as tools to elucidate mechanical reinforcement and shape change [0.03%]
超越表面的刮擦 - 最小肌动蛋白集合作为工具来阐明机械强化和形状变化
Anders Aufderhorst-Roberts,Margarita Staykova
Anders Aufderhorst-Roberts
The interaction between the actin cytoskeleton and the plasma membrane in eukaryotic cells is integral to a large number of functions such as shape change, mechanical reinforcement and contraction. These phenomena are driven by the architec...
Yuting Huang
Yuting Huang
Asymmetric unilamellar vesicles are aqueous bodies surrounded by two dissimilar leaflets made from lipids, polymers, or both. They are great models for cell membranes and attractive vehicles in potential biomedicine applications. Despite th...
Editorial introduction: animal models relevant to mental health disorders [0.03%]
编者按介绍：与精神健康障碍相关的动物模型研究
Amy L Milton
Amy L Milton
Mental health disorders affect a substantial proportion of the worldwide population, and currently available treatments do not work for all affected individuals. Understanding the psychological and biological mechanisms that underlie mental...
Assessing episodic memory in rodents using spontaneous object recognition tasks [0.03%]
利用自发物体识别任务评价啮齿类动物的场景记忆
Flávio Freitas Barbosa,Rochele Castelo-Branco
Flávio Freitas Barbosa
Models of episodic memory are successfully established using spontaneous object recognition tasks in rodents. In this review, we present behavioral techniques devised to investigate this type of memory, emphasizing methods based on associat...