Maria M Krasilnikova,Casey L Humphries,Emily M Shinsky
Maria M Krasilnikova
Friedreich ataxia (FRDA) is an inherited disease that is typically caused by GAA repeat expansion within the first intron of the FXN gene coding for frataxin. This results in the frataxin deficiency that affects mostly muscle, nervous, and ...
The molecular mechanisms of spinocerebellar ataxias for DNA repeat expansion in disease [0.03%]
脊髓小脑共济失调症中DNA重复序列扩增的致病分子机制
Manish Kumar,Nishu Tyagi,Mohammed Faruq
Manish Kumar
Spinocerebellar ataxias (SCAs) are a heterogenous group of neurodegenerative disorders which commonly inherited in an autosomal dominant manner. They cause muscle incoordination due to degeneration of the cerebellum and other parts of nervo...
Mary Anne Panoyan,Frank R Wendt
Mary Anne Panoyan
The human genome contains numerous genetic polymorphisms contributing to different health and disease outcomes. Tandem repeat (TR) loci are highly polymorphic yet under-investigated in large genomic studies, which has prompted research effo...
Dinner date: Neisseria gonorrhoeae central carbon metabolism and pathogenesis [0.03%]
格兰氏阴性菌淋球菌的中心碳代谢与致病性之间的关系
Aimee D Potter,Alison K Criss
Aimee D Potter
Neisseria gonorrhoeae, the causative agent of the sexually transmitted infection gonorrhea, is a human-adapted pathogen that does not productively infect other organisms. The ongoing relationship between N. gonorrhoeae and the human host is...
The power and challenge of lipid (a)symmetry across the membrane and cell [0.03%]
膜和细胞中脂质（非）对称性的力量与挑战
Mikhail Bogdanov
Mikhail Bogdanov
Membrane asymmetry means that the two sides of membrane are structurally, physically and functionally different. Membrane asymmetry is largely related to the lipid sidedness and particularly to compositional (lipid head and acyl group) and ...
Renovating a double fence with or without notifying the next door and across the street neighbors: why the biogenic cytoplasmic membrane of Gram-negative bacteria display asymmetry? [0.03%]
告知隔墙和街对面的邻居就栅栏翻新事宜进行商讨：为什么革兰氏阴性菌的生物发生胞浆膜具有不对称性？
Mikhail Bogdanov
Mikhail Bogdanov
The complex two-membrane organization of the envelope of Gram-negative bacteria imposes an unique biosynthetic and topological constraints that can affect translocation of lipids and proteins synthesized on the cytoplasm facing leaflet of t...
Out-of-plane deformability and its coupling with electrostatics in biomembranes [0.03%]
生物膜的偏离平面变形及其与静电力的耦合
Natalia Wilke,Dayane S Alvares
Natalia Wilke
Cell membranes are quasi-bidimensional soft systems formed by multipoles in an ordered array that can be polarized in an electric field. Consequently, electrostatic potentials emerge inside membranes, and membranes respond to external elect...
Jennifer Hosmer,Alastair G McEwan,Ulrike Kappler
Jennifer Hosmer
Short-chain fatty acids are known modulators of host-microbe interactions and can affect human health, inflammation, and outcomes of microbial infections. Acetate is the most abundant but least well-studied of these modulators, with most st...
Samuel L Foley,Malavika Varma,Amirali Hossein et al.
Samuel L Foley et al.
Many cellular lipid bilayers consist of leaflets that differ in their lipid composition - a non-equilibrium state actively maintained by cellular sorting processes that counter passive lipid flip-flop. While this lipidomic aspect of membran...
The enemy within: lipid asymmetry in intracellular parasite-host interactions [0.03%]
寄生虫细胞内的敌人：脂质不对称性在内共生中的作用
Merryn Fraser,Kai Matuschewski,Alexander G Maier
Merryn Fraser
Eukaryotic pathogens with an intracellular parasitic lifestyle are shielded from extracellular threats during replication and growth. In addition to many nutrients, parasites scavenge host cell lipids to establish complex membrane structure...