Luke Simpson,Ramiro Alberio
Luke Simpson
Gastrulation represents a pivotal phase of development and aberrations during this period can have major consequences, from minor anatomical deviations to severe congenital defects. Animal models are used to study gastrulation, however, the...
Nanobiosensors and nanoformulations in agriculture: new advances and challenges for sustainable agriculture [0.03%]
农业中的纳米生物传感器和纳米配方：可持续农业的新进展与挑战
Cristina Miguel-Rojas,Alejandro Pérez-de-Luque
Cristina Miguel-Rojas
In the current scenario of climate change, global agricultural systems are facing remarkable challenges in order to increase production, while reducing the negative environmental impact. Nano-enabled technologies have the potential to revol...
Rodomiro Ortiz
Rodomiro Ortiz
The genetic improvement of crops faces the significant challenge of feeding an ever-increasing population amidst a changing climate, and when governments are adopting a 'more with less' approach to reduce input use. Plant breeding has the p...
Mark J P Chaisson,Arvis Sulovari,Paul N Valdmanis et al.
Mark J P Chaisson et al.
Long-read sequencing platforms provide unparalleled access to the structure and composition of all classes of tandemly repeated DNA from STRs to satellite arrays. This review summarizes our current understanding of their organization within...
Challenges facing repeat expansion identification, characterisation, and the pathway to discovery [0.03%]
重复扩张面临的挑战及其鉴定、表征和发现途径
Justin L Read,Kayli C Davies,Genevieve C Thompson et al.
Justin L Read et al.
Tandem repeat DNA sequences constitute a significant proportion of the human genome. While previously considered to be functionally inert, these sequences are now broadly accepted as important contributors to genetic diversity. However, the...
Insights into common fragile site instability: DNA replication challenges at DNA repeat sequences [0.03%]
揭秘染色体脆弱位点的不稳定性：DNA重复序列对DNA复制挑战的应对机制研究
Michal Irony-Tur Sinai,Batsheva Kerem
Michal Irony-Tur Sinai
Common fragile sites (CFS) are specific genomic regions prone to chromosomal instability under conditions of DNA replication stress. CFSs manifest as breaks, gaps, and constrictions on metaphase chromosomes under mild replication stress. Th...
Sangeerthana Rajagopal,Jasmine Donaldson,Michael Flower et al.
Sangeerthana Rajagopal et al.
Repeat expansion disorders (REDs) are monogenic diseases caused by a sequence of repetitive DNA expanding above a pathogenic threshold. A common feature of the REDs is a strong genotype-phenotype correlation in which a major determinant of ...
Gastruloid optimization [0.03%]
优化类胚体诱导条件
Lara Avni,Naama Farag,Binita Ghosh et al.
Lara Avni et al.
The young field of gastruloids brings promise to modeling and understanding early embryonic development. However, being a complex model, gastruloids are prone to variability at different levels. In this perspective, we define the different ...
Unravelling the link between neurodevelopmental disorders and short tandem CGG-repeat expansions [0.03%]
解开神经发育障碍和短串联CGG重复扩张之间联系的谜题
Dale J Annear,R Frank Kooy
Dale J Annear
Neurodevelopmental disorders (NDDs) encompass a diverse group of disorders characterised by impaired cognitive abilities and developmental challenges. Short tandem repeats (STRs), repetitive DNA sequences found throughout the human genome, ...
Detection and discovery of repeat expansions in ataxia enabled by next-generation sequencing: present and future [0.03%]
下一代测序在小脑萎缩重复序列检测与发现中的应用：现状和未来展望
Haloom Rafehi,Mark F Bennett,Melanie Bahlo
Haloom Rafehi
Hereditary cerebellar ataxias are a heterogenous group of progressive neurological disorders that are disproportionately caused by repeat expansions (REs) of short tandem repeats (STRs). Genetic diagnosis for RE disorders such as ataxias ar...