Emma Silvester,Lindsay A Baker
Emma Silvester
Electron cryotomography enables the direct visualisation of biological specimens without stains or fixation, revealing complex molecular landscapes at high resolution. However, identifying specific proteins within these crowded environments...
Sleep and memory consolidation in healthy, neurotypical children, and adults: a summary of systematic reviews and meta-analyses [0.03%]
儿童及成人睡眠与记忆巩固：系统评价和荟萃分析述评
Anna Weighall,Ian Kellar
Anna Weighall
This review systematically assesses the impact of sleep on memory and cognition in healthy individuals across different life stages. It specifically examines how sleep affects memory processes in children, adults, and older adults. The meth...
Matthew J Sullivan,Ignacio Terán,Kelvin G K Goh et al.
Matthew J Sullivan et al.
Metal ions such as zinc and copper play important roles in host-microbe interactions and their availability can drastically affect the survival of pathogenic bacteria in a host niche. Mechanisms of metal homeostasis protect bacteria from st...
Metalloproteome plasticity - a factor in bacterial pathogen adaptive responses? [0.03%]
金属蛋白质组的可塑性-细菌病原体适应性反应的一个因素？
Alastair G McEwan
Alastair G McEwan
Through homeostatic processes, bacterial cells maintain intracytoplasmic metal ions at concentrations which enable the 'correct' metal to be inserted into an enzyme, thereby ensuring function. However, fluctuations in intracytoplasmic metal...
Nicola Read,Callum Jennings,Alanna Hare
Nicola Read
Obstructive sleep apnoea-hypopnoea syndrome (OSAHS) is a common disorder characterised by repetitive episodes of the complete or partial collapse of the pharyngeal airway during sleep. This results in cessation (apnoea) or reduction (hypopn...
Caroline L Horton
Caroline L Horton
Until recently, understanding the neurobiology of dreaming has relied upon on correlating a subjective dream report with a measure of brain activity or function sampled from a different occasion. As such, most assumptions about dreaming com...
Chaitanya Dingare,Ben Steventon
Chaitanya Dingare
Metabolic networks are well placed to orchestrate the coordination of multiple cellular processes associated with embryonic development such as cell growth, proliferation, differentiation and cell movement. Here, we discuss the advantages t...
Haematopoietic development and HSC formation in vitro: promise and limitations of gastruloid models [0.03%]
造血发育和HSC体外形成：胚胎样模型的前景与局限性
Liza Dijkhuis,Ayona Johns,Denise Ragusa et al.
Liza Dijkhuis et al.
Haematopoietic stem cells (HSCs) are the most extensively studied adult stem cells. Yet, six decades after their first description, reproducible and translatable generation of HSC in vitro remains an unmet challenge. HSC production in vitro...
Copper management strategies in obligate bacterial symbionts: balancing cost and benefit [0.03%]
专性细菌内共生菌的铜管理策略：权衡成本与收益
Alex Rivera-Millot,Luke B Harrison,Frédéric J Veyrier
Alex Rivera-Millot
Bacteria employ diverse mechanisms to manage toxic copper in their environments, and these evolutionary strategies can be divided into two main categories: accumulation and rationalization of metabolic pathways. The strategies employed depe...
Expanding horizons of tandem repeats in biology and medicine: Why 'genomic dark matter' matters [0.03%]
生物和医学中的串联重复序列研究展望：为什么“基因组暗物质”很重要
Anthony J Hannan
Anthony J Hannan
Approximately half of the human genome includes repetitive sequences, and these DNA sequences (as well as their transcribed repetitive RNA and translated amino-acid repeat sequences) are known as the repeatome. Within this repeatome there a...