Penelope R Haddrill
Penelope R Haddrill
The analysis of DNA from biological evidence recovered in the course of criminal investigations can provide very powerful evidence when a recovered profile matches one found on a DNA database or generated from a suspect. However, when no pr...
An overview of the recent advances in cryo-electron microscopy for life sciences [0.03%]
生命科学中的冷冻电子显微术最新进展综述
Anshul Assaiya,Ananth Prasad Burada,Surbhi Dhingra et al.
Anshul Assaiya et al.
Cryo-electron microscopy (CryoEM) has superseded X-ray crystallography and NMR to emerge as a popular and effective tool for structure determination in recent times. It has become indispensable for the characterization of large macromolecul...
Technologies enabling rapid crop improvements for sustainable agriculture: example pennycress (Thlaspi arvense L.) [0.03%]
可持续农业快速作物改良技术——雷索兰（Thlaspi arvense L.）为例
M David Marks,Ratan Chopra,John C Sedbrook
M David Marks
Growing concerns over food insecurity and ecosystems health related to population growth and climate change have challenged scientists to develop new crops, employing revolutionary technologies in combination with traditional methods. In th...
Evolution of biophysical tools for quantitative protein interactions and drug discovery [0.03%]
定量蛋白质相互作用和药物发现的生物物理工具的发展
Mahalakshmi Harish,Prasanna Venkatraman
Mahalakshmi Harish
With millions of signalling events occurring simultaneously, cells process a continuous flux of information. The genesis, processing, and regulation of information are dictated by a huge network of protein interactions. This is proven by th...
Gonçalo Silva,Jenny Tomlinson,Nawaporn Onkokesung et al.
Gonçalo Silva et al.
Plant pests and diseases impact both food security and natural ecosystems, and the impact has been accelerated in recent years due to several confounding factors. The globalisation of trade has moved pests out of natural ranges, creating da...
Mass spectrometry based untargeted metabolomics for plant systems biology [0.03%]
基于质谱的非目标代谢组学在植物系统生物学中的应用
Sophie Alvarez,Michael J Naldrett
Sophie Alvarez
Untargeted metabolomics enables the identification of key changes to standard pathways, but also aids in revealing other important and possibly novel metabolites or pathways for further analysis. Much progress has been made in this field ov...
Studying protein folding in health and disease using biophysical approaches [0.03%]
运用生物物理方法研究蛋白质折叠在健康和疾病中的作用
Hong Zhang,Weibin Gong,Si Wu et al.
Hong Zhang et al.
Protein folding is crucial for normal physiology including development and healthy aging, and failure of this process is related to the pathology of diseases including neurodegeneration and cancer. Early thermodynamic and kinetic studies ba...
Affinity maturation: highlights in the application of in vitro strategies for the directed evolution of antibodies [0.03%]
亲和力成熟：体外策略在抗体定向进化中的应用要点
Denice T Y Chan,Maria A T Groves
Denice T Y Chan
Affinity maturation is a key technique in protein engineering which is used to improve affinity and binding interactions in vitro, a process often required to fulfil the therapeutic potential of antibodies. There are many available display ...
High-throughput image segmentation and machine learning approaches in the plant sciences across multiple scales [0.03%]
高通量图像分割及植物科学研究中的机器学习方法
Eli Buckner,Haonan Tong,Chanae Ottley et al.
Eli Buckner et al.
Agriculture has benefited greatly from the rise of big data and high-performance computing. The acquisition and analysis of data across biological scales have resulted in strategies modeling inter- actions between plant genotype and environ...
Tracing plant-environment interactions from organismal to planetary scales using stable isotopes: a mini review [0.03%]
利用稳定同位素从有机体到全球尺度研究植物-环境相互作用的进展：小结性评论文章
Gavin McNicol,Zhongjie Yu,Z Carter Berry et al.
Gavin McNicol et al.
Natural isotope variation forms a mosaic of isotopically distinct pools across the biosphere and flows between pools integrate plant ecology with global biogeochemical cycling. Carbon, nitrogen, and water isotopic ratios (among others) can ...