The future of immune checkpoint combinations with tumor-targeted small molecule drugs [0.03%]
免疫检查点与靶向小分子药物联合治疗的未来趋势分析
Jaclyn Sceneay,Charles Sinclair
Jaclyn Sceneay
Immune-checkpoint blockade (ICB) has transformed the landscape of cancer treatment. However, there is much to understand around refractory or acquired resistance in patients in order to utilize ICB therapy to its full potential. In this per...
Derry K Mercer,Marie-Louise Francis,Douglas Fraser-Pitt
Derry K Mercer
In this age of antimicrobial resistance (AMR) there is an urgent need for novel antimicrobials. One area of recent interest is in developing antimicrobial effector molecules, and even cell-based therapies, based on those of the immune syste...
Davide Vincenzo Verdolino,Helen A Thomason,Andrea Fotticchia et al.
Davide Vincenzo Verdolino et al.
Chronic wounds represent an economic burden to healthcare systems worldwide and a societal burden to patients, deeply impacting their quality of life. The incidence of recalcitrant wounds has been steadily increasing since the population mo...
Interpretation of DNA data within the context of UK forensic science - investigation [0.03%]
英国法医调查中DNA数据的解读
Susan Pope,Roberto Puch-Solis
Susan Pope
This article is the second part of a review of the interpretation of DNA data in forensic science. The first part describes the evaluation of autosomal profile for criminal trials where an evidential weight is assigned to the profile of a p...
William Woods,Daisy Evans,Aina Mogas Barcons et al.
William Woods et al.
Injuries to the brain and spinal cord have major clinical consequences with high costs for healthcare systems. Neural cell transplantation therapies have significant translational potential to promote regeneration post-injury with clinical ...
Interpretation of DNA data within the context of UK forensic science - evaluation [0.03%]
英国法医背景下DNA数据的解读-评估报告
Roberto Puch-Solis,Susan Pope
Roberto Puch-Solis
Forensic DNA provides a striking contribution to the provision of justice worldwide. It has proven to be crucial in the investigative phase of an unsolved crime where a suspect needs to be identified, e.g. from a DNA database search both na...
Douglas Fraser-Pitt,Derry Mercer
Douglas Fraser-Pitt
The aminothiol cysteamine has many potential therapeutic applications and is also an endogenous molecule, produced in the body via the activity of pantetheinase enzymes such as vanin-1. This simple small molecule is highly reactive in biolo...
Christopher N Topp,Joseph M Jez
Christopher N Topp
In recent years, an array of new technologies is propelling plant science in exciting directions and facilitating the integration of data across multiple scales. These tools come at a critical time. With an expanding global population and t...
Recent developments and potential of robotics in plant eco-phenotyping [0.03%]
植物表型组学中机器人技术的最新进展和应用前景
Lili Yao,Rick van de Zedde,George Kowalchuk
Lili Yao
Automated acquisition of plant eco-phenotypic information can serve as a decision-making basis for precision agricultural management and can also provide detailed insights into plant growth status, pest management, water and fertilizer mana...
Rob Ogden,Nina Vasiljevic,Stefan Prost
Rob Ogden
The past decade has seen a rapid expansion of non-human forensic genetics coinciding with the development of 2nd and 3rd generation DNA sequencing technologies. Nanopore sequencing is one such technology that offers massively parallel seque...