Single nucleus RNA-sequencing: how it's done, applications and limitations [0.03%]
单细胞核RNA测序：操作方法、应用和局限性
Juliane Fischer,Thomas Ayers
Juliane Fischer
Single nuclei RNA-sequencing (sNuc-Seq) is a methodology which uses isolated nuclei instead of whole cells to profile gene expression. By using droplet microfluidic technologies, users are able to profile thousands of single transcriptomes ...
Practical considerations for delivering on the sustainability promise of fermentation-based biomanufacturing [0.03%]
发酵基生物制造实现可持续性的实际考虑因素
David Lips
David Lips
Increasingly, bio-based products made via sugar-powered microbial cell factories and industrial fermentation are reaching the market and presenting themselves as sustainable alternatives to fossil and animal-based products. The sustainabili...
Jonathan D Moore
Jonathan D Moore
Our hopes of using the power of the immune system to control tumours have been partially fulfilled with anti-PD1 antibodies and other checkpoint inhibitors and the use of engineered T cells targeting lineage-specific surface markers with ch...
Mesenchymal stromal cells: what have we learned so far about their therapeutic potential and mechanisms of action? [0.03%]
间充质基质细胞：我们对它们的治疗潜力和作用机制了解多少？
Francesco Amadeo,Katherine Trivino Cepeda,James Littlewood et al.
Francesco Amadeo et al.
Mesenchymal stromal cells (MSCs) have been found to be safe and effective in a wide range of animal models of human disease. MSCs have been tested in thousands of clinical trials, but results show that while these cells appear to be safe, t...
Epigenetic features in regulation of telomeres and telomerase in stem cells [0.03%]
表观遗传特征在干细胞端粒和端粒酶调控中的作用
Fatma Dogan,Nicholas R Forsyth
Fatma Dogan
The epigenetic nature of telomeres is still controversial and different human cell lines might show diverse histone marks at telomeres. Epigenetic modifications regulate telomere length and telomerase activity that influence telomere struct...
Claire E Stewart
Claire E Stewart
The estimated cost of acute injuries in college-level sport in the USA is ∼1.5 billion dollars per year, without taking into account the cost of follow up rehabilitation. In addition to this huge financial burden, without appropriate diagn...
Charlotte H Hulme,Jade Perry,Helen S McCarthy et al.
Charlotte H Hulme et al.
Regenerative medicine, using cells as therapeutic agents for the repair or regeneration of tissues and organs, offers great hope for the future of medicine. Cell therapy for treating defects in articular cartilage has been an exemplar of tr...
Remyelination: what are the prospects for regenerative therapies in multiple sclerosis? [0.03%]
少突胶质细胞再生：多发性硬化修复治疗的希望？
Jonathan D Moore
Jonathan D Moore
Multiple sclerosis (MS) involves the immune system attacking the myelin sheaths surrounding axons and is a major cause of disability in working-age adults. Various approved therapies now provide reasonably good control over MS neuroinflamma...
Lucina Hackman,Niamh Nic Daeid
Lucina Hackman
In recent decades the use of forensic science in investigations and therefore its subsequent presentation within the courts has increased exponentially, fuelled by an increase in scientific advances, development of databases and greater acc...
ImmTORTM to amplify the efficacy and reduce immunogenicity of biologics [0.03%]
ImmTORTM技术可放大生物药疗效并降低免疫原性
Carsten Brunn,Takashi Kei Kishimoto
Carsten Brunn
In recent months as vaccines against the SARS-CoV-2 virus continue to rollout across the globe, there has been a renewed interest in ways to activate or ignite the immune system. For a vaccine to be effective, it must be immunogenic and spe...