Molecular-based precision oncology clinical decision making augmented by artificial intelligence [0.03%]
基于分子的precision oncology临床决策可由人工智能增强
Jia Zeng,Md Abu Shufean
Jia Zeng
The rapid growth and decreasing cost of Next-generation sequencing (NGS) technologies have made it possible to conduct routine large panel genomic sequencing in many disease settings, especially in the oncology domain. Furthermore, it is no...
It takes guts to learn: machine learning techniques for disease detection from the gut microbiome [0.03%]
从肠道微生物组检测疾病的机器学习技术需要勇气去学习
Kristen D Curry,Michael G Nute,Todd J Treangen
Kristen D Curry
Associations between the human gut microbiome and expression of host illness have been noted in a variety of conditions ranging from gastrointestinal dysfunctions to neurological deficits. Machine learning (ML) methods have generated promis...
Manufacturing of AAV vectors: translational challenges from development to industrialisation [0.03%]
AAV载体的生产：从研发到工业化的转化挑战
Tony Hitchcock
Tony Hitchcock
AAV mediated gene therapy offers the potential for curative therapies for many fatal and debilitating diseases, however the translation of these concepts into licenced products is stymied by manufacturing challenges leading to very high cos...
Damien Weidmann,Richard Kovacich,Robert Gibbs et al.
Damien Weidmann et al.
Trace gas analysis provides a wide range of insights into environmental processes, particularly with regards to global warming and air quality. With the urgent need to identify sources and accurately measure the harmful emissions negatively...
Targetable nano-delivery vehicles to deliver anti-bacterial small acid-soluble spore protein (SASP) genes [0.03%]
可靶向的纳米输送工具来传递抗细菌的小酸溶性孢子蛋白(SASP)基因
Anne M L Barnard,James A Cass
Anne M L Barnard
Interest in phage-based therapeutics is increasing, at least in part due to the need for new treatment options for infections caused by antibiotic-resistant bacteria. It is possible to use wild-type (WT) phages to treat bacterial infections...
Romanos Fasoulis,Georgios Paliouras,Lydia E Kavraki
Romanos Fasoulis
The field of structural proteomics, which is focused on studying the structure-function relationship of proteins and protein complexes, is experiencing rapid growth. Since the early 2000s, structural databases such as the Protein Data Bank ...
Current topics in stem cell biology and regenerative medicine: a regional perspective from the United Kingdom [0.03%]
干细胞生物学与再生医学的当前议题：来自英国的区域视角
William Eustace Johnson
William Eustace Johnson
This special issue of Emerging Topics in Life Sciences entitled 'Current Topics in Stem Cells and Regenerative Medicine' brings together expertise from a collaborative organisation known as the Mercia Stem Cell Alliance (MSCA). The alliance...
James Birch,Andrew Quigley
James Birch
Membrane proteins, found at the junctions between the outside world and the inner workings of the cell, play important roles in human disease and are used as biosensors. More than half of all therapeutics directly affect membrane protein fu...
Denise Syndercombe Court
Denise Syndercombe Court
Originally relatively ignored in forensic investigations because its genetic analysis lacks inference of individual identification, the value of Y chromosome analysis has been proven in cases of sexual assault, particularly where the amount...
Modelling the central nervous system: tissue engineering of the cellular microenvironment [0.03%]
中枢神经系统的建模：细胞微环境的组织工程
Paige A Walczak,Patricia Perez-Esteban,David C Bassett et al.
Paige A Walczak et al.
With the increasing prevalence of neurodegenerative diseases, improved models of the central nervous system (CNS) will improve our understanding of neurophysiology and pathogenesis, whilst enabling exploration of novel therapeutics. Studies...