Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action [0.03%]
天然及合成糖基疫苗佐剂及其作用机制
Carlo Pifferi,Roberto Fuentes,Alberto Fernández-Tejada
Carlo Pifferi
Modern subunit vaccines based on homogeneous antigens offer more precise targeting and improved safety compared with traditional whole-pathogen vaccines. However, they are also less immunogenic and require an adjuvant to increase the immuno...
Dirhodium tetracarboxylates as catalysts for selective intermolecular C-H functionalization [0.03%]
二铑四羧酸酯用作选择性分子间C-H功能化的催化剂
Huw M L Davies,Kuangbiao Liao
Huw M L Davies
C-H Functionalization has become widely recognized as an exciting new strategy for the synthesis of complex molecular targets. Instead of relying on functional groups as the controlling elements of how molecules are assembled, it offers a t...
Willem A Velema,Eric T Kool
Willem A Velema
RNA is a versatile biomolecule with a broad range of biological functions that go far beyond its initially described role as a simple information carrier. The development of chemical methods to control, manipulate and modify RNA has the pot...
Controlling the optical properties of carbon nanotubes with organic colour-centre quantum defects [0.03%]
使用有机中心色心量子缺陷来控制碳纳米管的光学特性
Alexandra H Brozena,Mijin Kim,Lyndsey R Powell et al.
Alexandra H Brozena et al.
Previously unwelcome, defects are emerging as a new frontier of research, providing a molecular focal point to study the coupling of electrons, excitons, phonons and spin in low-dimensional materials. This opportunity is particularly intrig...
Thomas A Scott,Jörn Piel
Thomas A Scott
Bacterial natural products display astounding structural diversity, which, in turn, endows them with a remarkable range of biological activities that are of significant value to modern society. Such structural features are generated by bios...
Christian Agatemor,Matthew J Buettner,Ryan Ariss et al.
Christian Agatemor et al.
Metabolic glycoengineering (MGE) is a technique for manipulating cellular metabolism to modulate glycosylation. MGE is used to increase the levels of natural glycans and, more importantly, to install non-natural monosaccharides into glycoco...
Ashok Kakkar,Giovanni Traverso,Omid C Farokhzad et al.
Ashok Kakkar et al.
Designing therapeutics is a process with many challenges. Even if the first hurdle - designing a drug that modulates the action of a particular biological target in vitro - is overcome, selective delivery to that target in vivo presents a m...
Modern applications of low-valent early transition metals in synthesis and catalysis [0.03%]
低 valent 早期过渡金属在合成和催化中的现代应用
Evan P Beaumier,Adam J Pearce,Xin Yi See et al.
Evan P Beaumier et al.
Low-valent early transition metals are often intrinsically highly reactive as a result of their strong propensity toward oxidation to more stable high-valent states. Harnessing these highly reducing complexes for productive reactivity is po...
Multiscale Methods in Drug Design Bridge Chemical and Biological Complexity in the Search for Cures [0.03%]
跨尺度方法在药物设计中的应用：在寻找治疗方法的过程中连接化学和生物复杂性
Rommie E Amaro,Adrian J Mulholland
Rommie E Amaro
Drug action is inherently multiscale: it connects molecular interactions to emergent properties at cellular and larger scales. Simulation techniques at each of these different scales are already central to drug design and development, but m...
Earth-Abundant Transition Metal Catalysts for Alkene Hydrosilylation and Hydroboration: Opportunities and Assessments [0.03%]
基于地球丰富过渡金属的烯烃硅氢化和硼氢化催化剂：机遇与展望
Jennifer V Obligacion,Paul J Chirik
Jennifer V Obligacion
The addition of a silicon-hydrogen or a boron-hydrogen bond across a carbon-carbon multiple bonds is a well-established method for the introduction of versatile silane and borane functional groups to base hydrocarbon feedstocks. Transition ...