Liver resection versus radiofrequency ablation or transarterial chemoembolization for early multinodular BCLC-A hepatocellular carcinoma: a systematic review and meta-analysis [0.03%]
肝切除与射频消融或经导管动脉化疗栓塞治疗巴塞罗那分期BCLC-A期多结节小肝癌：系统评价和 Meta 分析
Maria F F Viana,Arthur A Braga,Lucas B Carvalho et al.
Maria F F Viana et al.
Hepatocellular carcinoma (HCC) is the most common form of liver cancer, with high mortality rates worldwide. The optimal treatment strategy for patients with multinodular early-stage HCC (BCLC-A) is still controversial, particularly regardi...
Surgical Management of Intrahepatic Cholangiocarcinoma and Combined Hepatocellular-Cholangiocarcinoma: A Narrative Review of Principles, Technical Nuances, and Emerging Strategies [0.03%]
肝内胆管癌和混合型肝细胞-胆管癌的外科治疗：原则、技术要点及新兴策略的叙述性回顾
Woohyung Lee,Kwang Pyo Hong,Jae Hoon Lee et al.
Woohyung Lee et al.
Intrahepatic cholangiocarcinoma (CCA) is the second most common primary liver cancer after hepatocellular carcinoma (HCC). However, combined HCC-CCA is a rare malignancy exhibiting hepatocytic and cholangiocytic differentiation. For both tu...
Immune-related adverse events in hepatocellular carcinoma: organ-specific patterns and management approaches [0.03%]
免疫相关不良事件在肝细胞癌中的器官特异性模式和管理方法
Sul Ki Choi,Seonjeong Woo,Hong Jae Chon
Sul Ki Choi
Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality worldwide. The recent introduction of immune checkpoint inhibitors (ICIs) has transformed the therapeutic landscape of advanced HCC. Combination regimens such as at...
Exploring Single-Cell and Multi-Omics Technologies and Their Role in Unravelling Tumor Heterogeneity of Hepatocellular Carcinoma [0.03%]
探究单细胞及多组学技术在解析肝癌肿瘤异质性中的作用
Charmi Jyotishi,Suresh Prajapati,Mansi Patel et al.
Charmi Jyotishi et al.
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Tumor heterogeneity is a major obstacle to effective treatment and is poorly understood using traditional bulk sequencing methods. This review highlights the tr...
Strategic drug sequencing in hepatocellular carcinoma in the era of chemo-diversity: maximizing the therapeutic benefit of lenvatinib [0.03%]
多元化化疗时代肝癌的药物序贯策略：充分运用仑伐替尼的治疗优势
Hideki Iwamoto,Shigeo Shimose,Hironori Koga et al.
Hideki Iwamoto et al.
The emergence of systemic therapies has ushered in an era of chemo-diversity for hepatocellular carcinoma, in which drug sequencing is pivotal for maximizing outcomes. Among available agents, lenvatinib is notable for its potent anti-angiog...
A rare case of IgG4-related sclerosing cholangitis followed by rapid subsequent diagnosis of cholangiocarcinoma [0.03%]
IgG4相关性硬化性胆管炎罕见病例于短期内继发胆管癌诊断
Gordon Hong,Amber Hussain,Eduardo Thadeu de Oliveira Correia et al.
Gordon Hong et al.
IgG4-related sclerosing cholangitis (IgG4-SC) is a rare condition with symptoms often mimicking malignancy, infection, or other autoimmune diseases. This case report describes the unique case of a 62-year-old male initially diagnosed with I...
Case Reports
Journal of liver cancer. 2025 Dec 17. DOI:10.17998/jlc.2025.12.09 2025
PNPLA3 I148M is unrelated to HCC occurrence but associates with poorer tumor differentiation in Korean MASLD: a prospective cohort of 562 patients [0.03%]
PNPLA3 I148M与韩国MASLD患者发生HCC无关，但与较差的肿瘤分化相关：一项针对562名患者的前瞻性队列研究
Jaejun Lee,Dong Yeop Lee,Jung Hoon Cha et al.
Jaejun Lee et al.
Background: The patatin-like phospholipase domain-containing protein 3 (PNPLA3) I148M variant has been implicated in metabolic dysfunction-associated steatotic liver disease (MASLD), but its role in hepatocellular carcino...
Re-evaluating DAA therapy in active hepatocellular carcinoma: from controversy to clinical considerations [0.03%]
重新评估DAAs治疗活跃期肝细胞癌：从争议到临床考量
So Hyun Jeon,Jeong-Ju Yoo,Sang Gyune Kim et al.
So Hyun Jeon et al.
Direct-acting antiviral (DAA) therapy has brought a revolution to the management of chronic hepatitis C virus (HCV) infection, but its role in patients with active hepatocellular carcinoma (HCC) remains controversial. Early observations sug...
Bao Le Thai Tran,Ngoc Hong Cao,Tung Hoang
Bao Le Thai Tran
Increasing evidence indicates that metabolites play a significant role in the pathogenesis of liver cancer and have potential as biomarkers for early detection. This review summarizes the current literature on the utility of metabolomic pro...
Surgical treatment of hepatocellular carcinoma: an expert consensus-based practical recommendation from the Korean Liver Cancer Association [0.03%]
肝细胞癌外科治疗实践指南：韩国肝脏肿瘤协会专家共识意见
Min-Su Park,Jai Young Cho,Eunju Kim et al.
Min-Su Park et al.
Compared with other treatments, surgical resection is an effective treatment method with the lowest local recurrence rate and the highest survival rate for hepatocellular carcinoma (HCC). To achieve excellent results after surgical treatmen...