A Low-Level Perceptual Correlate of Behavioral and Clinical Deficits in ADHD [0.03%]
注意缺陷多动障碍的行为和临床缺损的低级感知关联
Andra Mihali,Allison G Young,Lenard A Adler et al.
Andra Mihali et al.
In many studies of attention-deficit hyperactivity disorder (ADHD), stimulus encoding and processing (perceptual function) and response selection (executive function) have been intertwined. To dissociate deficits in these functions, we intr...
A Bayesian Account of Psychopathy: A Model of Lacks Remorse and Self-Aggrandizing [0.03%]
从贝叶斯角度理解精神病：缺乏悔恨和自我夸大的模型
Aaron Prosser,Karl J Friston,Nathan Bakker et al.
Aaron Prosser et al.
This article proposes a formal model that integrates cognitive and psychodynamic psychotherapeutic models of psychopathy to show how two major psychopathic traits called lacks remorse and self-aggrandizing can be understood as a form of abn...
Computation in Psychotherapy, or How Computational Psychiatry Can Aid Learning-Based Psychological Therapies [0.03%]
计算在心理治疗中的作用，或计算精神病学如何助力基于学习的心理疗法
Michael Moutoussis,Nitzan Shahar,Tobias U Hauser et al.
Michael Moutoussis et al.
Learning-based therapies, such as cognitive-behavioral therapy, are used worldwide, and their efficacy is endorsed by health and research funding agencies. However, the mechanisms behind both their strengths and their weaknesses are inadequ...
Perturbing the Hypothalamic-Pituitary-Adrenal Axis: A Mathematical Model for Interpreting PTSD Assessment Tests [0.03%]
扰动下丘脑－垂体－肾上腺轴：解释创伤后应激障碍评估测试的数学模型
Lae Un Kim,Maria R D&#x;Orsogna,Tom Chou
Lae Un Kim
We use a dynamical systems model of the hypothalamic-pituitary-adrenal (HPA) axis to understand the mechanisms underlying clinical protocols used to probe patient stress response. Specifically, we address dexamethasone (DEX) and ACTH challe...
Mechanisms Underlying Dopamine-Induced Risky Choice in Parkinson's Disease With and Without Depression (History) [0.03%]
多巴胺诱导帕金森病伴与不伴有抑郁病史患者的风险决策机制研究
Monique H M Timmer,Guillaume Sescousse,Rianne A J Esselink et al.
Monique H M Timmer et al.
Patients with Parkinson's disease (PD) are often treated with dopaminergic medication. Dopaminergic medication is known to improve both motor and certain nonmotor symptoms, such as depression. However, it can contribute to behavioral impair...
A Bayesian Approach to Modeling Risk of Hospital Admissions Associated With Schizophrenia Accounting for Underdiagnosis of the Disorder in Administrative Records [0.03%]
一种贝叶斯方法，用于根据行政记录中精神分裂症的误诊来计算与精神分裂症相关的住院风险模型
Eileen M Stock,James D Stamey,John E Zeber et al.
Eileen M Stock et al.
Schizophrenia is a debilitating serious mental illness characterized by a complex array of symptoms with varying severity and duration. Patients may seek treatment only intermittently, contributing to challenges diagnosing the disorder. A m...
Kentaro Katahira,Yuichi Yamashita
Kentaro Katahira
One of the major goals of basic studies in psychiatry is to find etiological mechanisms or biomarkers of mental disorders. A standard research strategy to pursue this goal is to compare observations of potential factors from patients with t...
Can Peripheral Blood-Derived Gene Expressions Characterize Individuals at Ultra-high Risk for Psychosis? [0.03%]
外周血基因表达能否用于识别超精神病高危个体？
Wilson Wen Bin Goh,Judy Chia-Ghee Sng,Jie Yin Yee et al.
Wilson Wen Bin Goh et al.
The ultra-high risk (UHR) state was originally conceived to identify individuals at imminent risk of developing psychosis. Although recent studies have suggested that most individuals designated UHR do not, they constitute a distinctive gro...
David Cittern,Abbas Edalat
David Cittern
We build on a neuroanatomical model of how empathic states can motivate caregiving behavior, via empathy circuit-driven activation of regions in the hypothalamus and amygdala, which in turn stimulate a mesolimbic-ventral pallidum pathway, b...
Computational Modeling of Contrast Sensitivity and Orientation Tuning in First-Episode and Chronic Schizophrenia [0.03%]
首发和慢性精神分裂症的对比敏感度和方位特异性的计算模型研究
Steven M Silverstein,Docia L Demmin,James A Bednar
Steven M Silverstein
Computational modeling is a useful method for generating hypotheses about the contributions of impaired neurobiological mechanisms, and their interactions, to psychopathology. Modeling is being increasingly used to further our understanding...