Pediatric oncology as a Learning Health System: Ethical implications for best available treatment protocols [0.03%]
作为学习型医疗系统的儿科肿瘤学：最佳可用治疗方案的伦理意义
Rieke van der Graaf,Sara A Dekking,Martine C de Vries et al.
Rieke van der Graaf et al.
Introduction: Pediatric oncology is often considered as a field in which research and care are highly integrated. We believe that this integration can be seen as a so-called Learning Health System, a system in which resea...
Enhancing knowledge of authorization requests through registry development [0.03%]
通过注册表开发增强对授权请求的了解
Kara L Kuntz-Melcavage,Kyle DeCarlo Gahagan,Mark R Fracasso et al.
Kara L Kuntz-Melcavage et al.
Understanding the member population to which medical coverage policies apply is important for ensuring the relevance of a health insurer's policies. The medical policy unit of our company developed a registry and workflow to enhance our kno...
Stakeholder perspectives regarding alternate approaches to informed consent for comparative effectiveness research [0.03%]
有关非介入性效果研究知情同意的各方观点
Stephanie R Morain,Ellen Tambor,Rachael Moloney et al.
Stephanie R Morain et al.
Introduction: Traditional informed consent approaches, involving separate discussions and lengthy consent forms, may be an imperfect fit for comparative effectiveness research (CER) that is integrated into usual care and ...
The TRANSFoRm project: Experience and lessons learned regarding functional and interoperability requirements to support primary care [0.03%]
TRANSFoRm项目：关于支持初级保健的功能和互操作性需求的经验与教训
Jean-François Ethier,Mark McGilchrist,Adrien Barton et al.
Jean-François Ethier et al.
Introduction: The current model of medical knowledge production, transfer, and application suffers from serious shortcomings. Learning health systems (LHS) have recently emerged as a potential solution-systems in which he...
Addressing the unique healthcare needs of women: Opportunity for change exists at the intersection of precision health and learning health systems [0.03%]
应对女性独特的医疗需求：精准医疗和学习医疗系统的交叉点上存在着变革的机会
Sonya Satveit
Sonya Satveit
Introduction: Women have unique healthcare needs that are not well addressed by our current healthcare system and with healthcare transformation underway the opportunity exists to avoid weaving these age-old problems into...
Jodyn Platt,Kayte Spector-Bagdady,Tevah Platt et al.
Jodyn Platt et al.
Jeffrey R Botkin
Jeffrey R Botkin
Learning healthcare systems rely on potentially sensitive data and biospecimens from patients who typically have no knowledge of secondary uses of these resources for research. While this failure to inform patients of these practices is con...
John D Lantos
John D Lantos
The central philosophical pillar of the current system of research regulation in the United States today is that clinical investigators cannot and should not be trusted to protect the interests of the people whom they recruit to participate...
Ethical issues in pragmatic trials of "standard-of-care" interventions in learning health care systems [0.03%]
学习健康体系中关于“标准护理”干预实用试验的伦理问题
Scott Y H Kim
Scott Y H Kim
Introduction: Learning health care systems (LHS) hold the promise of improving medical care by systematically and continuously integrating the delivery of medical services with clinical research. One important type of int...
Opportunities and barriers for pragmatic embedded trials: Triumphs and tribulations [0.03%]
实用型嵌入式试验的机会与障碍：成功与挫折
Joakim Ramsberg,Richard Platt
Joakim Ramsberg
Results: Embedded pragmatic clinical trials (PCTs) are set in routine health care, have broad eligibility criteria, and use routinely collected electronic data. Many consider them a breakthrough innovation in clinical res...