Moving from a taxonomic to a functional perspective in global microbiome analysis requires optimizing multiplexing ratios [0.03%]
从分类学角度转向功能角度进行全球微生物组分析需要优化复用率
Kinga Zielińska,Kateryna Pantiukh,Elin Org et al.
Kinga Zielińska et al.
Next-generation sequencing has revolutionized microbiome research, yet the transition from taxonomic to functional profiling remains a major technical challenge. While marker gene sequencing provides a widely accessible ecological view, it ...
A large-scale comparative metagenomic analysis of short-read sequencing platforms indicates high taxonomic concordance and functional analysis challenge [0.03%]
大规模比较元基因组分析短读测序平台表明分类学一致性高和功能分析有挑战性
Kinga Zielińska,Kateryna Pantiukh,Pawel P Łabaj et al.
Kinga Zielińska et al.
Driven by the increasing scale of microbiome studies and the rise of large, continuously expanding population cohorts, the volume of sequencing data is growing rapidly. As such, ensuring the comparability of data generated across different ...
Early-life proteomic and microbiome features signal obesity risk across 26 years of follow-up [0.03%]
生命早期的蛋白质和微生物组特征可预测长达26年的肥胖风险
Angelica P Ahrens,Raquel Dias,Tuulia Hyötyläinen et al.
Angelica P Ahrens et al.
Childhood obesity is rising globally. Yet, few studies have examined the microbiome and proteome in early childhood in relation to this outcome, and most are cross-sectional by design. Early-life factors in the ABIS birth cohort (n = 16,683...
The Hungate1000 prokaryotic culture collection encodes a wide variety of bacteriocins [0.03%]
Hungate1000原核生物培养集藏编码多种杀菌蛋白和抗菌肽
David Hourigan,Lorraine Draper,Sinead C Leahy et al.
David Hourigan et al.
Bacteriocins are antimicrobial peptides/proteins that are widely distributed among bacteria and are gathering traction as natural alternatives to antibiotics, modulators of the microbiota, and interbacterial signaling peptides. The Hungate1...
Oliver Lenz
Oliver Lenz
Certain hydrogenases are capable of converting the trace amounts of molecular hydrogen constantly present in Earth's atmosphere to supply cells with a little energy during periods of starvation. Recently, Kropp and colleagues investigated t...
Metagenomic polymorphic toxin effector and immunity profiling predicts microbiome development and disease-related dysbiosis [0.03%]
元基因组多态毒物效应因子和免疫谱分析可预测微生物群发育及与疾病相关的菌群失调
Hunter W Schroer,Francesco Beghini,Juan Antonio Raygoza Garay et al.
Hunter W Schroer et al.
Bacteria use antagonistic interbacterial weapons, such as polymorphic toxin secretion systems (TSS), to compete for niches in the human gut microbiome. We hypothesized that TSS influence gut microbiome development and disease-related dysbio...
Freeze-thaw strength regulates carbon density through microbial assembly processes and network clustering [0.03%]
冻融强度通过微生物组装过程和网络聚类调节碳密度
Shengyun Chen,Enyan Liu,Yuzheng Gu et al.
Shengyun Chen et al.
Freeze-thaw processes profoundly affect soil carbon storage by altering microbial communities. However, the response mechanisms of microbial community properties and their carbon sequestration potential to freeze-thaw patterns remain poorly...
Bacterial supplementation shapes honey bee gut microbiota and host metabolism under controlled and field conditions [0.03%]
一种细菌补充剂可调节意蜂肠道菌群及宿主代谢状态（实验室与田间实验）
Saetbyeol Lee,Pavel Dobes,Anna Mascellani Bergo et al.
Saetbyeol Lee et al.
Gut bacteria are essential to honey bee (Apis mellifera) health, supporting digestion, immunity, and resilience against stressors. Probiotic-based strategies have been proposed to enhance core gut symbionts, yet the underlying mechanisms an...
Mtb-Timer: a fluorescent reporter to visualize Mycobacterium tuberculosis replication and antibiotic responses [0.03%]
Mtb-Timer：一种可视化结核杆菌复制和抗生素反应的荧光报告系统
Víctor Campo-Pérez,Chak Hon Luk,Laure Botella et al.
Víctor Campo-Pérez et al.
Despite the importance of monitoring Mycobacterium tuberculosis (Mtb) replication and antibiotic responses at the single-cell level, available tools to accurately monitor single Mtb replication are limited. Here, we report the development o...
The middle ear-nasopharyngeal microbiome axis associated with obstructive Eustachian tube dysfunction in chronic otitis media [0.03%]
与慢性中耳炎相关阻塞性咽鼓管功能障碍的中耳-鼻咽微生物轴关系研究
Xiaoxin Chen,George Gong Chen,Zhongqin Gong et al.
Xiaoxin Chen et al.
Obstructive Eustachian tube dysfunction (ETD) commonly complicates chronic otitis media (COM), yet microbial factors at the Eustachian tube (ET) openings remain poorly understood. In this prospective cohort study, we characterized the micro...