Harmane induces apoptosis through RRM2B and suppresses colorectal cancer progression [0.03%]
哈曼通过RRM2B诱导凋亡并抑制结直肠癌进展
Guifang Li,Li Li,Peipei Shen et al.
Guifang Li et al.
Colorectal cancer (CRC) is a common malignant tumor of the digestive system, and chemotherapy resistance often leads to poor patient prognosis. Harmane, a natural indole alkaloid, is found in Leguminosae plants (particularly those of the Cr...
Ira J Blader,Ashley Shade
Ira J Blader
Editorial
mSystems. 2026 Jun 9:e0060926. DOI:10.1128/msystems.00609-26 2026
Decoding the interactome for cyclic-di-AMP-producing enzyme diadenylate cyclase [0.03%]
解码环状二腺苷酸产生酶的互作组
Rong Mu,Baotong Xie,Stephanie Momeni et al.
Rong Mu et al.
In many gram-positive bacteria, the diadenylate cyclase DacA synthesizes the essential second messenger c-di-AMP. While regulators like GlmM and CdaR are known, the broader DacA interactome and its functional relevance remain poorly defined...
Environmental fungi modulate the vaginal mycobiome and cervical disease progression in Hispanic women [0.03%]
环境真菌调节西班牙裔女性的阴道真菌群并影响宫颈疾病的发展进展
Filipa Godoy-Vitorino,Daniela Vargas-Robles,Benjamin Bolaños-Rosero et al.
Filipa Godoy-Vitorino et al.
The vaginal mycobiome, though a minor component of the cervicovaginal ecosystem, plays a crucial role in reproductive health and disease. However, its composition and interactions with bacterial communities remain poorly understood, particu...
Expanding vaginal microbiome pangenomes via a custom MIDAS database reveals Lactobacillus crispatus accessory genes associated with cervical dysplasia [0.03%]
通过自定义的MIDAS数据库扩展阴道微生物组泛基因组以揭示与宫颈发育不良相关的乳杆菌辅助基因
Claire A Dubin,Chunyu Zhao,Katherine S Pollard et al.
Claire A Dubin et al.
The vaginal microbiome plays a central role in reproductive health. Vaginal microbiome dysbiosis is associated with many adverse reproductive health outcomes, but most studies have focused on associations at the species level. The potential...
Multi-cohort comparative analysis of salivary microbiotas reveals rural Ethiopians harbor a distinct composition correlated with lower esophageal cancer prevalence [0.03%]
多人群队列比较分析发现埃塞俄比亚农村居民唾液微生物群组成独特且食管癌患病率低
Girma Mulisa,Jingcheng Zhao,Geda Lelissa et al.
Girma Mulisa et al.
Esophageal cancer (EC) results in high mortality due to difficulty in early diagnosis, particularly in low- and middle-income countries, including the African EC belt typified by high prevalence, early onset, and poor prognosis. While the p...
Optimizing methods for virome analysis based on studies of a synthetic viral community [0.03%]
基于合成病毒群研究的病毒组分析方法优化方法
Jiayi Duan,Andrew D Marques,Matthew Hogenauer et al.
Jiayi Duan et al.
Studies of whole viral populations-the "virome"-are yielding exciting new insights into biological systems, but methods are still being optimized. Here, we describe generation and use of a synthetic viral community and its use to evaluate t...
Functional and ecological drivers of bacterial interactions in glacier-fed stream biofilms [0.03%]
功能和生态驱动因素在冰川河流生物膜中细菌相互作用中的影响
Martina Gonzalez Mateu,Hannes Peter,Grégoire Michoud et al.
Martina Gonzalez Mateu et al.
Biofilms are the dominant bacterial lifestyle, consisting of matrix-embedded, spatially structured communities where bacteria closely interact and coordinate their behaviors. Despite their ecological significance, the interplay among bacter...
Mapping the soil microbiome functions shaping wetland methane emissions [0.03%]
绘制影响湿地甲烷排放的土壤微生物组功能地图
Mikayla A Borton,Angela M Oliverio,Adrienne B Narrowe et al.
Mikayla A Borton et al.
Accounting for only 8% of Earth's land cover, freshwater wetlands remain the foremost contributors to global methane emissions. Yet the microorganisms and processes underlying methane emissions from wetland soils remain poorly understood. O...
Chromid-like secondary replicons as predicted key sites of biosynthetic gene clusters in Ktedonobacteria [0.03%]
预测芽单杆菌门生物合成基因簇的重要位置：类似质粒的次级复制子
Shuhei Yabe,Yu Zheng,Shunji Takahashi et al.
Shuhei Yabe et al.
Soils harbor immense biosynthetic gene cluster (BGC) diversity that mediates microbial interactions, yet this potential remains unevenly mapped and poorly characterized across diverse bacterial lineages. Ktedonobacteria (phylum Chloroflexot...