Targeting the gut-ovarian axis: Scutellaria baicalensis improves polycystic ovary syndrome by modulating gut microbiota composition and inhibiting the LPS/TLR4/NF-κB signaling pathway [0.03%]
靶向肠卵巢轴：黄芩改善多囊卵巢综合征的机制或与调节肠道菌群组成及抑制LPS/TLR4/NF-κB信号通路有关
Zhengxiu Pan,Caili Zhang,Qiangqiang Chu et al.
Zhengxiu Pan et al.
Polycystic ovary syndrome (PCOS) is a chronic inflammatory disease caused by a combination of genetic, environmental, and gut microbiota factors. Western medicines can improve ovulation rates, but are linked with reduced pregnancy success a...
Mobile genetic elements shape the evolution and adaptation of the marine Sulfitobacter genus [0.03%]
移动遗传元件塑造了海洋硫杆菌属的进化和适应性
Mustafa Guzel,Frank May,Alison Buchan
Mustafa Guzel
Mobile genetic elements (MGEs) are essential for facilitating horizontal gene transfer and play crucial roles in the evolution and adaptive capabilities of bacterial species. Here, we analyzed closed genomes from the marine Sulfitobacter ge...
A structural backbone with sequestered plasticity organizes the Escherichia coli pangenome [0.03%]
一种具有封存可塑性的结构主干组织埃希氏 coli 全基因组蛋白质编码基因集
Yi-Fei Lu,Guang-Hong Zuo,Xiao-Yang Zhi
Yi-Fei Lu
The exponential growth of microbial genomic data has made computational scalability the primary bottleneck in pangenome analysis because traditional alignment-based methods have quadratic complexity. We developed CVNet, an alignment-free or...
Phase-plastic aggresomes as tunable regulators of bacterial dormancy depth [0.03%]
相塑性聚集体作为可调的细菌休眠调节因子
Jun Yang,Yujia Xian,Chenyi Wang et al.
Jun Yang et al.
Bacterial persistence, a major clinical challenge in chronic and biofilm-associated infections, is driven by a dormant subpopulation capable of surviving antibiotic treatment without acquiring genetic resistance. This review summarizes rece...
Distinguishing Leptothrix and Sphaerotilus genera by an integrated genomic-phenotypic analysis supported by new Leptothrix genomes [0.03%]
基于新的Leptothrix基因组的综合基因组-表型分析区分Leptothrix和Sphaerotilus属细菌
Gracee K Tothero,Jessica L Keffer,David Emerson et al.
Gracee K Tothero et al.
The Sphaerotilus-Leptothrix group of bacteria includes one of the first described microorganisms, Leptothrix ochracea, an uncultured type strain, plus isolates of Leptothrix and Sphaerotilus. This group is unified by the ability to form she...
UV-B-induced DNA repair mechanisms and their effects on mutagenesis and culturability in Escherichia coli [0.03%]
UV-B诱导的DNA修复机制及其对大肠杆菌突变和培养的影响
Sreyashi Ghosh,Jenet Narzary,Mehmet A Orman
Sreyashi Ghosh
Ultraviolet-B (UV-B) radiation, intensified by ozone depletion, induces DNA damage and promotes mutagenesis, shaping evolution. While UV-induced SOS responses are well characterized in bacteria, the cellular consequences of prolonged UV-B e...
Differential co-occurrence analysis: a method to extract ecological modules from clinical microbiome data [0.03%]
差异共发生分析：从临床微生物组数据中提取生态模块的方法
J Iacovacci,N Cannon,J A McCulloch et al.
J Iacovacci et al.
The human microbiota plays a pivotal role in health, with widespread alterations implicated in conditions ranging from inflammatory disorders to cancer. While correlation-based network analyses have illuminated ecological interactions withi...
Reshaping of the fecal proteome and metaproteome in obese patients 2 years after bariatric surgery [0.03%]
肥胖患者接受代谢手术两年后粪便蛋白质组和元蛋白质组的重塑
Alessandro Tanca,Laura De Diego,Maria Antonietta Deledda et al.
Alessandro Tanca et al.
Bariatric surgery provides effective and durable weight loss in patients with severe obesity. Both the surgical procedure and postoperative management, including dietary and behavioral changes, are known to induce long-term alterations in g...
Impact of ceftiofur administration and Escherichia coli inoculation on the calf fecal microbiome [0.03%]
头孢噻呋给药和大肠杆菌接种对犊牛粪便微生物群的影响
Andrew J Sommer,Marta Ferrandis-Vila,Svenja Mamerow et al.
Andrew J Sommer et al.
The cattle gastrointestinal tract harbors a diverse community of microorganisms, including pathogenic and commensal strains of Escherichia coli. Antimicrobial use in cattle can disrupt the gut microbiome, leading to shifts in bacterial dive...
Systemic trade-offs between core and accessory genomes govern stress adaptation in Rhodococcus erythropolis [0.03%]
红球菌核心基因组和辅助基因组之间的系统性权衡决定其应激适应性
Xiaoran Cheng,Huan Liu,Xu Qiu et al.
Xiaoran Cheng et al.
The genus Rhodococcus is a premier biotechnological chassis for organic pollutant bioremediation and natural product biosynthesis, yet the systemic genetic basis of its stress resilience remains poorly defined. Here, we elucidate adaptive s...