MATRIX: rapid quantification of total and active microbial cells with single-cell phenotypes for environmental microbiomes [0.03%]
矩阵：具有单细胞表型的环境微生物组中总活性微生物细胞的快速定量
Milena Gonzalo,Xipeng Liu,Yann S Dufour et al.
Milena Gonzalo et al.
Quantifying the abundance and activity of bacteria within populations and communities is fundamental to systems microbiology and microbiome research. Yet direct microscopic cell counting remains low throughput, labor-intensive, and prone to...
HumanFilt: a multi-reference host depletion pipeline improves Fusobacterium detection accuracy in tumor WGS data sets [0.03%]
HumanFilt：一种多参考宿主去除管道可提高肿瘤WGS数据集中的Fusobacterium检测准确性
Mariia Frolova,Barry Maguire,Heiko Duessmann et al.
Mariia Frolova et al.
The study of tumor-associated microbiomes using whole-genome sequencing (WGS) has attracted considerable attention, but microbial signal detection remains controversial due to host contamination and methodological artifacts. As the necessit...
A metabolic model of the leaf-associated bacterium Paraburkholderia dioscoreae links the ethylene precursor ACC to core carbon pathways [0.03%]
乙烯前体ACC与核心碳代谢路径相连的附生在叶上的根瘤菌Paraburhholderia dioscoreae的代谢模型
Pablo Rolle,Hannah Auricht,Andreea Marcut et al.
Pablo Rolle et al.
Paraburkholderia dioscoreae MSB3T is a novel species with potential agricultural impact, isolated from leaf acumens of the "air potato yam" Dioscorea bulbifera. P. dioscoreae's genome encodes a relevant combination of features mediating a b...
Longitudinal shifts in oral microbiome composition and metabolic pathways associated with preterm birth [0.03%]
与早产相关的口腔微生物组组成和代谢途径的纵向变化
Mousumi Sarkar,Ankita Maddheshiya,Pragya Tailor et al.
Mousumi Sarkar et al.
Oral dysbiosis in pregnant women with oral diseases has been associated with adverse pregnancy outcomes. However, the inter-individual variability in oral microbiome composition of pregnant women without any oral disease, and its role in pr...
Sialidase inhibitor modulates gut microbiota and enhances mucosal protection in the treatment of ulcerative colitis [0.03%]
唾液酸酶抑制剂可调节肠道菌群并增强黏膜保护以治疗溃疡性结肠炎
Yiming Zhao,Lulu Chen,Chunyan Li et al.
Yiming Zhao et al.
Ulcerative colitis (UC) is characterized by mucosal barrier erosion, a process exacerbated by bacterial sialidases. We investigated the therapeutic efficacy of the sialidase inhibitor (SI) in UC. In a pilot randomized clinical trial, SI int...
Effects of gut microbiota on the susceptibility of ischemic stroke in mice [0.03%]
肠道微生物对小鼠缺血性卒中易感性的影响
Guangyan Wu,Huidi Wang,Qianyi Zhou et al.
Guangyan Wu et al.
Ischemic stroke is a highly prevalent disease with limited therapeutic options, and emerging evidence suggests that the gut microbiota influences stroke pathophysiology. However, whether the gut microbiota affects individual susceptibility ...
Gut metaproteomics reveals activated arginine catabolism and impaired arginine biosynthesis in systemic lupus erythematosus [0.03%]
肠道元蛋白质组学揭示了系统性红斑狼疮中活化的精氨酸分解代谢和受损的精氨酸生物合成
Wenjun Xiong,Xuejia Zheng,Ling Yuan et al.
Wenjun Xiong et al.
The resilience of microbial metabolic functions during gut microbiome dysbiosis depends on functional redundancy across taxa. However, this ecological principle remains largely unexplored in human autoimmune diseases such as systemic lupus ...
Higher abundance of Faecalibacterium prausnitzii in the gut microbiome is associated with a lower risk of sepsis development among 6,372 individuals followed for 20 years [0.03%]
肠道微生物组中Faecalibacterium prausnitzii丰度越高，6372名受试者20年内发生败血症风险越低
Hassan Diab,Robert F J Kullberg,Li-Fang Yeo et al.
Hassan Diab et al.
The human gut microbiome has been suggested to be linked with the risk of developing sepsis, a life-threatening medical emergency. However, it remains unclear whether the gut microbiome is an independent predictor of long-term sepsis risk i...
Gabriel Penunuri,Evan Pepper-Tunick,Jakob McBroome et al.
Gabriel Penunuri et al.
Endosymbiotic bacteria such as Wolbachia pose significant challenges to genetic and molecular investigation due to their obligate intracellular lifestyle and complex growth requirements. Current understanding of their protein biology relies...
Bacteriophage replication strategies are associated with organic matter energy content on coral reefs [0.03%]
噬菌体复制策略与珊瑚礁有机物能量含量有关
Natascha S Varona,Lisa Schellenberg,Will Barnes et al.
Natascha S Varona et al.
Bacteriophages, viruses that infect bacteria, play a crucial role in carbon cycling within marine environments. In coral reefs, dissolved organic matter (DOM) released by benthic primary producers such as algae fuels heterotrophic microbial...