Pandoomain, a scalable pipeline for genomic and protein domain context analysis, reveals widespread PT-TG domain architectural diversity and novel polymorphic toxins [0.03%]
一种可扩展的基因组和蛋白质结构域背景分析管道Pandoomain揭示了广泛存在的PT-TG结构域构建多样性以及新型多态毒素
Emanuel Becerra Soto,Adam J Oliver,Marcos H de Moraes
Emanuel Becerra Soto
The rapid expansion of bacterial genome databases presents significant opportunities for functional discovery, as a large fraction of genes and protein domains remain uncharacterized. Analyzing genomic context and domain architecture is a p...
Allium mongolicum Regel flavonoids promote intestinal health in goats by regulating bile acid metabolism and gut microbiota [0.03%]
蒙古葱花青素通过调节胆汁酸代谢和肠道微生物群促进山羊肠道健康
Ruixin Yang,Aihuan Yu,Yaodi Xie et al.
Ruixin Yang et al.
Bile acids (BAs) are processed and modified by intestinal microorganisms into various secondary BAs, which play a crucial role in maintaining intestinal homeostasis. Recent studies indicate that flavonoids influence the gut microbiota-BAs a...
The associations of human genetic variations with airway microbiome, environmental exposures, and respiratory health [0.03%]
人类遗传变异与呼吸道微生物组、环境暴露和呼吸健康之间的关联
Shifen Xu,Lei Yang,Jingyuan Gao et al.
Shifen Xu et al.
The intricate interactions between environmental exposures, the respiratory microbiome, and host genetic variations remain inadequately understood in the context of respiratory health. This study utilized sputum metagenomic data from 1,651 ...
misosoup: a metabolic modeling tool for identifying minimal microbial communities, facilitates the exploration of microbial ecology and biotechnological applications [0.03%]
MisoSoup：一种用于识别最小微生物群的代谢模型工具，有助于探索微生物生态学和生物技术应用
Nicolas Ochsner,Magdalena San Román,Adrián Jiménez-Fernández et al.
Nicolas Ochsner et al.
Microbial survival and function often depend on metabolic interactions within communities. Therefore, a central question in disentangling microbial organization is determining which minimal groups of strains are able to thrive in a given me...
Participant engagement and feedback in microbiome projects: a case of AWI-Gen 2 [0.03%]
宏基因组研究中的参与者互动和反馈：AWI-Gen 2案例研究
Claudine K Nkera-Gutabara,Luicer A Ingasia Olubayo,Ovokeraye O Oduaran et al.
Claudine K Nkera-Gutabara et al.
Returning individualized microbiome results in ways that are ethical, comprehensible, and useful remains under-explored in African settings. We nested a multi-site, mixed-methods study within the AWI-Gen Wave 2 gut microbiome sub-study of 1...
Microbiota assembly in Zostera marina during early host development across controlled growth experiments [0.03%]
随着宿主早期发育在海洋关键物种Zostera marina内进行受控培养实验的微生物群落构建过程研究
Gina Chaput,Emma A Deen,Eric Q Pham et al.
Gina Chaput et al.
Seagrass restoration practices are evolving to leverage microbiome applications, similar to agricultural systems that have demonstrated how targeted microbial communities enhance crop resilience in challenging environments. While adult seag...
Population-level genome sequencing reveals distinct Mycobacterium tuberculosis intrahost mutational trajectories in simian immunodeficiency virus-coinfected and antiretroviral treated non-human primates [0.03%]
灵长类免疫缺陷病毒共感染和接受抗逆转录病毒治疗的非人灵长类动物中，结核分枝杆菌单克隆扩增及突变特征研究（英语）
Michael C Chao,Michael R Chase,Shoko Wakabayashi et al.
Michael C Chao et al.
Whole-genome sequencing of Mycobacterium tuberculosis (Mtb) populations from clinical samples has increasingly identified genes undergoing selection within and between hosts that drive differential infection and treatment outcomes. However,...
A fungal exudate-inspired substrate mixture elicits an emergent growth phenotype and metabolic responses in Pseudomonas putida [0.03%]
一种由真菌渗出物激发的载体混合物诱导Pseudomonas putida产生生长表型和代谢响应
Natalie Sadler,Elise Van Fossen,Grace Black et al.
Natalie Sadler et al.
Microbes in natural environments often encounter diverse mixtures of organic compounds, yet how mixed substrate environments and their molecular composition shape microbial phenotypes remains understudied. Here, we examined how a defined fu...
Experimental evolution reveals genetic and transcriptomic mechanisms underlying benzalkonium chloride tolerance and fluoroquinolone cross-resistance in Listeria monocytogenes [0.03%]
实验进化揭示了单增李斯特菌苯扎氯铵耐受和氟喹诺酮类交叉耐药的遗传及转录组机制
Tyler D Bechtel,Julia Hershelman,Adenike Adeyanju et al.
Tyler D Bechtel et al.
Preventing Listeria monocytogenes persistence in food processing environments is challenged by tolerance to quaternary ammonium compound sanitizers such as benzalkonium chloride (BAC). To define the genetic and molecular routes to BAC toler...
Integrative multicohort analysis reveals consistent sex differences in gut microbiota of multiple sclerosis patients [0.03%]
整合多队列分析揭示了多发性硬化症患者肠道菌群的性别差异
Irene Soler-Sáez,Cristina Galiana-Roselló,Rubén Grillo-Risco et al.
Irene Soler-Sáez et al.
Biological sex is a key determinant in the onset and progression of multiple diseases. In multiple sclerosis (MS), females exhibit higher disease prevalence, earlier onset, and more pronounced inflammatory activity, whereas males tend to ex...