CAZyme fold architecture is conserved between disparate environments despite extreme sequence divergence [0.03%]
极具序列差异性的酶的折叠结构在不同环境中具有保守性
Oliyad Jeilu,Addis Simachew,Erica M Hartmann et al.
Oliyad Jeilu et al.
Microbial carbohydrate-active enzymes (CAZymes) underpin carbon cycling across Earth's ecosystems; however, how contrasting environments shape CAZyme diversity and structural conservation remains poorly understood. Here, we applied shotgun ...
Metabolic robustness is an emergent property of hierarchical network organization in yeast [0.03%]
hierarchial网络组织在酵母代谢鲁棒性的一个属性
Mohammad Tauqeer Alam
Mohammad Tauqeer Alam
Biological systems exhibit intrinsic robustness, allowing cells to sustain growth despite diverse perturbations. We quantified the inherent robustness of the Saccharomyces cerevisiae genome-scale metabolic network by globally perturbing met...
Turicibacter sanguinis is a candidate gut microbial pathobiont that promotes metabolic dysfunction-associated steatohepatitis [0.03%]
牙龈密螺旋体是一种肠道微生物病原体候选菌，可促进与代谢紊乱相关的肝炎病情发展
Jing Guo,Zhong-Wen Xiang,Fang-Fang Hu et al.
Jing Guo et al.
Emerging evidence points to the gut microbiota's involvement in metabolic dysfunction-associated steatohepatitis (MASH), yet the specific causative microbes remain largely unidentified. This study aimed to identify and functionally characte...
Salinity-driven adaptations and evolution of DNA viruses in estuarine-coastal ecosystems [0.03%]
盐驱动的适应和进化： estuary-沿岸生态系统中DNA病毒的演变
Wenqing Shi,Lu Liu,Lilin Wu et al.
Wenqing Shi et al.
Salinity gradients drive microbial diversity and evolution in estuarine-coastal ecosystems, yet viral adaptation remains less well understood. We used metagenomics to study viral adaptation and functions in three representative estuarine-co...
Exploring bet-hedging in Salmonella enterica serovar Typhimurium with a dual reporter strain [0.03%]
采用双报告菌株在鼠伤寒沙门氏菌中探索贝叶斯决策理论中的下注策略现象
Michelle I Gerber,Murugesan Sivaranjani,Kyle Vincent et al.
Michelle I Gerber et al.
Non-typhoidal Salmonella are a leading cause of foodborne illness. These pathogens cycle between infecting hosts and persisting in the environment as biofilms. Unfortunately, this transition stage is not well understood. In non-typhoidal Sa...
Canonical transcription termination mechanisms explain a minority of operons in cyanobacteria [0.03%]
canonical transcription终止机制只能解释极少数的 Cyanobacteria 操纵子
Jennifer A Cascino,K Julia Dierksheide,Rishi K Vishwakarma et al.
Jennifer A Cascino et al.
Cyanobacteria are abundant phototrophs and hold potential as a carbon-negative platform for bioengineering applications. However, these efforts have been hampered by limited mechanistic understanding of their gene expression, including tran...
The Pel polysaccharide modulates interspecies interactions between Pseudomonas aeruginosa and Mycobacterium abscessus [0.03%]
Pel多糖调节绿脓杆菌与嗜黏液芽胞杆菌种间相互作用
Melissa S McDaniel,Sara E Edmonds,Evani N Patel et al.
Melissa S McDaniel et al.
Modulator therapies have improved outcomes for people with cystic fibrosis (pwCF), and currently, more than 50% of pwCF are over the age of 18. This has resulted in an increased prevalence of atypical pathogens, including non-tuberculous my...
Detection and characterization of protein methylation in bacteriophages and their host, Cellulophaga baltica, during infection [0.03%]
噬菌体及其宿主Cellulophaga baltica在感染过程中蛋白质甲基化的检测与表征
Andrew J Stai,Cristina Howard-Varona,Marion Urvoy et al.
Andrew J Stai et al.
Bacteria and their viruses (bacteriophages or phages) are in a dynamic "arms race" that balances predation and resistance, using various strategies to achieve dominance. To better understand these strategies, we infected the marine model ba...
Dry versus wet dormancy: suspended lives of Bacillus subtilis versus Saccharomyces cerevisiae spores [0.03%]
干型与湿型休眠：枯草芽孢杆菌和酿酒酵母孢子的休眠形式比较
Hyun Youk
Hyun Youk
Dormant microbial spores provide one of the clearest and most extreme examples of how cells can pause life for extended periods and then reliably restart it. Although bacterial and fungal spores are often grouped under "dormancy," the physi...
Host norepinephrine biases codon-dependent virulence translation in EHEC [0.03%]
宿主去甲肾上腺素使EHEC中的密码子依赖性致病性通读向有利方向倾斜
Zeynep Baharoglu
Zeynep Baharoglu
Bacterial pathogens sense host-derived signals to control virulence, yet how these cues shape translation remains unclear. McShane et al. show that the host hormone norepinephrine rewires the tRNA epitranscriptome of enterohemorrhagic Esche...