Profiling the aromatic amino acid metabolome in the human gut microbiota reveals Clostridioides difficile-specific N-acyl amino acids [0.03%]
人类肠道微生物组中芳香族氨基酸代谢组的分析鉴定出与艰难梭菌相关的N-酰化氨基酸
David Chun-Cheng Hsieh,Linhai Jiang,Mengzhao Xue et al.
David Chun-Cheng Hsieh et al.
Owing to its compositional and chemical complexity, much of the gut microbiota metabolome remains poorly characterized. Aromatic amino acids (AAAs) have a history of being privileged substrates for the biosynthesis of diverse bioactive meta...
Profiling the aromatic amino acid metabolome in the human gut microbiota reveals Clostridioides difficile-specific N-acyl amino acids [0.03%]
人类肠道微生物群中芳香族氨基酸代谢组的剖析发现了与艰难梭菌特异性的N-酰基氨基酸
David Chun-Cheng Hsieh,Linhai Jiang,Mengzhao Xue et al.
David Chun-Cheng Hsieh et al.
Owing to its compositional and chemical complexity, much of the gut microbiota metabolome remains poorly characterized. Aromatic amino acids (AAAs) have a history of being privileged substrates for the biosynthesis of diverse bioactive meta...
Regulatory divergence and functional diversification of a c-di-GMP-controlled sigma factor in Actinomycetota [0.03%]
.Actinomycetota中由c-di-GMP调控的σ因子的监管分歧和功能分化
Joee D Denis,Govind Chandra,Justine J Choi et al.
Joee D Denis et al.
Members of the σ28 family of alternative σ factors typically regulate genes involved in flagellar biosynthesis. However, the only member of the σ28 family present in the actinobacterial genus Streptomyces, WhiG, controls the differentiat...
Metabolic rewiring of bacterial subpopulations governs polymyxin responses in Acinetobacter baumannii [0.03%]
baumannii中细菌亚群的代谢重构治理多粘菌素反应
Mei-Ling Han,Zhi Ying Kho,Xingjian Wang et al.
Mei-Ling Han et al.
Polymyxins are often last-resort antibiotics against high-priority Gram-negative pathogens, particularly Acinetobacter baumannii. However, most mechanistic studies to date have overlooked the heterogeneity within bacterial populations durin...
The quantitative amino acid economy of yeast reveals public versus private goods and guides syntrophic community design [0.03%]
酵母定量氨基酸经济学揭示了公共资源与私人资源并指导共生社区设计
Shabbir Ahmad,Ganesh Muthu,Sunil Laxman
Shabbir Ahmad
The biosynthetic capacity of a cell governs the production and exchange of amino acids. Given the distinct metabolic origins and intracellular requirements for amino acids, it is essential to establish quantitative amounts of internal amino...
Differential proteomics of bacteria grown in vitro and in planta reveals functions used during growth on maize roots [0.03%]
细菌体外和体内生长的差异蛋白质组学揭示了在玉米根系上生长时的作用机制
Anna-Katharina Garrell,John Cheadle,Nathan Crook et al.
Anna-Katharina Garrell et al.
Microbes are ubiquitous in the rhizosphere and play crucial roles in plant health; however, the metabolisms and physiologies of individual species in planta remain poorly understood. In this study, we examined microbial gene expression in r...
Erratum for Firrman et al., "An in vitro model of the small intestinal microbiota provides key insights into interindividual variability in structure and function" [0.03%]
Firrman等人的“小肠微生物群的体外模型提供了结构和功能个体间差异的关键见解”的勘误表
Jenni Firrman,LinShu Liu,Karley Mahalak et al.
Jenni Firrman et al.
Published Erratum
mSystems. 2026 Aug 5:e0099926. DOI:10.1128/msystems.00999-26 2026
The FERM guild: a differentially correlated microbial module drives hypertension via metabolic flux perturbations [0.03%]
FERM菌属：一个差异相关的微生物模块通过代谢流扰动驱动高血压
Wenkai Lai,Yuchen Zhang,Shaoping Huang et al.
Wenkai Lai et al.
Hypertension is a major risk factor for cardiovascular diseases, with changes in gut microbiota composition and function being closely associated with its onset and progression. However, the high inter-individual variability in gut microbio...
Establishment of an in vitro aerobic bacterial community as a model of the human lung microbiome [0.03%]
体外需氧细菌菌群的建立作为人体肺微生物组模型
Maria Kulosa,Matheus Regis Belisário-Ferrari,Florian Semmler et al.
Maria Kulosa et al.
The human lung microbiome is increasingly recognized as a key player in drug metabolism, yet it remains largely understudied. To replicate this complex physiological environment in a controlled setting, we developed a simplified artificial ...
High-resolution taxonomic profiling and metatranscriptomics identify microbial, biochemical, host, and ecological factors in peri-implant disease [0.03%]
高分辨率的分类分析和元转录组学确定了种植体周围病的微生物、生化、宿主及生态因素
Szymon P Szafrański,Amruta A Joshi,Matthias Steglich et al.
Szymon P Szafrański et al.
Biofilm-associated diseases like peri-implant mucositis (PIM) and peri-implantitis (PI) are significant clinical challenges affecting millions of dental implant patients globally. Although studies have described the role of microbial, host,...