No Evidence for Endocannabinoid-Induced G Protein Subtype Selectivity at Human and Rodent Cannabinoid CB1 Receptors [0.03%]
人和啮齿动物 cannabinoid cb1 体不存在内源大麻素诱导的 g 蛋白亚型选择性证据
Xiaoxi Zheng,Beth Ehrlich,David Finlay et al.
Xiaoxi Zheng et al.
Introduction: The endocannabinoid system (ECS) is a widespread neurotransmitter system. A key characteristic of the ECS is that there are multiple endogenous ligands (endocannabinoids). Of these, the most extensively studied are arachidonoy...
Repeated Administration of a Full-Spectrum Cannabidiol Product, Not a Cannabidiol Isolate, Reverses the Lipopolysaccharide-Induced Depressive-Like Behavior and Hypolocomotion in a Rat Model of Low-Grade Subchronic Inflammation [0.03%]
重复给予全光谱大麻二酚产品，而不是大麻二酚单体，可逆转内毒素诱导的抑郁样行为和低级亚慢性炎症模型小鼠的低运动行为
Linério Ribeiro de Novais Júnior,Tiago Vicente da Silva,Larissa Mendes da Silva et al.
Linério Ribeiro de Novais Júnior et al.
Background: Mounting evidence suggests that the phytocannabinoid cannabidiol (CBD) holds promise as an antidepressant agent in conditions underlined by inflammation. Full-spectrum CBD extracts might provide greater behavioral efficacy than ...
Effect of Cannabistilbene I in Attenuating Angiotensin II-Induced Cardiac Hypertrophy: Insights into Cytochrome P450s and Arachidonic Acid Metabolites Modulation [0.03%]
大麻色满醇I对血管紧张素Ⅱ诱导的心肌肥厚的改善作用及其对细胞色素P450和花生四烯酸代谢物的影响研究
Ahmad H Alammari,Fadumo Ahmed Isse,Conor O&#x;Croinin et al.
Ahmad H Alammari et al.
Introduction: This research investigated the impact of Cannabistilbene I on Angiotensin II (Ang II)-induced cardiac hypertrophy and its potential role in cytochrome P450 (CYP) enzymes and arachidonic acid (AA) metabolic pathways. Cardiac hy...
A Statewide Examination of Medical Cannabis Purchasing Patterns in Arkansas Over the Three Years Immediately Following Legalization [0.03%]
阿肯色州医用大麻购买模式的全州范围调查——法律实施三年后的结果
Bradley C Martin,Joseph W Thompson,Anthony Goudie et al.
Bradley C Martin et al.
Introduction: The use of medical cannabis (MC) to treat a host of conditions has expanded considerably in the United States; however, precise quantitative assessments of purchasing characteristics are unknown. This study sought to character...
Association of Serum Endocannabinoid Levels with Pancreatitis and Pancreatitis-Related Pain [0.03%]
内源性大麻素水平与胰腺炎及其相关疼痛的关系
Marc T Goodman,Christina Lombardi,Alexa Torrens et al.
Marc T Goodman et al.
Background and Aims: This investigation examined the association of pancreatitis and pancreatitis-related pain with serum levels of two endocannabinoid molecules such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG) and two paracannabi...
Endometrial Cell-Type Specific Regulation of the Endocannabinoids System and the Impact of Menstrual Cycle and Endometriosis [0.03%]
子宫内膜细胞类型特异性内源大麻素系统的调节以及月经周期和子宫内膜异位症的影响
Keisuke Tanaka,Sugarniya Subramaniam,Sharat Atluri et al.
Keisuke Tanaka et al.
Introduction: Anandamide (AEA) and 2-arachidonoylglycerol are endogenous agonists of the cannabinoid receptors and regulate and control many cellular functions. Their activities are governed by enzymes and proteins that regulate their synth...
Associations of Cannabis Use, Metabolic Dysfunction-Associated Steatotic Liver Disease, and Liver Fibrosis in U.S. Adults [0.03%]
大麻使用与美国成年人代谢功能紊乱相关脂肪肝病和肝纤维化的关联研究
Yu Wu,Fei Fang,Xingliang Fan et al.
Yu Wu et al.
Introduction: Following the introduction of metabolic dysfunction-associated steatotic liver disease (MASLD) as a replacement term for nonalcoholic fatty liver disease, the relationship between MASLD and cannabis use has yet to be establish...
Neonatal Cannabidiol Exposure Impairs Spatial Memory and Disrupts Neuronal Dendritic Morphology in Young Adult Rats [0.03%]
新生大鼠接触大麻二酚会损害年长幼鼠的空间记忆并扰乱神经元树突形态
Meetu Wadhwa,Gregory A Chinn,Jennifer M Sasaki Russell et al.
Meetu Wadhwa et al.
Introduction: Early life is a sensitive period for brain development. Perinatal exposure to cannabis is increasingly linked to disruption of neurodevelopment; however, research on the effects of cannabidiol (CBD) on the developing brain is ...
Chapman Wei,Nawal Mustafa,Radu Grovu et al.
Chapman Wei et al.
Background: Cannabis use is becoming increasingly prevalent worldwide, yet the full spectrum of its effects largely remain unknown. Although cannabis have immunomodulatory properties, there remains a significant gap in our understanding of ...
Chronic Cannabidiol Administration Mitigates Excessive Daytime Sleepiness and Fatigue in Patients with Primary Hypertension: Insights from a Randomized Crossover Trial [0.03%]
大麻二酚缓释制剂对原发性高血压患者日间过度嗜睡和疲劳的改善作用：一项随机交叉试验的新发现
Goran Dujic,Marko Kumric,Josip Vrdoljak et al.
Goran Dujic et al.
Background: The chronic effects of cannabidiol (CBD) supplementation on factors that could impact the quality of life (anxiety, sleeping quality, memory, etc.) are poorly explored. Hence, the aim of this study was to establish whether chron...