The Pharmacokinetics and Pharmacodynamics of a Hemp-Derived "Full-Spectrum" Oral Cannabinoid Product with a 1:1 Ratio of Cannabidiol to Cannabidiolic Acid and Delta-9-Tetrahydrocannabinol to Delta-9-Tetrahydrocannabinolic Acid: A Double-Blind, Placebo-Controlled, Within-Subjects Human Laboratory Study [0.03%]
大麻衍生的“全光谱”口服大麻素产品的药代动力学和药效学，该产品含有1:1比例的大麻二酚与大麻二酚酸以及Delta-9四氢大麻酚与Delta-9四氢大麻酚酸：一项双盲、安慰剂对照、单因素人体实验室研究
Harrison J Elder,C Austin Zamarripa,McKenna Klausner et al.
Harrison J Elder et al.
Aim: To examine the acute pharmacokinetics (PK) and pharmacodynamics (PD) of a patented oral cannabinoid product containing a botanical hemp-derived "full-spectrum" extract with an approximate 1:1 ratio of cannabidiol (CBD) to cannabidiolic...
Chronic Disease Symptoms Self-Managed by Cannabis During the COVID-19 Pandemic: Results from the COVID-19 Cannabis Health Study [0.03%]
COVID-19大流行期间用大麻自我管理慢性病症状的结果：来自COVID-19大麻健康研究的数据
Nicole O&#x;Dell,Amrit Baral,Marvin Reid et al.
Nicole O&#x;Dell et al.
Background: The COVID-19 pandemic has impacted billions of people worldwide, particularly those with chronic health conditions, and has been associated with increases in substance use, including cannabis. The purpose of this study was to es...
Solange de Souza Stork,Khiany Mathias,David Dos Santos et al.
Solange de Souza Stork et al.
Introduction: Cannabinoids are increasingly being explored as a potential treatment for neurodegenerative diseases. This article aims to provide a narrative review of available data on the treatment of neurological disorders with cannabis c...
Combined Endocannabinoid and Cyclooxygenase Inhibition Additively Attenuates Post-Surgical Pain [0.03%]
联合内源大麻素和环氧化酶抑制剂治疗可协同缓解术后疼痛
Carl E B Rodriguez,S Olivia Vanegas,A Matthew Reck et al.
Carl E B Rodriguez et al.
Introduction: Post-surgical pain arises following a clinical operation, often persisting throughout recovery. While current treatments reduce pain, repeated use increases the probability of adverse events. monoacylglycerol lipase (MAGL) inh...
Circulating Endocannabinoids Are Associated with Mental Alertness During Ultra-Endurance Exercise [0.03%]
循环内源大麻素与超长耐力运动中的精神警觉性有关
Sebastiaan Dalle,Chiel Poffé,Wout Lauriks et al.
Sebastiaan Dalle et al.
Introduction: Ultra-endurance exercise events result in central fatigue, impacting on mental alertness and decision making. Endocannabinoids are typically elevated during endurance exercise and have been implicated in central processes such...
A Preliminary Pharmacokinetic Comparison of Δ-9 Tetrahydrocannabinol and Cannabidiol Extract Versus Oromucosal Spray in Healthy Men and Women [0.03%]
口服提取 cannabidiol 和舌下含服喷雾剂在健康男性和女性中的药代动力学初步比较研究：与 THC 相关的发现
Caroline A Arout,Hannah M Harris,Noah M Wilson et al.
Caroline A Arout et al.
Aim: Few studies have directly compared the bioavailability of different cannabinoid formulations. Our goal was to assess the pharmacokinetic parameters and relative bioavailability of two Δ9-tetrahydrocannabinol:cannabidiol (THC:CBD) form...
How Veterans with Chronic Pain Approach Using Cannabis for Symptom Management: Results from a Qualitative Interpretive Description Study [0.03%]
慢性疼痛退伍军人如何利用大麻进行症状管理：定性解释性描述研究的结果
Rachel S Bergmans,Christine Yu,Bhaavna Yalavarthi et al.
Rachel S Bergmans et al.
Introduction: Veterans use cannabis as a chronic pain treatment due to a combination of the easing of restrictions and dissatisfaction with care standards. The segregation of medical cannabis from conventional health systems may translate t...
Drug Interactions in People on Cannabidiol: Is There Cause for Concern? [0.03%]
cannabidiol治疗患者的药物相互作用值得关注吗？
Georgia Downs,Ristan Greer,Geraldine Moses et al.
Georgia Downs et al.
Introduction: Cannabidiol (CBD) exhibits multiple therapeutic properties, but its use in advanced cancer patients raises concerns about potential drug-drug interactions (DDIs) due to polypharmacy. This study aims to look for evidence of DDI...