A Phase 2 Randomized Controlled Trial of the Efficacy and Safety of Cannabidivarin as Add-on Therapy in Participants with Inadequately Controlled Focal Seizures [0.03%]
cannabidivarin治疗控制不佳的局灶性癫痫发作患者的疗效和安全性的2期随机对照试验
Martin J Brodie,Piotr Czapinski,Ladislav Pazdera et al.
Martin J Brodie et al.
Objective: We assessed the efficacy, safety, and tolerability of cannabidivarin (CBDV) as add-on therapy in adults with inadequately controlled focal seizures. Materials and Methods: One hundred and sixty-two participants (CBDV n=81; placeb...
Trends in Prevalence and Outcomes of Cannabis Use Among Chronic Obstructive Pulmonary Disease Hospitalizations: A Nationwide Population-Based Study 2005-2014 [0.03%]
基于全国人口的2005-2014年慢性阻塞性肺疾病住院患者的使用趋势及预后研究
Kulothungan Gunasekaran,Dinesh C Voruganti,Mandeep Singh Rahi et al.
Kulothungan Gunasekaran et al.
Background: Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of mortality in the United States. Due to the ongoing legalization of cannabis, its acceptance, availability, and use in the in-patient population are on t...
Regarding the Mechanisms of Promiscuous Cannabinoid Pharmacology: An Elephant Has Entered the Room [0.03%]
论促性 cannabionoid 药理作用的机制：大象已进入房间
Peter S Cogan
Peter S Cogan
Decades of research have discovered a broad variety of interesting in vitro activities resulting from cannabinoid exposure. Recent investigations of cannabidiol, however, present a potential explanation for these findings, which relies on t...
Effects of Cannabidiol Chewing Gum on Perceived Pain and Well-Being of Irritable Bowel Syndrome Patients: A Placebo-Controlled Crossover Exploratory Intervention Study with Symptom-Driven Dosing [0.03%]
大麻二酚口香糖对肠易激综合症患者感知到的疼痛和幸福感的影响：一项以症状驱动给药的安慰剂对照交叉探索性干预研究
Anne-Claire B van Orten-Luiten,Nicole M de Roos,Soumia Majait et al.
Anne-Claire B van Orten-Luiten et al.
Background: Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders. Its pathophysiology is diverse and variable, involving disturbed gut-brain interactions, altered motility and secretion, visceral hypersensitiv...
Randomized Controlled Trial
Cannabis and cannabinoid research. 2022 Aug;7(4):436-444. DOI:10.1089/can.2020.0087 2022
Modulation of Recombinant Human T-Type Calcium Channels by Δ9-Tetrahydrocannabinolic Acid In Vitro [0.03%]
Δ9-四氢大麻酸对体外重组人T型电压门控钙离子通道的调节作用
Somayeh Mirlohi,Chris Bladen,Marina Santiago et al.
Somayeh Mirlohi et al.
Introduction: Low voltage-activated T-type calcium channels (T-type ICa), CaV3.1, CaV3.2, and CaV3.3, are opened by small depolarizations from the resting membrane potential in many cells and have been associated with neurological disorders...
Daniel J Kruger,Natalie J Korach,Jessica S Kruger
Daniel J Kruger
Introduction: As more states allow for medical and nonregistered adult cannabis (i.e., marijuana) use, ensuring proper utilization should be a priority. Standardized labeling for foods and pharmaceutical drugs promotes consumer safety. This...
The Cannabinoid Receptor Agonist, WIN-55212-2, Suppresses the Activation of Proinflammatory Genes Induced by Interleukin 1 Beta in Human Astrocytes [0.03%]
cannabinoid受体激动剂WIN-55212-2抑制白介素1β诱导的小胶质细胞源性炎症因子的表达
Jerel Adam Fields,Mary K Swinton,Patricia Montilla-Perez et al.
Jerel Adam Fields et al.
Background: Alterations of astrocyte function play a crucial role in neuroinflammatory diseases due to either the loss of their neuroprotective role or the gain of their toxic inflammatory properties. Accumulating evidence highlights that c...
Legalizing Medical Cannabis in Lebanon: the Complex Interface Between Medicine, Law, Ethics, and Economics [0.03%]
黎巴嫩医疗大麻合法化：医学、法律、伦理和经济的复杂交织关系
Joseph El-Khoury,Rami Bou Khalil,Anthony Nemer et al.
Joseph El-Khoury et al.
In April 2020, after decades of discussions and controversy, the Lebanese parliament voted a law legalizing the cultivation, production, and sale of cannabis for medicinal purposes. Although the law leaves several unanswered questions and a...
Daniel J Corsi,Malia S Q Murphy,Jocelynn Cook
Daniel J Corsi
Introduction: Cannabis is commonly used for its medicinal and therapeutic benefits and is also widely used as a recreational drug. Cannabis use has been increasing in Canada, including among Canadian women of reproductive age. Post-legaliza...
Cannabidiol Interferes with Establishment of Δ9-Tetrahydrocannabinol-Induced Nausea Through a 5-HT1A Mechanism [0.03%]
cannabidiol通过5-HT1A机制干扰Δ9-tetrahydrocannabinol诱导的恶心的建立
Marieka V DeVuono,Olivia La Caprara,Gavin N Petrie et al.
Marieka V DeVuono et al.
Introduction: Cannabinoid hyperemesis syndrome (CHS) is characterized by intense nausea and vomiting brought on by the use of high-dose Δ9-tetrahydrocannabinol (THC), the main psychotropic compound in cannabis. Cannabidiol (CBD), a nonpsyc...