Evaluating the Antinociceptive Efficacy of Cannabidiol Alone or in Combination with Morphine Using the Formalin Test in Male and Female Mice [0.03%]
使用甲醛测试评估大麻二酚单独或与吗啡联用在雄性和雌性小鼠中的镇痛疗效
Diana E Sepulveda,Daniel P Morris,Wesley M Raup-Konsavage et al.
Diana E Sepulveda et al.
Introduction: Phytocannabinoids have emerged as a potential alternative treatment option for individuals experiencing persistent pain. However, evidence-based research regarding their clinical utility in both males and females remains incom...
The Cannabis-Dependent Relationship Between Methadone Treatment Dose and Illicit Opioid Use in a Community-Based Cohort of People Who Use Drugs [0.03%]
药物使用人群中美沙酮治疗剂量与非法阿片类药物使用之间的依赖关系研究
Stephanie Lake,Thomas Kerr,Jane Buxton et al.
Stephanie Lake et al.
Background: Methadone maintenance treatment (MMT) is an effective treatment for opioid use disorder. However, subtherapeutic dosing may lead to continued opioid use by failing to suppress opioid withdrawal and craving. Preclinical and pilot...
Consumer Experiences with Delta-8-THC: Medical Use, Pharmaceutical Substitution, and Comparisons with Delta-9-THC [0.03%]
消费者使用Delta-8-THC的经验：医疗用途，药品替代以及与Delta-9-THC的比较
Daniel J Kruger,Jessica S Kruger
Daniel J Kruger
Introduction: Cannabis products containing delta-8-THC became widely available in most of the United States in late 2020 and rapidly became a significant source of revenue for hemp processing companies, especially in states where use of del...
Objective Identification of Cannabis Use Levels in Clinical Populations Is Critical for Detecting Pharmacological Outcomes [0.03%]
临床人群中大麻使用水平的目标识别对于检测药理结果至关重要
Weize Huang,Lindsay C Czuba,Jennifer A Manuzak et al.
Weize Huang et al.
Introduction: Cannabis is widely used for recreational and medical purposes, but its therapeutic efficacy remains unresolved for many applications as data from retrospective studies show dramatic discrepancy. We hypothesized that false self...
Perceived Efficacy, Reduced Prescription Drug Use, and Minimal Side Effects of Cannabis in Patients with Chronic Orthopedic Pain [0.03%]
慢性骨科疼痛患者中大麻的感知疗效，降低处方药物使用以及最小副作用
Ari Greis,Eric Larsen,Conan Liu et al.
Ari Greis et al.
Introduction: Although cannabis is widely used for the treatment of chronic pain, most research relies on patient self-report and few studies have objectively quantified its efficacy and side effects. Extant inventories for measuring cannab...
Observational Study
Cannabis and cannabinoid research. 2022 Dec;7(6):865-875. DOI:10.1089/can.2021.0088 2022
Cannabidiol Does Not Impact Acute Anabolic or Inflammatory Signaling in Skeletal Muscle In Vitro [0.03%]
大麻二酚对骨骼肌的急性合成或炎症信号没有影响
Henning T Langer,Alec Avey,Keith Baar
Henning T Langer
Background: Cannabidiol (CBD) is becoming increasingly popular for the treatment of clinical conditions including as an aid for muscle recovery. Previous work demonstrated that CBD exhibited mild effects on skeletal muscle, with a tendency ...
Relationship Between Recreational Cannabis Use and Helicobacter pylori Infection [0.03%]
娱乐用大麻的使用与幽门螺杆菌感染的关系
Adeyinka Charles Adejumo,Patrick Labonte,Terence Ndonyi Bukong
Adeyinka Charles Adejumo
Background: Cannabis plant extracts suppress gastric acid secretion and inflammation, and promote gastroduodenal ulcer healing, all of which are triggered by Helicobacter Pylori infection (HPI). Here, we evaluate the association between can...
Administration of Δ9-Tetrahydrocannabinol Following Controlled Cortical Impact Restores Hippocampal-Dependent Working Memory and Locomotor Function [0.03%]
控制性皮质撞击后应用Δ9-四氢大麻酚可恢复海马依赖的工作记忆和运动功能
Shijie Song,Xiaoyuan Kong,Bangmei Wang et al.
Shijie Song et al.
Hypothesis: Administration of the phytocannabinoid Δ9-tetrahydrocannabinol (Δ9-THC) will enhance brain repair and improve short-term spatial working memory in mice following controlled cortical impact (CCI) by upregulating granulocyte col...
Letter to the Editor: Cannabis as a Solution to the Opioid Crisis: Is the Cart Before the Horse Again? [0.03%]
写给编辑的一封信：大麻作为解决阿片类危机的方法：是否又本末倒置了？
Joao P De Aquino,Anees Bahji,Deepak C D&#x;Souza
Joao P De Aquino
ABHD6 Controls Amphetamine-Stimulated Hyperlocomotion: Involvement of CB1 Receptors [0.03%]
ABHD6调控安非他命刺激的超动：CB1受体的作用
Liting Deng,Katie Viray,Simar Singh et al.
Liting Deng et al.
Introduction: Activation of cannabinoid 1 receptors (CB1Rs) by endocannabinoids (eCBs) is controlled by both eCB production and eCB inactivation. Accordingly, inhibition of eCB hydrolyzing enzymes, monoacylglycerol lipase (MAGL) and α/β-h...