Combination of Cannabidiol and Low-Dose Buprenorphine Suggests Synergistic Analgesia and Attenuates Buprenorphine-Induced Respiratory Depression [0.03%]
大麻二酚与低剂量布托品联合使用可产生协同镇痛作用并减轻布托品引起的呼吸抑制反应
Marisa S Briones,Dustin Z DeYoung,Keith G Heinzerling
Marisa S Briones
Introduction: As opioid-related drug overdoses remain a public health crisis, there is a critical need for innovative approaches to developing safer analgesics with improved safety profiles. BDH-001 is a fixed-dose combination of low-dose b...
Cannabidiol Gummy Products: LC-MS/MS Assessment of Cannabinoid Concentrations [0.03%]
CBD凝胶糖果产品的LC-MS/MS法测定 cannabinoid含量
Erin D Johnson,Michael W Kilgore,Maribeth Stafford et al.
Erin D Johnson et al.
Background: Hemp and cannabidiol (CBD) products are now widely available for purchase in the United States and in many international jurisdictions. However, these products are largely unregulated (with very few exceptions) and are widely av...
Effect of Heat Processing on Major Psychoactive Compounds and Total Phenolic Content in Psychotropic Plants: Cannabis (Cannabis Sativa) and Kratom (Mitragyna Speciosa) Leaves [0.03%]
加热处理对致幻植物中主要精神活性化合物和总酚含量的影响：大麻（大麻素）和 kratom（Speciosa）叶子的影响
Wimonphan Chathiran,Laura Varatojo,Jaruwan Chimasangkanan et al.
Wimonphan Chathiran et al.
Background: Several countries have legalized cannabis (Cannabis sativa) and kratom (Mitragyna speciosa), increasing accessibility to these psychotropic plants for medicinal and recreational purposes. Cooking is a popular method to utilize c...
Correct Recognition and Appeal Ratings of Copycat Cannabis Edible Packaging: Evidence from an Online Experiment [0.03%]
克隆型大麻食品包装的正确识别及其吸引力：基于在线实验的证据
Michael Cooper,Yuyan Shi
Michael Cooper
Introduction: Despite prohibitions against youth-appealing packages, deceptive "copycat" cannabis edible packages have been commonly seen in U.S. states that legalized recreational cannabis. Copycat packages mimic the branding features of p...
Cannabidiol Pretreatment Reduces Status Epilepticus and Glutamate Uptake Induced by Kainic Acid in Adult Zebrafish [0.03%]
大麻二酚预处理可减少氯化氪酸诱导的成年斑马鱼癫痫持续状态和谷氨酸摄取
Karolyne de Pieri Pickler,Ana Caroline Salvador de Farias,Guilherme Lodetti et al.
Karolyne de Pieri Pickler et al.
Background: Epilepsy is a neurological chronic disorder that affects about 70 million people worldwide. Status epilepticus (SE) are neural disturbances that cause intense glutamatergic excitatory discharges that modulate changes in normal b...
Feasibility and Tolerability of Nabilone for the Treatment of Obesity: A Randomized Controlled Pilot Trial [0.03%]
纳博灵治疗肥胖症的可行性及耐受性：一项随机对照试点试验
Justin Matheson,Dominique Tertigas,Saima Malik et al.
Justin Matheson et al.
Introduction: In epidemiological studies, people who use cannabis have a lower prevalence of obesity. Furthermore, the endocannabinoid system is recognized as a potential target for obesity treatment and partial agonism of the cannabinoid t...
Cost-Effectiveness of Medical Cannabis Versus Opioids for Chronic Noncancer Pain [0.03%]
大麻类药物与阿片类药物治疗慢性非癌痛的成本效益分析
Haron M Jeddi,Jason W Busse,Behnam Sadeghirad et al.
Haron M Jeddi et al.
Background: Chronic noncancer pain (CNCP) affects one in five adults and is commonly managed with long-term opioid therapy. Concerns regarding rare but catastrophic harms associated with opioids, including overdose and death, have generated...
Acid-Catalyzed Conversion of Cannabidiol to Tetrahydrocannabinols: En Route to Demystifying Manufacturing Processes and Controlling the Reaction Outcomes [0.03%]
CBD到 THC的酸催化转化：揭秘制造过程和控制反应结果之旅
Alex Nivorozhkin,Michael G Palfreyman
Alex Nivorozhkin
Background: Over the last decade, there has been a significant increase in the production of multiple tetrahydrocannabidiol (THC) related products via the acid catalysis of cannabidiol (CBD). The widespread availability of CBD and the unreg...
Health Care Providers' Knowledge, Attitudes, and Practices Toward Medicinal Cannabis: The Case of Lebanon [0.03%]
医疗保健人员对医用大麻的认知、态度和行为：来自黎巴嫩的案例
Bassima Hazimeh,Ibrahim Bou-Orm,Mohamad Mroueh et al.
Bassima Hazimeh et al.
Background: In 2020, the Lebanese parliament legalized cannabis for medical and industrial use, sparking diverse reactions among health care professionals (HCP). Few studies have been conducted to reflect the position of HCP on the topic, a...
Pharmacokinetics and Bioavailability of Cannabinoids Administered via a Novel Orobuccal Nanoparticle Formulation (NanoCelle™) in Patients with Advanced Cancer [0.03%]
通过新型口腔纳米颗粒配方（NanoCelle™）给药的大麻素的药代动力学和生物利用度在晚期癌症患者中的研究
Stephanie E Reuter,Hayley B Schultz,Andrew J McLachlan et al.
Stephanie E Reuter et al.
Introduction: The administration of cannabinoids for disease and symptom management such as pain continues to elicit significant interest, albeit limited information that is available regarding their pharmacokinetics and pharmacodynamics to...