Pharmacological Characterization of the Endocannabinoid Sensor GRABeCB2.0 [0.03%]
新型内源大麻素感受器GRABeCB2.0的功能表征研究
Simar Singh,Dennis Sarroza,Anthony English et al.
Simar Singh et al.
Introduction: The endocannabinoids (eCBs), 2-arachidonoylglycerol (2-AG) and arachidonoyl ethanolamine (AEA), are produced by separate enzymatic pathways, activate cannabinoid (CB) receptors with distinct pharmacological profiles, and diffe...
Prevalence and Frequency of Cannabis Use Among Adults Ages 50-80 in the United States [0.03%]
美国50-80岁成人使用大麻的流行率和频率
Anne C Fernandez,Lara Coughlin,Erica S Solway et al.
Anne C Fernandez et al.
Introduction: Legal access to and attitudes toward cannabis are changing rapidly. Most of the United States and territories allow adults to use medical and/or recreational cannabis. Recent trends demonstrate increasing cannabis use among ol...
Cannabidiol Anticonvulsant Effects Against Lithium-Pilocarpine-Induced Status Epilepticus in Male Rats Are Mediated by Neuroinflammation Modulation and Cannabinoids 1 (CB1), But Not CB2 and GABAA Receptors [0.03%]
大麻二酚通过调节神经炎症和大麻素受体1而不是大麻素受体2和GABAA受体对抗雄性大鼠利培酮-毛果芸香碱诱导的癲痫状态的抗惊厥作用
Mahla Masoumi,Mohammad Amin Manavi,Razieh Mohammad Jafari et al.
Mahla Masoumi et al.
Background: Status epilepticus (SE) is a series of seizures that can lead to serious neurological damages. Cannabidiol (CBD) is extracted from the cannabis plant, which has been approved as an antiseizure medication. This study aimed to det...
Edward Chesney,Will Lawn,Philip McGuire
Edward Chesney
Introduction: Cannabis use is common in people with psychotic disorders and is associated with the exacerbation of symptoms, poor treatment adherence, and an increased risk of relapse. Accurate assessment of cannabis use is thus critical to...
Cannabis Vape Product Sales in California Following CDC's Initial Advisory About Lung Injuries [0.03%]
美国疾控中心发布关于肺损伤的初步警示后加州大麻电子雾化产品的销售额变化
David S Timberlake,Tim A Bruckner,Cornelia Pechmann et al.
David S Timberlake et al.
Introduction: The 2019 outbreak of e-cigarette or vaping product use-associated lung injury (EVALI) is believed to have been caused by vitamin E acetate, an additive used in some cannabis vaporizer products. Previous studies have primarily ...
A Survey Study of Individuals Using Hexahydrocannabinol Cannabis Products: Use Patterns and Perceived Effects [0.03%]
关于使用六氢大麻酚大麻产品的个人的调查研究：使用模式和感知效果
Morgan L Ferretti,L Riley Gournay,Mia G Bingaman et al.
Morgan L Ferretti et al.
Introduction: Across the cannabis market, multiple cannabinoids have seen rapid growth. Considering the differing effects between specific cannabinoids, it is critical to assess effects on an individual level. Hexahydrocannabinol (HHC) is o...
Complex Regional Pain Syndrome Type I: Evidence for the CB1 and CB2 Receptors Immunocontent and Beneficial Effect of Local Administration of Cannabidiol in Mice [0.03%]
I型复杂区域疼痛综合征：CB1和CB2受体免疫含量的证据及大麻二酚局部给药对小鼠的有益作用
Alexandre C Buffon,Daiana C Salm,Ana C Heymanns et al.
Alexandre C Buffon et al.
Introduction: Complex regional pain syndrome type I (CRPS-I) is a debilitating neuropathic painful condition associated with allodynia, hyperalgesia, sudomotor and/or vasomotor dysfunctions, turning investigation of its pathophysiology and ...
Cannabidiol Mitigates Lipopolysaccharide-Induced Pancreatic Pathology: A Promising Therapeutic Strategy [0.03%]
大麻二酚缓解脂多糖诱导的胰腺病理损伤：一种有前景的治疗策略
Senay Topsakal,Ozlem Ozmen,Nasif Fatih Karakuyu et al.
Senay Topsakal et al.
Background: Lipopolysaccharides (LPSs) are a component of certain types of bacteria and can induce an inflammatory response in the body, including in the pancreas. Cannabidiol (CBD), a nonpsychoactive compound found in cannabis, has been sh...
Kristofer Svendsen,Keith A Sharkey,Christophe Altier
Kristofer Svendsen
Cannabis and cannabis products are becoming increasingly popular options for symptom management of inflammatory bowel diseases, particularly abdominal pain. While anecdotal and patient reports suggest efficacy of these compounds for these c...
Effects of Cannabidiol on the Functions of Chimeric Antigen Receptor T Cells in Hematologic Malignancies [0.03%]
大麻二酚对血液系统肿瘤嵌合抗原受体T细胞功能的影响
Natthida Chantarat,Kristine Cate S Pe,Koramit Suppipat et al.
Natthida Chantarat et al.
Introduction: CD19-chimeric antigen receptor (CAR) T cell therapy is a promising immunotherapy for cancer treatment that has shown remarkable clinical responses, leading to approval by the FDA for relapsed and refractory B cell hematologica...