Eric O Potma,David Knez,Martin Ettenberg et al.
Eric O Potma et al.
Recent work on mid-infrared (MIR) detection through the process of non-degenerate two-photon absorption (NTA) in semiconducting materials has shown that wide-field MIR imaging can be achieved with standard Si cameras. While this approach en...
Yuheng Jiao,Yuchen R He,Mikhail E Kandel et al.
Yuheng Jiao et al.
Quantitative phase imaging (QPI) has been widely applied in characterizing cells and tissues. Spatial light interference microscopy (SLIM) is a highly sensitive QPI method due to its partially coherent illumination and common path interfero...
Orthogonalization of far-field detection in tapered optical fibers for depth-selective fiber photometry in brain tissue [0.03%]
用于大脑组织深度选择性光纤光度计的渐变光纤远场检测正交化方法
Marco Bianco,Marco Pisanello,Antonio Balena et al.
Marco Bianco et al.
The field of implantable optical neural interfaces has recently enabled the interrogation of neural circuitry with both cell-type specificity and spatial resolution in sub-cortical structures of the mouse brain. This generated the need to i...
Patrick A Stockton,Keith A Wernsing,Jeffrey J Field et al.
Patrick A Stockton et al.
We introduce a new form of tomographic imaging that is particularly advantageous for a new class of super-resolution optical imaging methods. Our tomographic method, Fourier Computed Tomography (FCT), operates in a conjugate domain relative...
Coherent Raman scattering imaging with a near-infrared achromatic metalens [0.03%]
近红外无色金属透镜的相干拉曼散射成像
Peng Lin,Wei Ting Chen,Kerolos M A Yousef et al.
Peng Lin et al.
Miniature handheld imaging devices and endoscopes based on coherent Raman scattering are promising for label-free in vivo optical diagnosis. Toward the development of these small-scale systems, a challenge arises from the design and fabrica...
Label-free colorectal cancer screening using deep learning and spatial light interference microscopy (SLIM) [0.03%]
基于深度学习和空间光干涉显微镜的无标签结直肠癌筛查技术
Jingfang Kelly Zhang,Yuchen He,Nahil Sobh et al.
Jingfang Kelly Zhang et al.
Current pathology workflow involves staining of thin tissue slices, which otherwise would be transparent, followed by manual investigation under the microscope by a trained pathologist. While the hematoxylin and eosin (H&E) stain is well-es...
Super-resolution localization microscopy: Toward high throughput, high quality, and low cost [0.03%]
超分辨率定位显微技术：朝向高通量、高质量和低成本
Hongqiang Ma,Yang Liu
Hongqiang Ma
After nearly 15 years since its initial debut, super-resolution localization microscopy that surpasses the diffraction-limited resolution barrier of optical microscopy has rapidly gotten out of the ivory tower and entered a new phase to add...
Label-free screening of brain tissue myelin content using phase imaging with computational specificity (PICS) [0.03%]
基于相位成像的脑组织髓鞘含量筛选技术研发
Michael Fanous,Chuqiao Shi,Megan P Caputo et al.
Michael Fanous et al.
Inadequate myelination in the central nervous system is associated with neurodevelopmental complications. Thus, quantitative, high spatial resolution measurements of myelin levels are highly desirable. We used spatial light interference mic...
Label-free image-encoded microfluidic cell sorter with a scanning Bessel beam [0.03%]
无标签图像编码微流体细胞分选器采用扫描贝塞尔光束
Xinyu Chen,Lauren Waller,Jiajie Chen et al.
Xinyu Chen et al.
The microfluidic-based, label-free image-guided cell sorter offers a low-cost, high information content, and disposable solution that overcomes many limitations in conventional cell sorters. However, flow confinement for most microfluidic d...
Simultaneous label-free autofluorescence-multiharmonic microscopy and beyond [0.03%]
共聚焦无标记自体荧光-多谐波显微成像技术及应用研究进展
Stephen A Boppart,Sixian You,Lianhuang Li et al.
Stephen A Boppart et al.
Without sophisticated data inversion algorithms, nonlinear optical microscopy can acquire images at subcellular resolution and relatively large depth, with plausible endogenous contrasts indicative of authentic biological and pathological s...