Mrinalini Tiwari,Suhel Parvez,Paban K Agrawala
Mrinalini Tiwari
The current review gives a brief account of the DNA damage response pathway and involvement of various epigenetic mechanisms in DNA damage response pathway. The main focus is on histone modifications leading to structural alterations in chr...
Systematic analysis of DNA damage induction and DNA repair pathway activation by continuous wave visible light laser micro-irradiation [0.03%]
连续波可见光激光微照射诱导DNA损伤及活化DNA修复途径的系统分析
Britta Muster,Alexander Rapp,M Cristina Cardoso
Britta Muster
Laser micro-irradiation can be used to induce DNA damage with high spatial and temporal resolution, representing a powerful tool to analyze DNA repair in vivo in the context of chromatin. However, most lasers induce a mixture of DNA damage ...
A search for the common ground between Tic; Obsessive-compulsive and Autism Spectrum Disorders: part I, Tic disorders [0.03%]
抽动障碍、强迫症和自闭谱系障碍的共同点研究（上）——抽动障碍部分
Jarrett Barnhill,James Bedford,James Crowley et al.
Jarrett Barnhill et al.
This article is the first of four articles designed to explore the complex interrelationship between Autism Spectrum Disorders (ASD); Obsessive compulsive and Related Disorders (OCRD) and Tic Disorders/Tourette's Syndrome (TD/TS). We begin ...
Usman Mahmood,David W Johnson,Magid A Fahim
Usman Mahmood
Cardiovascular disease is the major cause of death, accounting for approximately 40 percent of all-cause mortality in patients receiving either hemodialysis or peritoneal dialysis. Cardiovascular risk stratification is an important aspect o...
Expression characterization and functional implication of the collagen-modifying Leprecan proteins in mouse gonadal tissue and mature sperm [0.03%]
鼠生殖组织和成熟精子中的胶原修饰蛋白Leprecan的表达特征及其功能意义
Sarah M Zimmerman,Roberta Besio,Melissa E Heard-Lipsmeyer et al.
Sarah M Zimmerman et al.
The Leprecan protein family which includes the prolyl 3-hydroxylase enzymes (P3H1, P3H2, and P3H3), the closely related cartilage-associated protein (CRTAP), and SC65 (Synaptonemal complex 65, aka P3H4, LEPREL4), is involved in the post-tra...
Unfolding of core nucleosomes by PARP-1 revealed by spFRET microscopy [0.03%]
利用spFRET显微镜揭示PARP-1对核心核小体的展开作用
Daniel C Sultanov,Nadezhda S Gerasimova,Kseniya S Kudryashova et al.
Daniel C Sultanov et al.
DNA accessibility to various protein complexes is essential for various processes in the cell and is affected by nucleosome structure and dynamics. Protein factor PARP-1 (poly(ADP-ribose)polymerase 1) increases the accessibility of DNA in c...
Both RAD5-dependent and independent pathways are involved in DNA damage-associated sister chromatid exchange in budding yeast [0.03%]
辐射依赖RAD5的两条途径都参与了酵母DNA损伤相关的姐妹染色单体交换
Michael T Fasullo,Mingzeng Sun
Michael T Fasullo
Sister chromatids are preferred substrates for recombinational repair after cells are exposed to DNA damage. While some agents directly cause double-strand breaks (DSBs), others form DNA base adducts which stall or impede the DNA replicatio...
Sandra Rugonyi
Sandra Rugonyi
Congenital heart defects are the most common malformations in humans, affecting approximately 1% of newborn babies. While genetic causes of congenital heart disease have been studied, only less than 20% of human cases are clearly linked to ...
Non-autonomous consequences of cell death and other perks of being metazoan [0.03%]
细胞死亡的非自主后果及作为多细胞生物的其他优势
Tin Tin Su
Tin Tin Su
Drosophila melanogaster remains a foremost genetic model to study basic cell biological processes in the context of multi-cellular development. In such context, the behavior of one cell can influence another. Non-autonomous signaling among ...
Allelic Interaction between CRELD1 and VEGFA in the Pathogenesis of Cardiac Atrioventricular Septal Defects [0.03%]
CRELD1与VEGFA的等位基因互作在心内膜垫发育缺陷中的致病机制研究
Jennifer K Redig,Gameil T Fouad,Darcie Babcock et al.
Jennifer K Redig et al.
Atrioventricular septal defects (AVSD) are highly heritable, clinically significant congenital heart malformations. Genetic and environmental modifiers of risk are thought to work in unknown combinations to cause AVSD. Approximately 5-10% o...