Structure-Based Optimization of Triazole-Linked Sesamol Conjugates as Antifungal Agents Targeting CYP51 in Candida albicans [0.03%]
基于结构的优化三唑连接雌酚衍生物共轭物作为抗真菌剂 targeting Candida albicans中的CYP51
Karanvir Singh,Atamjit Singh,Rahul Sharma et al.
Karanvir Singh et al.
The increasing prevalence of azole-resistant Candida albicans due to extensive and irrational use of antifungal agents demands the development of new selective and effective antifungal agents. Here, we designed a series of triazole-linked s...
Growth-Inhibitory Activity of a Clerodane Diterpene from Callicarpa americana Leaf Extracts and Its Derivatives against Cutibacterium acnes [0.03%]
美国翅子树树叶提取物中的 clerodane 二萜及其衍生物抑制Cutibacterium acnes增殖的作用
Ben Kittleson,Sunmin Woo,Lewis Marquez et al.
Ben Kittleson et al.
Cutibacterium acnes is a Gram-positive bacterium implicated in acne vulgaris, a common inflammatory skin disease. Rising antibiotic resistance in C. acnes highlights the need for new therapeutic agents. Callicarpa americana L., a shrub nati...
Rational Design and Screening of Chemically Modified Anti-SARS-CoV-2 siRNA [0.03%]
化学修饰的抗SARS-CoV-2 siRNA理性设计与筛选
Zihui Cheng,Ying Cai,Enhua Zhang et al.
Zihui Cheng et al.
To realize the therapeutic potential of RNA interference against severe acute respiratory syndrome coronavirus 2, strategic chemical modifications are crucial for enhancing the siRNA stability and potency. In this study, 200 siRNAs were scr...
A Rapid and Ultrasensitive Detection of Coxsackievirus A16 Using Reverse Transcription Multiple Cross Displacement Amplification Combined with the CRISPR-Cas12a-Based Biosensing System [0.03%]
一种快速灵敏检测肠病毒A16型的逆转录多重交叉置换扩增联合CRISPR-Cas12a系统的方法
Qi Liang,Yumei Cao,Xujian Zhang et al.
Qi Liang et al.
Coxsackievirus A16 (CVA16) is one of the primary viral etiological agents of hand, foot, and mouth disease (HFMD) in infants and children under five years of age. Prompt and reliable detection of CVA16 is crucial for guiding immediate thera...
Argonaute Integrated with Nanoparticle-Based Biosensor for Portable, Visual, and Rapid Detection of Neisseria gonorrhoeae in Clinical Application [0.03%]
一种用于临床快速、便携和可视检测淋病奈瑟氏球菌的基于纳米颗粒生物传感器与 Argonaute 相集成的方法
Yanyan Qin,Ling Xie,Cencen Jia et al.
Yanyan Qin et al.
Sexually transmitted gonorrhea infection is a key worldwide public health issue, especially in low- and middle-income areas. The quest for ultrasensitive, highly specific, rapid, and accessible diagnostics for Neisseria gonorrhoeae is a cri...
Role of N-Glycosylation in SARS-CoV-2 Spike Glycoprotein Conformational Dynamics, Structure, and Function [0.03%]
N-糖基化在SARS-CoV-2刺突糖蛋白构象动力学、结构和功能中的作用
Sarah H Osman,Christopher A Haynes,Adrian R Woolfitt et al.
Sarah H Osman et al.
The SARS-CoV-2 spike protein is heavily glycosylated. These post-translational modifications aid in interactions with human angiotensin-converting enzyme 2 (hACE2), assist in antibody evasion, and help facilitate protein dynamics. However, ...
Structural and Kinetic Variability of Pathogen Cyclophilins: Functional Diversification and Therapeutic Potential [0.03%]
病原体环素蛋白的结构和动力学变异性：功能多样化及治疗潜力
Filippo Favretto,Eva Jiménez-Faraco,Silvia Fruncillo et al.
Filippo Favretto et al.
Cyclophilins are a highly conserved family of peptidyl-prolyl cis-trans isomerases (PPIases) that play essential roles in protein folding, trafficking, and cellular stress adaptation across all domains of life. While extensively studied in ...
Drug Discovery of Antiviral Inhibitors Targeting Dengue Virus NS4B Protein [0.03%]
针对登革病毒NS4B蛋白的抗病毒抑制剂药物发现
Sikun Pang,Xinhui Qiu,Ziyin Cai et al.
Sikun Pang et al.
Dengue virus (DENV) infection represents a rapidly growing global public health burden for which no approved antiviral therapies are currently available. Among the viral nonstructural proteins, NS4B has emerged as a particularly compelling ...
Pieter S Hiemstra
Pieter S Hiemstra
Antimicrobial peptides (also known as host defense peptides; HDPs) have been a topic of intense research in the past decades, stimulated by the rise in antibiotic resistance. This Viewpoint article highlights the contribution of Robert E. W...
Mycobacterium avium: Diversity, Clinical Significance, Old and New Targeted Medicines [0.03%]
鸟分枝杆菌：多样性、临床意义及传统和新型治疗药物
Thanh Quang Nguyen,Franck Biet,Marcel A Behr et al.
Thanh Quang Nguyen et al.
The Mycobacterium avium complex (MAC) comprises opportunistic pathogens of growing clinical significance, particularly in immunocompromised individuals and aging populations. Advances in molecular genomics have refined MAC taxonomy, enablin...