Large-Scale Chemical-Genetic Interaction Profiling Identifies a Small-Molecule Inhibitor of Mycobacterium tuberculosis Polyketide Synthase 13 [0.03%]
大规模化学基因组相互作用分析鉴定出一种分枝杆菌聚酮合酶13小分子抑制剂
James E Gomez,Matthew Y Solomon,Diana K Hunt et al.
James E Gomez et al.
PROSPECT (PRimary screening Of Strains to Prioritize Expanded Chemistry and Targets) is an antimicrobial discovery platform based on chemical-genetic interaction profiling of compounds against a pool of Mycobacterium tuberculosis (Mtb) hypo...
Revealing the Fate of Isomeric Monounsaturated Fatty Acids in Enterococcus faecalis Membrane Lipids and Their Influence on Antimicrobial Susceptibility [0.03%]
肠球菌门膜脂质中顺式和反式单不饱和脂肪酸的命运及其对抗微生物敏感性的影响
Rebekah L Casey,Annika L Silverberg,Michael T Marty et al.
Rebekah L Casey et al.
Previous work suggests that Enterococcus faecalis uses exogenous oleic acid (FA 18:1(9z)) to increase its tolerance against the membrane-targeting antimicrobial, daptomycin. However, the specific roles of OA and the endogenous positional is...
LABCG1 Affects Leishmania (Leishmania) Amazonensis Infectivity but Not Virulence or Sand Fly Infection [0.03%]
LABCG1影响亚马逊利什曼原虫的感染性但不影响毒力或按蚊感染
Gustavo Rolim Barbosa,Gustavo Henrique Correa Soares,Taina Cavalcante et al.
Gustavo Rolim Barbosa et al.
Leishmaniases are a complex spectrum of diseases caused by protozoan parasites of the genus Leishmania. Overall, they can be classified into two main clinical forms: tegumentary and visceral leishmaniasis (TL and VL, respectively). Our grou...
Oxadiazolone Derivatives: Powerful Tools to Reduce Staphylococcus aureus Infection [0.03%]
恶二唑酮衍生物：减少金黄色葡萄球菌感染的有力工具
Emma Forest,Jordan Lehoux,Léo Faion et al.
Emma Forest et al.
Staphylococcus aureus is a Gram-positive opportunistic pathogen and a top priority bacterium in the fight against antimicrobial resistance. Its high propensity to develop resistance, its high virulence, and its ability to form biofilms and ...
Computer-Aided Discovery of Small-Molecule Inhibitors of Pathogenic New World Arenavirus Entry and Replication [0.03%]
计算辅助发现小分子抑制病原新世界 Arenavirus 入侵和复制的抑制剂
Samantha Rae Wasson,Ben Matthew Flude,Martina Salerno et al.
Samantha Rae Wasson et al.
Pathogenic New World arenaviruses (NWAs), including Junín (JUNV) and Machupo (MACV) viruses, rely on host-virus entry processes that represent attractive points for antiviral intervention. Guided by the known use of human transferrin recep...
Acyclic Nucleoside Phosphonate Prodrug LAVR-289 Inhibits Marek's Disease Virus Replication [0.03%]
无环核苷膦酸盐前药LAVR-289可抑制马立克氏病病毒增殖
Chloé Styranec,Vincent Roy,Luigi A Agrofoglio et al.
Chloé Styranec et al.
Since the 1970s, numerous antivirals targeting human herpesviruses have been developed, yet their application in veterinary medicine remains limited due to poor bioavailability and significant toxicity in animals. Recently, LAVR-289, a nove...
Glutamine Potentiates Cefoperazone-Sulbactam against Klebsiella pneumoniae by Enhancing Cellular Uptake and ROS Production [0.03%]
谷氨酰胺通过增强细胞摄取和ROS生成来增强第三代头孢类抗生素-舒巴坦对肺炎克雷伯氏菌的作用
Shao-Hua Li,Yu-Yan Chen,Huan-Zhe Fu et al.
Shao-Hua Li et al.
Antibiotic-resistant Klebsiella pneumoniae poses a serious global challenge to clinical practice and public health, highlighting an urgent need for effective therapeutic strategies. This study systematically evaluated the preclinical pharma...
Thomas R Lane,Olivier Escaffre,Lihong Zhang et al.
Thomas R Lane et al.
Nipah virus (NiV) and Hendra virus (HeV) are bat-borne zoonotic paramyxoviruses that cause severe and often fatal respiratory and neurological disease in humans, for which no small-molecule therapies are currently approved. While host-prote...
Beyond Inhibition: Sublethal Rifampicin-Induced Molecular Adaptations Confer Phenotypic Drug Tolerance in Mycobacteria [0.03%]
抑菌之外：利福平诱导的分子适应使分枝杆菌产生表型耐药性
Blake D Stuart,Anja van der Merwe,Melissa D Chengalroyen et al.
Blake D Stuart et al.
Tuberculosis (TB) remains a major global health threat, largely due to Mycobacterium tuberculosis (Mtb) resilience, which can be exacerbated by exposure to sublethal antibiotic concentrations arising from factors such as patient nonadherenc...
Role of Ambler Position 104 in Defining Substrate Specificity in the KPC Family of β-Lactamases [0.03%]
Ambler位点104在KPC类β内酰胺酶底物特异性中的作用
Lin Gao,Steven Marshall,Christopher R Bethel et al.
Lin Gao et al.
Carbapenem-resistant Gram-negative bacteria pose a critical clinical challenge, largely due to the dissemination of class A Klebsiella pneumoniae carbapenemases (KPCs). Residue 104 in the α3-α4 loop of KPC enzymes forms part of a hydropho...