Legacy 4(1 H)-Quinolone Scaffolds Activity against Acute and Chronic Toxoplasma gondii Infection [0.03%]
具有抗急性及慢性刚地梭菌感染活性的4(1H)喹诺酮骨架化合物系列
Melissa A Sleda,Khaly Diagne,Victoria Mills Clifton et al.
Melissa A Sleda et al.
Toxoplasma gondii is a protozoan parasite capable of infecting most warm-blooded animals, including humans, and can cause severe disease in immunocompromised individuals and the developing fetus. Current treatments for toxoplasmosis are eff...
Efficacy, Structure-Activity Relationship, and Mode of Action Studies of a New Generation of Acridine/Acridone-Based Antimalarials [0.03%]
一类新型吖啶/吖啶酮类抗疟药的体内活性、构效关系及其作用机制研究
Sarah El Chamy Maluf,Giovana Rossi Mendes,Igor M R Moura et al.
Sarah El Chamy Maluf et al.
Malaria continues to devastate humanity with significant global morbidity and mortality. The emerging resistance to antimalarials suggests artemisinin and its derivatives will encounter the same challenges as other antimalarial drugs. Strat...
Lipid Mediators in Host-Pathogen Interactions during Leishmania Infection: Friends or Foes? [0.03%]
利什曼原虫感染期间宿主病原相互作用中的脂类介体：伙伴还是对手？
Yasmin Monara Ferreira de Sousa Andrade,Darlaine Alves Silva,Tainá Larissa Pires Nascimento et al.
Yasmin Monara Ferreira de Sousa Andrade et al.
Lipid mediators can control the inflammatory response in infectious diseases, including leishmaniasis. However, these mediators may promote antagonistic roles in the Leishmania-host interaction depending on the species involved in the infec...
Photodynamic Inactivation of Hypervirulent Acinetobacter baumannii via a Trojan Horse Strategy Targeting Heme Acquisition Pathway [0.03%]
利用针对血红素获取途径的特洛伊木马策略光动力灭活高毒力鲍曼不动杆菌
Viet Q Nguyen,Hiroshi Sugimoto,Osami Shoji
Viet Q Nguyen
Multidrug-resistant (MDR) pathogens pose a major threat to global health, and novel therapeutics are urgently needed to combat the rapid evolution of antimicrobial resistance. Acinetobacter baumannii is one of the notorious MDR pathogens as...
Legionella pneumophila Encodes a Peptidoglycan Recycling Machinery Critical for Survival within Macrophages [0.03%]
利福利亚嗜肺军团菌编码一种肽聚糖循环利用装置对巨噬细胞内生存至关重要
Sushanta Ratna,Aastha Acharya,Miranda E Roland et al.
Sushanta Ratna et al.
Bacterial cells are surrounded by a dynamic cell wall which is made up of a mesh-like peptidoglycan (PG) layer that provides the cell with structural integrity and resilience. In Gram-positive bacteria, this layer is thick and robust, where...
F2F-202, a Selective Histone Deacetylase 6 (HDAC6) Inhibitor, Behaves as an Arrow with Multiple Tips against Azole-Resistant C. albicans: Modulation of Yeast-to-Hyphae Transition, Trailing Effect, and Oxidative Stress [0.03%]
F2F-202，一种选择性组蛋白去乙酰酶6 (HDAC6) 抑制剂，可作为多头箭矢对抗唑类耐药的白色念珠菌：调节酵母-菌丝转变、延续效应和氧化应激
Simona Barone,Baptiste Mateu,Marialuisa Piccolo et al.
Simona Barone et al.
Fungal infections are increasingly threatening public health due to the onset of multidrug-resistant fungal strains. Accordingly, the incidence of chemoresistant C. albicans strains has steadily increased, along with associated mortality, t...
A Dibenzo- p-dioxin-Shaped New Chemotype of Glycopeptide Antibiotic Active against Drug-Resistant Pathogens [0.03%]
一种新型糖肽抗生素的抗药耐药病原体活性及独特双苯并二氧六环母核骨架结构研究
Xingkun Li,Mengru Wang,Lixin Yin et al.
Xingkun Li et al.
Glycopeptide antibiotics (GPAs) are the drugs of "last resort" for treating multidrug-resistant Gram-positive infections such as methicillin-resistant Staphylococcus aureus and enterococci. Unfortunately, GPAs are vulnerable to resistance a...
Design, Synthesis, and Evaluation of Novel Thiazole-Based Peptidomimetic Compounds as Potent SARS-CoV-2 Main Protease Covalent Inhibitors [0.03%]
设计、合成及评估新型噻唑基肽模拟物化合物作为 potent SARS-CoV-2 主蛋白酶共价抑制剂及其作用机制研究
Weile Yin,Wai-Po Kong,Siu-Lun Leung et al.
Weile Yin et al.
The main protease (Mpro) of SARS-CoV-2, essential for the replication of the virus, is a critical target for antiviral drug development. Herein, we developed a series of thiazole-based peptidomimetic compounds to identify potent and selecti...
A Divergent MBL-Fold Metallo-Hydrolase (Kmh-1) from Klebsiella pneumoniae Confers Aztreonam Degradation and Expands the β-Lactamase Landscape [0.03%]
来自肺炎克雷伯菌的发散型金属水解酶（Kmh-1）MBL结构域赋予碳青霉烯类抗生素降解能力并扩展β-内酰胺酶图谱
Jyoti Barman,Partho Biswas,Partha Roy et al.
Jyoti Barman et al.
The widespread use and misuse of β-lactam antibiotics exert selective pressure on bacteria, driving the continuous emergence of novel metallo-β-lactamases (MBLs). Characterizing newly evolved MBLs is critical for elucidating the molecular...
Identification and Evaluation of Dibasic Piperidines as Cell Wall Inhibitors against Mycobacterium tuberculosis [0.03%]
二氨基哌啶类细胞壁抑制剂的鉴定及评估用于抗结核分枝杆菌
Claire Naylor,Gareth Prosser,Tracy Bayliss et al.
Claire Naylor et al.
Globally, Mycobacterium tuberculosis remains a significant burden. Although effective treatment regimens exist, drug resistance has continued to emerge. This clinical resistance, combined with side effects and protracted treatment times fro...