Cytochrome P450-Mediated Metabolism of Antimycobacterial N α-Aroyl- N-aryl-phenylalanine Amides [0.03%]
抗分枝杆菌剂Nα-芳基-N-芳基-苯丙氨酰胺的细胞色素P450介导代谢作用
Johannes Doering,Erik Meerz,Rüdiger W Seidel et al.
Johannes Doering et al.
Nα-Aroyl-N-aryl-phenylalanine amides (AAPs) are a class of antimycobacterial substances that inhibit the RNA polymerase and are effective against various pathogenic and opportunistic mycobacteria, including Mycobacterium tuberculosis, Myco...
Zhen-Ling Zeng,Yuanyuan Zhang,Xinghong Zhao
Zhen-Ling Zeng
Efavirenz Mitigates Dyslipidemia and Attenuates Ulcerative Colitis through Gut Microbiota Modulation [0.03%]
埃法韦仑通过调节肠道菌群缓解血脂异常和减轻溃疡性结肠炎病情
Wei Wang,Xiaoge Niu,Shasha Li et al.
Wei Wang et al.
Antiretroviral therapy (ART) is central to controlling human immunodeficiency virus (HIV) infection, yet it is frequently associated with dyslipidemia, a condition linked to the exacerbation of ulcerative colitis (UC) in people living with ...
Metabolic Screening of Gut Microbiota by Fourier-Transform Infrared Spectroscopy [0.03%]
基于傅里叶变换红外光谱技术的肠道微生物代谢筛选研究
Anna Sayol-Altarriba,Andrea Aira,Eva Martín-López et al.
Anna Sayol-Altarriba et al.
Short-chain fatty acids (SCFAs) are bacterial metabolites with crucial roles in host homeostasis and immune system modulation. Given their benefits, they have been proposed as markers of healthy microbiota. However, accurate SCFA quantifica...
Antifungal and Antivirulence Activity of Alizarin against Candida dubliniensis [0.03%]
阿尔izarin对都柏林芽生酵母的抗真菌和抗菌活性作用
Ganeshkumar Arumugam,Samuthirapandi Muniasamy,Patricia Michelle Nagai de Lima et al.
Ganeshkumar Arumugam et al.
Candida dubliniensis is a relatively common yet understudied fungal species present in the oral cavity of both healthy and immunocompromised individuals. Despite its increasing clinical relevance, research addressing its pathogenesis and th...
When Second Messenger Signaling Meets Resistance: (p)ppGpp, C-di-GMP and C-di-AMP as Masters of Antibiotic Stress Adaptation [0.03%]
当次信使信号遇到阻力时：(p)ppGpp、C-di-GMP 和 C-di-AMP 作为抗生素胁迫适应的主导者
Arti Rathore,Jyoti Kumari,Shifa Firdous et al.
Arti Rathore et al.
Antimicrobial resistance represents a critical global health challenge, necessitating deeper insights into bacterial regulatory networks that govern adaptive survival and can be exploited as novel targets for drug discovery. Among these, nu...
Convergent Activation of NF-κB and STAT3 Drives Cartilage Degeneration in a Murine Model of BCG-Induced Arthritis [0.03%]
NF-κB和STAT3的汇聚激活可驱动BCG诱导的小鼠关节炎模型软骨损伤的发展
Jiezhong Deng,Jingjin Dai,Pan Liu et al.
Jiezhong Deng et al.
Reactive arthritis induced by Mycobacterium tuberculosis (M.tb) causes severe cartilage degradation, yet the underlying mechanisms remain elusive. This study investigated the molecular mechanisms and potential therapeutic targets for M.tb-i...
Gallium Protoporphyrin and Lipid Crystalline Nanoparticles Promote the Activity of Ampicillin against MRSA [0.03%]
镓原卟啉和脂质结晶型纳米颗粒增强氨苄西林对MRSA的杀菌活性
Muhammed Awad,Sholeh Feizi,Peter-John Wormald et al.
Muhammed Awad et al.
Promoting the effectiveness of antibiotics against multidrug-resistant bacteria is necessary to overcome the global antimicrobial resistance crisis. Methicillin-resistant Staphylococcus aureus (MRSA) is notorious for its β-lactam resistanc...
Synthesis and Assessment of Imidazo-Fused β-Carbolines as Antileishmanial Agents [0.03%]
作为抗利什曼病制剂的咪唑并β-咔啉的合成与评估
Aritra Ghosh,Rupa Hansda,Shweta Bisht et al.
Aritra Ghosh et al.
Visceral leishmaniasis is a life-threatening neglected tropical disease that predominantly affects the liver and spleen. The widespread emergence of drug resistance, along with the continued absence of an effective vaccine, underscores the ...
The Future of Protozoan Infection Research: 3D Cell Culture and beyond [0.03%]
原生动物感染研究的未来：三维细胞培养等技术的发展
Sarah Beatriz de Fucio,Abel Sana,Beatriz Marques et al.
Sarah Beatriz de Fucio et al.
Protozoan infections remain a major challenge to human health, owing to the substantial impact these parasites exert on their hosts. In vitro culture systems are fundamental for elucidating the host-parasite interactions underlying these in...