Coordinated Regulation of TLR2 Signaling by Neu1 Sialidase and the Siglec-5/Siglec-14 Receptor Pair During Mycoplasma pneumoniae Infection [0.03%]
分枝杆菌感染期间Neu1岩藻糖转移酶和Siglec-5/Siglec-14受体对TLR2信号的协同调节作用
Haodang Luo,Qianrui Zeng,Na Xie et al.
Haodang Luo et al.
Mycoplasma pneumoniae is a primary cause of community-acquired pneumonia, characterized by an excessive host inflammatory response that often drives lung pathology. While Toll-like receptor 2 (TLR2) is the principal sensor for this pathogen...
Antigen-Pulsed Dendritic Cell-Derived Dexosomes Induce a Robust Th1-Biased Antigen-Specific Humoral and Cellular Immunity in Mice against Latent Mycobacterium tuberculosis Antigen Rv2626c [0.03%]
负载抗原的树突状细胞衍生的Dexosome诱导针对潜伏结核杆菌抗原Rv2626c特异性体液和细胞免疫响应
Saima Naz,Bandi Dharani,Farhan Ahmed et al.
Saima Naz et al.
Tuberculosis (TB) continues to be a leading health crisis globally, with latent tuberculosis infection (LTBI) affecting approximately 1.7 billion people worldwide. The current BCG vaccine does not provide consistent protection against pulmo...
Using Unbiased Chemical Proteomics Approaches to Explore the Target Landscape of the Resistance Refractory 7-Azaindole MMV022224 in Plasmodium falciparum [0.03%]
采用无偏见化学蛋白质组学方法探讨Pfnek1与氯喹抗性疟原虫中MMV022224的作用靶点格局
Aisha J Syed,Rachel Milne,Victoriano Corpas-Lopez et al.
Aisha J Syed et al.
Current standard of care, artemisinin-based therapies for malaria, are threatened by emerging drug resistance. Developing antimalarials with novel mechanisms of action and low propensity for resistance is of the highest priority. Here, we e...
Candida albicans RLM1 Diversity Regulates Cell Wall Composition and Virulence [0.03%]
白念珠菌RLM1多样性调节细胞壁组成和致病性
Shang-Ting Tsai,I-An Tsai,Bo-Yi Song et al.
Shang-Ting Tsai et al.
Candida albicans RLM1, a transcription factor essential for cell wall integrity, contains a polymorphic CAA/G repeat (poly-Q) associated with recurrent vulvovaginal candidiasis. We aim to investigate how poly-Q repeat variations alter C. al...
Correction to "Mechanistic Insights into the Divergent Membrane Activities of a Viroporin from Chikungunya Virus and Its Transframe Variant" [0.03%]
Correction to "病毒膜活性不同的机制见解——奇克病病毒解离蛋白及其转框变异体的比较研究"
Kirti Suhag,Subhomoi Borkotoky,Shumaila Iqbal Siddiqui et al.
Kirti Suhag et al.
Published Erratum
ACS infectious diseases. 2026 Jun 22. DOI:10.1021/acsinfecdis.6c00570 2026
Minimum Inoculum of Resistance Assay for Evaluating Antitoxoplasmosis Compounds That Target Phenylalanine tRNA Synthetase [0.03%]
评估靶向苯丙氨酰-tRNA合成酶抗托拉螺旋体化合物的最小接种量试验法
Taher Uddin,Payal Mittal,Han Xie et al.
Taher Uddin et al.
Toxoplasma gondii is a globally important intracellular parasite, and treatment regimens are limited by the failure of drugs to target latent tissue cysts. Developing new candidates for treatment also needs to address the potential for resi...
The Novel Carbapenem, JDB/PQ-1-219, Has Potent Broad Spectrum Activity against Multi-Drug Resistant Acinetobacter baumannii [0.03%]
具有广谱活性的新型碳青霉烯JDB/PQ-1-219对抗多重耐药鲍曼不动杆菌的功效强烈
Marta Toth,Nichole K Stewart,Ailiena O Maggiolo et al.
Marta Toth et al.
Carbapenem resistance in Acinetobacter baumannii, driven largely by class D, along with class A and class B β-lactamases, has severely compromised the utility of these last resort antibiotics. As a result, infections caused by such pathoge...
Synthesis and Evaluation of Nitroheterocyclic Aromatic Adamantanohydrazones with Trypanocidal Activity. Part III [0.03%]
具有锥虫细胞毒活性的硝基杂环芳烃组胺酸亚胺的合成与评价（第三部分）
Angeliki-Sofia Foscolos,Konstantina Stavropoulou,Nuno Santarém et al.
Angeliki-Sofia Foscolos et al.
Extending our research on the design, synthesis, and pharmacological evaluation of antitrypanosomatid nitroheterocyclic aromatic adamantanes, we have identified hydrazone derivatives conjugated with 5-nitrothiophene that have submicromolar ...
Indolicidin Attenuates Inflammation by Modulating the TLR4 Signaling Pathway during Sepsis Progression [0.03%]
吲哚基蛋白通过调节败血症进展过程中的TLR4信号通路来减轻炎症反应
Zhishang Shi,Yanting Wang,Yijun Gu et al.
Zhishang Shi et al.
Sepsis is characterized by dysregulated inflammatory responses triggered by pathogen-associated molecular patterns (PAMPs) and remains a major cause of mortality worldwide. Although antibiotics are widely used for the treatment of sepsis-as...
Enhanced Respiratory Electron Dissipation by Immunometabolites Promotes Mycobacterial Biofilm Longevity [0.03%]
免疫代谢物通过增强呼吸电子耗散促进分枝杆菌生物膜的长期存在
Kaushik Poddar,Gunjan Tripathi,Snehal V Khairnar et al.
Kaushik Poddar et al.
Mycobacterial species inhabit diverse ecological niches and frequently adopt a biofilm lifestyle, including within host environments, where this organization critically influences the persistence and pathophysiological outcomes. Here, using...