Influenza A Virus Binding to α,2-3- and α,2-8-Linked Sialo-Gangliosides Reconstituted in Phase-Separated Vesicles [0.03%]
甲型流感病毒与α，2-3-和α，2-8-连接的唾液神经节苷脂重组在相分离囊泡中的结合力研究
Garvita Dhanawat,Manorama Dey,Shriya Agrawal et al.
Garvita Dhanawat et al.
We investigated the binding of influenza A viruses (IAVs) to gangliosides containing either α,2-3- or α,2-8-linked sialic acid residues, or a combination of both. The respective gangliosides were reconstituted into phase-separated giant u...
In Vivo Activity of Antimicrobial Peptoid Oligomers against HSV-1 in a Mouse Model of Herpes Labialis [0.03%]
抗HSV-1肽素寡聚物活体活性模型中的 herpes labialis 研究
Erika L Figgins,Denny Gao,Lisa K Ryan et al.
Erika L Figgins et al.
Herpes simplex virus type-1 (HSV-1) infections cause recurrent oral lesions and are the primary cause of infectious blindness and genital lesions in developed countries. HSV-1 can also lead to life-threatening infections in immunocompromise...
Antimicrobial Peptides and Biofilms: From Molecular Interactions to Therapeutic Control [0.03%]
抗菌肽与生物被膜：从分子相互作用到治疗控制
Jayita Ghosh,Saikat Deb,Moumita Jana et al.
Jayita Ghosh et al.
The rising problem of antimicrobial resistance (AMR), further complicated by the resilience of bacterial biofilms, calls for the discovery of new therapeutic strategies. Bacteria residing in biofilms rely on extracellular polymeric substanc...
Comparative Phenotypic Screening Identifies Protein Synthesis Inhibitors as Compounds That Enhance Early Acidification of Mycobacterium tuberculosis in Macrophages [0.03%]
比较性表型筛选鉴定蛋白合成抑制剂可增强结核杆菌胞内早期酸化为化合物
Leah Rankine-Wilson,Yossef Av-Gay
Leah Rankine-Wilson
Treatments for tuberculosis disease (TB) are failing on a global scale, necessitating new drug discovery efforts to identify effective therapies. Mycobacterium tuberculosis (Mtb), the obligate human pathogen and causative agent of TB, resid...
Correction to " Treponema pallidum Flagellin FlaB3 Activates Inflammation and Inhibits Autophagy in HMC3 Cells via the TLR4 Pathway" [0.03%]
“苍白密螺旋体鞭毛蛋白FlaB3通过TLR4途径激活炎症并抑制自噬”一文的更正
Fangzhi Du,Zhiyu Lu,Qingyun Wu et al.
Fangzhi Du et al.
Published Erratum
ACS infectious diseases. 2026 Jul 1. DOI:10.1021/acsinfecdis.6c00571 2026
Coumarin-Mediated Inhibition of Diadenylate Cyclase Correlates with Impaired Biofilm Formation in Streptococcus mutans [0.03%]
香豆素介导的二腺苷酸环化酶抑制作用与变异链球菌生物膜形成受损相关性研究
Edwin M Rojas,Abhishek Govindan,Parvathy Babu et al.
Edwin M Rojas et al.
Streptococcus mutans diadenylate cyclase (SmDAC) catalyzes the cyclization of two ATP molecules into cyclic di-AMP, a second messenger that regulates many cellular processes including biofilm formation. Aided by structure-based drug design ...
Plasminogen Recruitment by Staphylococcus aureus SdrC Reveals a Tractable Antivirulence Target [0.03%]
金黄色葡萄球菌SdrC募集纤溶酶原揭示了可调控的抗菌靶点
Elisa Bellan Menegussi,Angelica Pellegrini,Laura Acquasaliente et al.
Elisa Bellan Menegussi et al.
Staphylococcus aureus exploits host extracellular matrix components to promote tissue invasion and dissemination. Here, we identify the serine-aspartate repeat protein C (SdrC) as a previously unrecognized plasminogen-binding protein on the...
Suilysin of Streptococcus suis Serotype 2 Drives Astrocyte Pyroptosis via Activation of the ROS/NLRP3/Caspase-1/GSDMD Pathway [0.03%]
败血症链球菌的suilysin通过激活ROS/NLRP3/ caspase-1 /GSDMD信号通路驱动星形胶质细胞焦亡
Ruicheng Yang,Lang Tian,Jundan Wang et al.
Ruicheng Yang et al.
Emerging evidence indicates that pyroptosis contributes to neuroinflammation and central nervous system (CNS) injuries. However, its role in Streptococcus suis (S. suis)-induced brain damage remains unclear. Here, we demonstrate that S. sui...
Influenza Virus-Like Particles Displaying Leishmania donovani Promastigote Surface Antigen Induce Cross-Protective Immunity [0.03%]
表达唐氏利什曼原虫表面抗元的流感病毒样颗粒可诱导交叉保护 immunity
Keon-Woong Yoon,Ki Back Chu,Gi-Deok Eom et al.
Keon-Woong Yoon et al.
Virus-like particles expressing the Promastigote surface antigen (PSA) of Leishmania donovani have shown great potential as a vaccine candidate against L. donovani infection. However, their potential as a cross-protective leishmaniasis vacc...
A Review of Contact Lens-Associated Infections and Biomaterial-Based Solutions [0.03%]
接触镜相关感染及生物材料解决方案综述
Nathan Carey,Desie Kasew Assefa,Yalewayker Asrat et al.
Nathan Carey et al.
Approximately 150 million people worldwide wear contact lenses, and most wear them successfully. However, contact lens wear is a major risk factor for developing infections and inflammation of the eye. This review outlines the need for anti...