Platanosides, a Promising Class of Plant-Derived Antibiotics, Are Effective against a Suite of Clinically Derived MDR and Drug-Sensitive Staph and Strep spp [0.03%]
一种有前景的来源于植物的抗生素Platanoside类物质对一系列临床分离的耐多药和药物敏感的葡萄球菌和链球菌有效
Cody F Dickinson,Menny M Benjamin,Ahmed Alford et al.
Cody F Dickinson et al.
Systemic multidrug-resistant bacterial infections have become a global public health priority due to the diminished efficacy of standard antibiotic regimens and can lead to sepsis, which is among the leading causes of death (11 million/year...
Strathclyde Minor Groove Binders Bearing Amidine Tail Groups are Effective against Gram-Positive Bacterial Pathogens [0.03%]
含有脒基尾团的斯特拉斯克莱德类minor groove binders对革兰氏阳性细菌病原体有效
Charlotte K Hind,Kaveh Eskandari,Leah M C McGee et al.
Charlotte K Hind et al.
The rise of multidrug-resistant Gram-positive pathogens necessitates new antibacterial agents with mechanisms that are distinct from those of existing therapies. Here, we report the antibacterial activity and mechanistic characterization of...
Total Synthesis and Antibacterial Evaluation of (-)- and (+)- epi-Perrottetinene [0.03%]
(-)-和(+)-epi-松香烷的全合成及抗菌评价
Vijay Kumar,Anjali Gangwar,Sunandhani Khajuria et al.
Vijay Kumar et al.
Antimicrobial resistance (AMR) is a critical threat to global public health, with emerging resistance to Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA), often referred to as a silent pandemic. Despite ongoing effort...
Correction to "Peptide Dendrimer-Based Antibacterial Agents: Synthesis and Applications" [0.03%]
关于“基于肽型树状高分子的抗菌剂：合成与应用”的更正通知
Suchita Paul,Sandeep Verma,Yu-Chie Chen
Suchita Paul
Published Erratum
ACS infectious diseases. 2026 Jul 13. DOI:10.1021/acsinfecdis.6c00594 2026
Insights into the Structure and Function of the OTU Protease Virulence Factors from Emerging Human Nairoviruses [0.03%]
新兴人类奈病毒OTU脱毒因子结构与功能的见解
David S Gonzalez,Amritpal Jalf,Vanessa Moresco et al.
David S Gonzalez et al.
Tick-borne negative-sense single-stranded RNA nairoviruses represent a significant global public-health threat. Over the past decade, discoveries of new orthonairoviruses and norwaviruses have surged. Many of these have been observed to cau...
Antimicrobial α-Peptoids/Polypeptoids: Molecular Design and Therapeutic Assemblies [0.03%]
抗菌α-肽索/聚肽索：分子设计与治疗组装
Mengyuan Hu,Yiyu Gong,Hailing Han et al.
Mengyuan Hu et al.
The global health crisis of antibiotic-resistant bacteria necessitates the development of novel antimicrobial agents. Natural antimicrobial peptides (AMPs) represent a promising therapeutic strategy, but their susceptibility to proteolytic ...
2-Amino-3,4-Dihydroquinazolines Exhibit Potent Antimalarial Activity by Targeting Plasmepsin X [0.03%]
2-氨基-3,4-二氢喹唑啉通过靶向血疟原虫半乳糖苷酶展示出抗疟活性
Madeline G Dans,Jon Kyle Awalt,Nghi Nguyen et al.
Madeline G Dans et al.
The emergence of resistance to most clinically used antimalarials necessitates the discovery of new chemotypes. A phenotypic screen against asexual Plasmodium falciparum identified the 2-amino-3,4-dihydroquinazoline scaffold, previously dev...
Rational Substitution-Driven Enhancement of Anti- Mycobacterium tuberculosis Activity in a Quinoline-Isonicotinic Acid Hydrazide Hybrid [0.03%]
合理替代增强喹啉异烟酸肼杂环反结核活性
Govinda Raju Vadankula,Anushka Agarwal,Yandrapally Sriram et al.
Govinda Raju Vadankula et al.
The obstinatproblem of drug resistance in tuberculosis (TB) requires sustained efforts in the search for new drug molecules. Building on our previously developed synthetic hybrid compound, UH-NIP-16, which demonstrated anti-Mycobacterium tu...
Temporin-Derived Peptides Protect Mice against Enterohemorrhagic Escherichia coli O157:H7 Infection by Inhibiting Inflammation and Enhancing the Intestinal Epithelial Barrier [0.03%]
temporin 衍生肽通过抑制炎症和增强肠上皮屏障保护小鼠免受出血性大肠埃希杆菌O157:H7感染
Jing Chen,Ruiying Zhu,Shangjun Jiang et al.
Jing Chen et al.
Intestinal inflammation can destroy the integrity of the intestinal barrier and disrupt immune homeostasis, increasing the risks of developing fatal diseases. Enterohemorrhagic Escherichia coli (EHEC) O157:H7, a prominent pathogen primarily...
Navjot Kaur,Pragnya Roy,Mrinmoy De
Navjot Kaur
The global rise in antibiotic resistance has become a major public health concern, driving an urgent demand for new therapeutic strategies to manage infections caused by multidrug-resistant (MDR) pathogens. Nanomaterials have therefore attr...