Total Synthesis and Structure Assignment of the Relacidine Lipopeptide Antibiotics and Preparation of Analogues with Enhanced Stability [0.03%]
瑞拉西丁脂肽抗生素的全合成、结构确证及稳定化衍生物的制备
Karol Al Ayed,Denise Zamarbide Losada,Nataliia V Machushynets et al.
Karol Al Ayed et al.
The unabated rise of antibiotic resistance has raised the specter of a post-antibiotic era and underscored the importance of developing new classes of antibiotics. The relacidines are a recently discovered group of nonribosomal lipopeptide ...
Optimized Bioorthogonal Non-canonical Amino Acid Tagging to Identify Serotype-Specific Biomarkers in Verotoxigenic Escherichia coli [0.03%]
优化的生物正交非天然氨基酸标记法鉴定产毒大肠杆菌血清型特异性标志物
Miroslava Strmiskova,Jason D Josephson,Caroline Toudic et al.
Miroslava Strmiskova et al.
According to Canada's Food Report Card 2016, there are 4 million foodborne illnesses acquired each year in the nation alone. The leading causes of foodborne illness are pathogenic bacteria such as shigatoxigenic/verotoxigenic Escherichia co...
Development of Gallium(III) as an Antimicrobial Drug Targeting Pathophysiologic Iron Metabolism of Human Pathogens [0.03%]
开发镓作为针对人类病原菌病理铁代谢的抗菌药物目标元素
Zachary W Scott,Seoung-Ryoung Choi,Bradley E Britigan et al.
Zachary W Scott et al.
The treatment of infections is becoming more difficult due to emerging resistance of pathogens to existing drugs. As such, alternative druggable targets, particularly those that are essential for microbe viability and thus make it harder to...
Bovine Colostrum Exosomes Are a Promising Natural Bacteriostatic Agent against Staphylococcus aureus [0.03%]
牛初乳外泌体是一种 promising 的天然耐甲氧西林金黄色葡萄球菌抗菌剂
Gna Ahn,Woo-Ri Shin,SeonHyung Lee et al.
Gna Ahn et al.
Bioactive molecules and immune factors in the bovine colostrum (BC) are important elements of passive immunity that prevent bacterial infection. However, the mechanisms underlying the antimicrobial activity of BC are not fully understood. W...
Active Site Aromatic Residues Play a Dual Role in the Substrate Interaction and Protein Structure in Functional Dimers of CYP121A1 of Mycobacterium tuberculosis [0.03%]
结核分枝杆菌CYP121A1功能二聚体中底物结合和蛋白结构的双重作用力关系研究
Christopher S Campomizzi,Amit Kumar,Patil Pranita Uttamrao et al.
Christopher S Campomizzi et al.
The essential enzyme CYP121A1 of Mycobacterium tuberculosis forms a functional dimer, which when disrupted results in a decrease of activity and substrate specificity. The crystal structure of CYP121A1 in complex with its substrate di-cyclo...
CCCP Facilitates Aminoglycoside to Kill Late Stationary-Phase Escherichia coli by Elevating Hydroxyl Radical [0.03%]
四环素促进氨基糖苷类药物产生羟自由基杀死衰老期大肠杆菌细胞
Zhongyan Li,Ling Wu,Zhijie Huang et al.
Zhongyan Li et al.
Improving the efficacy of existing antibiotics is significant for combatting antibiotic resistance that poses a major threat to human health. Carbonyl cyanide m-chlorophenylhydrazine (CCCP), a well-known protonophore for dissipating proton ...
Optimization of Host Cell-Compatible, Antimicrobial Peptides Effective against Biofilms and Clinical Isolates of Drug-Resistant Bacteria [0.03%]
优化宿主细胞相容的抗菌肽以对抗生物膜和耐药细菌临床分离株
Jenisha Ghimire,Robert J Hart,Anabel Soldano et al.
Jenisha Ghimire et al.
Here, we describe the continued synthetic molecular evolution of a lineage of host-compatible antimicrobial peptides (AMP) intended for the treatment of wounds infected with drug-resistant, biofilm-forming bacteria. The peptides tested are ...
Serinc5 Restricts HIV Membrane Fusion by Altering Lipid Order and Heterogeneity in the Viral Membrane [0.03%]
Serinc5通过改变病毒膜中脂质的有序性和异质性来限制HIV膜融合
Amanda E Ward,Daria Sokovikova,Melvin Neal Waxham et al.
Amanda E Ward et al.
The host restriction factor, Serinc5, incorporates into budding HIV particles and inhibits their infection by an incompletely understood mechanism. We have previously reported that Serinc5 but not its paralogue, Serinc2, blocks HIV cell ent...
Antimalarial Imidazopyridines Incorporating an Intramolecular Hydrogen Bonding Motif: Medicinal Chemistry and Mechanistic Studies [0.03%]
内氢键的抗疟imidazopyridine化合物：药物化学及机制研究
Henrietta D Attram,Constance M Korkor,Dale Taylor et al.
Henrietta D Attram et al.
We previously identified a novel class of antimalarial benzimidazoles incorporating an intramolecular hydrogen bonding motif. The frontrunner of the series, analogue A, showed nanomolar activity against the chloroquine-sensitive NF54 and mu...
Urinary Glycosaminoglycans Are Associated with Recurrent UTI and Urobiome Ecology in Postmenopausal Women [0.03%]
尿糖胺聚糖与绝经后妇女反复发作的UTI和泌尿系统微生物群的关系
Michael L Neugent,Neha V Hulyalkar,Ashwani Kumar et al.
Michael L Neugent et al.
Glycosaminoglycans (GAGs) are linear, negatively charged polysaccharides composed of repeating disaccharide units of uronic acid and amino sugars. The luminal surface of the bladder epithelium is coated with a GAG layer. These urothelial GA...