Characterization of Proline-Rich Antimicrobial Peptides with SbmA Transporter-Dependent and Independent Antimicrobial Activity toward Klebsiella pneumoniae [0.03%]
具有SbmA依赖性和非依赖性抗菌活性的抗菌肽对肺炎克雷伯氏菌的特性研究
Ridhwana M Appiah,Robert L Beckman th,Christina M DeBarro et al.
Ridhwana M Appiah et al.
The rapid emergence of antibiotic resistance in Klebsiella pneumoniae is a pressing concern, largely attributed to its rapid development of antibiotic resistance. Our previous work demonstrated that Bac7 (1-35), a proline-rich antimicrobial...
Chemoproteomic Elucidation of β-Lactam Drug Targets in Mycobacterium abscessus [0.03%]
β-内酰胺药物作用靶点的化学蛋白质组学研究——以胞外分枝杆菌为例
Kaylyn L Devlin,Emily Hutchinson,Damon T Leach et al.
Kaylyn L Devlin et al.
The pathogen Mycobacterium abscessus (Mab) can cause severe and difficult-to-treat chronic lung infections. Despite the rising incidence and clinical concern of Mab infections, treatment options are limited and often ineffective. Treatment ...
Rising Stars in Infectious Diseases Research: Celebrating Our Early Career Awardees [0.03%]
感染病研究新星：庆祝获奖的早期职业科学家
Jayanta Haldar,Rebecca Moore
Jayanta Haldar
Beyond the Sand Fly and the Macrophage: A Multidimensional Redefinition of the Leishmania Life Cycle to Overcome Therapeutic Persistence [0.03%]
超越沙 fly 和巨噬细胞：利什曼原虫生活史的多维度重新定义以克服治疗持续性问题
Javier Martín-Escolano,Clotilde Marín,Anastasios D Tsaousis et al.
Javier Martín-Escolano et al.
Leishmaniasis remains a major global health challenge, hampered by an antiquated therapeutic arsenal compromised by toxicity, resistance, and an inability to achieve a sterile cure. The high attrition rate in drug and vaccine development st...
Tolfenpyrad Modulates Antibiotic Activity on Francisella novicida and Synergizes with Electron Transport Chain Inhibitors [0.03%]
(tol芬吡隆调节托勒密素对弗朗西斯菌的抗菌活性并与电子传递链抑制剂协同作用)
Chloe Marmarosh Van Horn,Nimra Khalid,Henry S Heine et al.
Chloe Marmarosh Van Horn et al.
Francisella tularensis is a highly virulent intracellular pathogen for which treatment options remain limited and vulnerable to resistance development. Tolfenpyrad, a pesticide with selective antibacterial activity against Francisella speci...
Targeting G3BP1-Mediated Stress Granules to Suppress SARS-CoV-2 Replication [0.03%]
靶向G3BP1介导的应激颗粒以抑制SARS-CoV-2复制
Rukayat Aromokeye,Lisha Kuang,Martha Ackerman-Berrier et al.
Rukayat Aromokeye et al.
Stress granules (SGs) are cytoplasmic, membraneless assemblies of proteins and RNAs that transiently form in response to cellular stress. Dysregulation of SGs has been associated with cancer, neurodegeneration, and viral infection. GTPase-a...
Exploring the Role of Pseudomonas aeruginosa Elastase in Lung Epithelial Barrier Dysfunction: Advancing toward Antivirulence Therapies [0.03%]
铜绿假单胞菌弹性蛋白酶在肺上皮屏障功能障碍中的作用及抗毒力治疗研究进展
Roya Shafiei,Alaa Alhayek,Lukas Hiller et al.
Roya Shafiei et al.
Pseudomonas aeruginosa, a major cause of pulmonary infections, poses significant clinical challenges due to its virulence and rising antimicrobial resistance. We investigated the role of LasB, a key virulence factor and elastase of P. aerug...
Nitric Oxide-Releasing Therapeutics for Treating Bacterial Infections: Anatomical Targeting and Therapeutic Design [0.03%]
用于治疗细菌感染的释放一氧化氮药物：解剖定位与治疗设计
Courtney R Johnson,Tsian D Ramrattan,Mikaylin E Nogler et al.
Courtney R Johnson et al.
Targeted therapeutic delivery for treating bacterial infections remains underutilized in most pharmaceutical interventions. Existing therapeutics (i.e., antibiotics) are often systematically administered despite the presence of localized in...
MicroRNA-146a-5p Negatively Regulates Inflammation via the Dectin-1/Syk/NF-κB Signaling Pathway in Aspergillus fumigatus Keratitis [0.03%]
microRNA-146a-5p通过Dectin-1/Syk/NF-κB信号通路在烟曲霉角膜炎中负向调节炎症反应
Xiangzhi Liu,Xue Tian,Jing Lin et al.
Xiangzhi Liu et al.
This study investigated the role of microRNA-146a-5p (miR-146a-5p) in the pathogenesis of fungal keratitis (FK). In a murine model of Aspergillus fumigatus (A. fumigatus) infection, miR-146a-5p was significantly upregulated. Functionally, o...
SARS-CoV-2 Antivirals Identified from Small Molecule Modulators of Programmed -1 Ribosomal Frameshifting [0.03%]
通过程序化-1核糖体 frameshifting调节剂筛选SARS-CoV-2 抗病毒药物
Emily G Swanson Hay,Madison M Maille,Martina Zafferani et al.
Emily G Swanson Hay et al.
Remaining SARS-CoV-2 vulnerable populations and the threat of viral resistance to existing immunity and COVID-19 vaccines highlight the need to expand treatment options. While the number of SARS-CoV-2 viral proteins is limited for therapeut...