Cytochrome bc1 Catalytic Subunit Rip1 Modulates Antifungal Tolerance in Candida auris [0.03%]
白念珠菌细胞色素bc1催化亚基RIP1调控抗真菌耐受性
Trinh Phan-Canh,Michaela Lackner,Manju Chauhan et al.
Trinh Phan-Canh et al.
Candida auris is an emerging fungal pathogen causing invasive infections in immunocompromised patients, with mortality rates reaching up to 60%. Pronounced drug resistance makes treatment failure common, and so does antifungal tolerance, a ...
Anti-RBD Single-Chain Variable Fragments Library (scFv Library) Generation toward the Development of a Diagnostic Platform for SARS-CoV-2 [0.03%]
针对开发SARS-CoV-2诊断平台的抗RBD单链可变片段库（scFv文库）的构建
Mohd Shoeb Alam,Saurabh Sharma,Romisa Razvi et al.
Mohd Shoeb Alam et al.
The continued emergence of SARS-CoV-2 variants worldwide underscores the need for effective measures to combat the current and future outbreaks. The receptor-binding domain (RBD) of the spike glycoprotein plays a critical role in viral entr...
Targeting Picornavirus Nonstructural 2C Protein: Structure, Function, and Antiviral Discovery [0.03%]
针对小RNA病毒非结构型2C蛋白：结构、功能及抗病毒物质筛选发现进展
Kan Li,Guangjin Fan,Wenyi Zhang et al.
Kan Li et al.
Picornaviruses cause substantial human and veterinary disease, yet direct-acting antivirals remain limited. The nonstructural protein 2C is among the most conserved picornaviral proteins and has ATPase and helicase-like activities. 2C is in...
Label-Free Liquid Crystal-Based Dielectric Genosensor for Infectious Bacterial Detection [0.03%]
一种用于检测致病细菌的无标签液晶介质基因传感器
Rohit Kumar,Gajjala Sumana,Sudesh Yadav et al.
Rohit Kumar et al.
A dielectric liquid crystal (LC)-based genosensor was developed for the detection of the bacterium, Neisseria gonorrhoeae, a sexually transmitted pathogen. The LC-dielectric sensing platform was fabricated by biomolecular immobilization of ...
Biophysical Elucidation of the Distinct Roles the Nipah Virus Attachment and Fusion Glycoproteins Play in the Entry Process [0.03%]
尼帕病毒附着和融合糖蛋白在进入过程中所起的不同作用的生物物理阐释
Sreetama Pal,Hector C Aguilar,Susan Daniel
Sreetama Pal
Nipah virus (NiV), a World Health Organization priority pathogen, is a lethal enveloped RNA virus within the Paramyxoviridae family. NiV attachment G and fusion F glycoproteins execute viral-cell or cell-cell membrane fusion during viral en...
Lyophilized LAMP Assay Combined with Lateral Flow Biosensor for Cold-Chain-Free Detection of Mycobacterium tuberculosis [0.03%]
结合侧向流动生物传感器的冷冻干燥LAMP检测试剂盒用于检测结核分支杆菌无需冷链管理
Jutturong Ckumdee,Somchai Santiwatanakul,Nakarin Vutipow et al.
Jutturong Ckumdee et al.
To decentralize tuberculosis surveillance in resource-limited and tropical regions, a rapid, robust, and cold-chain-independent near-point-of-care biosensor is urgently required to overcome the instability of conventional liquid-formulation...
Multipronged Cell Wall-Targeting Converts Ineffective Antibiotics into a Potent Regimen against Mycobacterium abscessus [0.03%]
多管齐下的细胞壁靶向策略可将无效抗生素转化为高效的抵抗嗜血毛孢子菌的治疗方案
Carmen J E Pee,May Delos Santos,Kevin Pethe
Carmen J E Pee
Mycobacterium abscessus is an intrinsically drug-resistant pathogen responsible for chronic lung infections that are notoriously difficult to cure. Its complex, multilayered cell wall limits drug penetration and underlies the poor efficacy ...
Development of Fluorogenic Probes to Detect Glycan-Degrading Enzymes in Bacteria [0.03%]
用于检测细菌中糖链降解酶的荧光探针的发展
Esteban Tarazona Guzman,Ankita Paul,Karen D Moulton et al.
Esteban Tarazona Guzman et al.
Bacterial fitness and survival depend on the biosynthesis and maintenance of cell-envelope glycans. Bacterial glycans are composed of over 700 monosaccharides, and their construction, tailoring, recycling, and degradation require the choreo...
Random Forest Modeling to Predict Small Molecule Accumulation in Gram-Negative Bacteria [0.03%]
随机森林建模预测小分子在革兰氏阴性菌中的积累
Blake R Levy,Paul J Hergenrother
Blake R Levy
Despite extensive efforts over the past ∼60 years to discover new classes of Gram-negative-active antibiotics, the development pipeline remains relatively dry. These failures can be largely ascribed to the complexity of the Gram-negative m...
Structure-Activity Analysis of the Competence Stimulating Peptide-1 in Streptococcus mitis [0.03%]
变链菌素肽-1的构效关系分析研究
Morgan M Yeager,April K Murray,Ripon C Bhowmic et al.
Morgan M Yeager et al.
Antibiotic-resistant bacteria are one of the greatest challenges in modern medicine, as multidrug-resistant strains continue to outpace traditional antibiotic development. Unlike conventional antibiotics that promote resistance through sele...