Kevin B Laupland,Daniel Dagasso,Yoav Keynan
Kevin B Laupland
Narrow spectrum, broad utility: Reassessing cephalexin and cefazolin beyond cellulitis [0.03%]
窄谱广用途：超出蜂窝织炎评估头孢氨苄和头孢唑林的作用
Carsten Krueger,Waleed Alqurashi,Eric Eckbo et al.
Carsten Krueger et al.
Can switching to doravirine/lamivudine/tenofovir DF halt or reverse INSTI-associated weight gain? [0.03%]
换用多拉韦林/拉米夫定/富马酸替诺福韦酯能阻止或逆转整合酶抑制剂相关的体重增加吗？
Alice Tseng,Mona Loutfy,Lianne Thai et al.
Alice Tseng et al.
Background: In randomized trials, doravirine (DOR) appears relatively weight-neutral, while tenofovir DF (TDF) may be weight-suppressive. Here we designed a prospective, observational pilot study to assess the impact of s...
Salmonella Typhi mimicking Pott's disease: A case report and review of the literature [0.03%]
肠热病型沙门氏菌导致的Pott病：病例报告及文献回顾
Nikesh Pandey,Philip W Lam
Nikesh Pandey
Background: Infectious spondylodiscitis, an infection that involves the intervertebral disc and adjacent vertebral body, often manifests as back pain, fever, and malaise. Although Staphylococcus aureus is the most commonl...
Emergence of seasonal influenza A(H3N2) variants with immune escape potential warrants enhanced molecular and epidemiological surveillance for the 2025-2026 season [0.03%]
具有免疫逃逸潜力的季节性甲型流感H3N2亚系出现，敦促在2025-2026年加强分子和流行病学监测
Suzana Sabaiduc,Samantha E Kaweski,Lea Separovic et al.
Suzana Sabaiduc et al.
Background: All of the major antigenic changes in influenza A(H3N2) viruses since 1968 have involved mutations at just nine amino acid positions, called cluster transition sites, surrounding the receptor binding region of...
Can emulated trials in antimicrobial therapy replace randomized trials? [0.03%]
抗菌药物治疗中的模拟试验能否替代随机试验？
Thomas C Scheier,Dominik Mertz,John W Eikelboom
Thomas C Scheier
Extended-duration dexamethasone for the treatment of hospitalized COVID-19 patients in Canada: A randomized clinical trial [0.03%]
加拿大住院COVID-19患者的延长疗程地塞米松治疗：一项随机临床试验
Liran Shechtman,Srinivas Murthy,Alain Tremblay et al.
Liran Shechtman et al.
The optimal duration of corticosteroid therapy in hospitalized COVID-19 patients remains uncertain. While a 10-day course of dexamethasone reduces mortality, the benefit of extending treatment in patients who continue to require oxygen is u...
Using a paper-based checklist for promoting increased access to long-acting injectable cabotegravir/rilpivirine among people living with HIV in Toronto: Lessons learned from a quality improvement initiative [0.03%]
多部门合作使用纸质核查表促进HIV感染者长效注射型卡博特拉韦/利匹韦林的可及性：来自质改项目的经验教训
Myo Min Oo,Archchana Arulananthan,Ashan Wijesinghe et al.
Myo Min Oo et al.
Long-acting injectable (LAI) cabotegravir/rilpivirine (CAB/RPV) offers a promising alternative to daily oral antiretroviral therapy for individuals with HIV, potentially addressing adherence challenges and pill fatigue. However, its impleme...
Babak Pourmomenarabi,Leigh J Sowerby,Keith Kwan et al.
Babak Pourmomenarabi et al.
Background: Rhinoscleroma is a chronic granulomatous infectious disease of the respiratory mucosa, endemic in some countries of Central America, Southeast Asia, and parts of Africa, but rare in North America. ...
Using routine asymptomatic Clostridioides difficile testing to identify patients at high risk of developing C. difficile infection during hematopoietic cell transplantation [0.03%]
利用常规的无症状艰难梭菌检测识别在造血细胞移植过程中发生艰难梭菌感染高风险的患者
Nicole Janusz,Leanne Mortimer,Tamara Leite et al.
Nicole Janusz et al.
Background: Colonization with enteropathogens such as Clostridioides difficile has been linked to clinical infection with these same organisms. C. difficile infection (CDI) is associated with increased morbidity and morta...