Invasive bilateral breast cancer and high grade serous ovarian cancer with BRCA1-germline mutation and brainstem metastasis under PARP inhibitors [0.03%]
携带BRCA1基因突变的侵袭性双侧乳腺癌和高级别浆液性卵巢癌及PARP抑制剂下的脑干转移
Mihaela Mărioara Zahari,Angelica Rita Chiorean,Maria Magdalena Duma et al.
Mihaela Mărioara Zahari et al.
For breast cancer patients, BRCA gene mutations are predictive of a good response to chemotherapy, but are hampered by a high risk of bilateral and synchronous or metachronous ovarian cancer. Novel therapies such as PARP-inhibitors have pro...
Raluca Balan,Adriana Grigoraş,Diana Popovici et al.
Raluca Balan et al.
Psoriasiform dermatoses represent a wide spectrum of inflammatory conditions, with several major forms represented by psoriasis, as the prototype of this category, followed by pustular psoriasis, Reiter's syndrome, pityriasis rubra pilaris,...
Gabriela Maria Aniţei,Nicolae Şerban Ioanid,Geanina Bandol et al.
Gabriela Maria Aniţei et al.
Porocarcinoma is a rare tumor of the eccrine sweat glands that usually disseminates to the regional lymph nodes, but it can also develop distant metastasis. Case presentation: We report the case of a 67 year-old female patient who underwent...
Luís Rodrigues,Glória Nunes da Silva,António Pais de Lacerda
Luís Rodrigues
Felty's syndrome (rheumatoid arthritis with neutropenia and splenomegaly) is a rare condition with poor long-term prognosis, mainly as a result of severe infection risk. An effective treatment strategy has not been developed so far and curr...
From eosinophilic esophagitis to esophagus perforation: clinical management strategies [0.03%]
从嗜酸性食管炎到食管穿孔的临床管理策略
Tabita Timeea Scutaru,Péter Kupcsulik,Péter Sahin et al.
Tabita Timeea Scutaru et al.
Introduction: Eosinophilic esophagitis is a chronic, antigen-mediated inflammation of the esophagus. The disease is most common at young ages, with a male to female ratio of 3:1. Eosinophilic granulocyte infiltration indu...
Celiac disease: uncommon, oligosymptomatic course of illness, with profound hypoalbuminemia in an adult patient [0.03%]
成人乳糜泻患者出现显著低白蛋白血症的不常见寡症状病程
Łukasz Lis,Andrzej Konieczny,Patryk Jerzak et al.
Łukasz Lis et al.
Celiac disease (CD) is an immune-mediated disease, caused by gluten, occurring in people with genetic predisposition. The course of the disease can vary and includes both intestinal and extra-intestinal manifestations. Many patients are und...
Cerebral vein thrombosis associated with MTHFR A1289C mutation gene in a young postpartum woman [0.03%]
年轻产妇中与MTHFR A1289C突变基因相关的脑静脉血栓形成
Alexandru Bostan,Laura Cătălina Țăpoi,Marian Nicolae Barcan et al.
Alexandru Bostan et al.
Cerebral venous thrombosis is a rare cerebrovascular disease that accounts for approximately 1% of strokes, with an incidence of 3-4 cases / million inhabitants per year, with a significant mortality rate of 10-13%. Pregnancy and puerperal ...
Underlying coeliac disease in a case of cerebellar ataxia with unknown etiology [0.03%]
小脑性共济失调病因不明病例中的潜在乳糜泻病
Deepak Jain,Gourab Bhaduri,Kajaree Giri et al.
Deepak Jain et al.
Celiac disease is an immune mediated enteropathy in susceptible individuals as a response to gluten containing diets based on wheat, oat, rye and maize. It clinically presents with malabsorption syndrome along with a myriad of extraintestin...
Cephalic undifferentiated carcinoma with osteoclast-like giant cells arising from the main pancreatic duct: case report and literature review [0.03%]
主胰管起源的以巨细胞为主要成分的未分化癌一例及文献复习
Andreea Rusu,Simona Eliza Giuşcă,Delia Gabriela Ciobanu Apostol et al.
Andreea Rusu et al.
Undifferentiated carcinoma with osteoclast-like giant cell (UCOGC) is a ductal carcinoma variant with a recently reported more protracted survival and pathognomonic histology comprising two cell populations: the mononuclear tumoral cells an...
Lower lateral crural turnover flap combined with alar batten graft for the long-term result of the treatment of alar convexities [0.03%]
治疗鼻翼凸起的长期效果结合鼻翼衬瓣的下外侧脚翻转瓣和鼻翼支撑移植物
Philippine Merlin,Amanda Fanous,Jean-Paul Marie et al.
Philippine Merlin et al.
Introduction: Concave lower lateral cartilages not only cause an esthetic defect but can also lead to external nasal valve insufficiency. The objective of this article is to analyze the combination of two well-known surgi...