What to do when nothing else is left to be done - metastatic non-HPV vulvar squamous cell carcinoma with multiple lines of chemotherapy [0.03%]
当别无所获时我们还能做些什么？- 多线化疗后的复发性非HPV外阴鳞癌的治疗困境及思考
Mihaela Mărioara Stana,Sandra Deac,Călin Cainap et al.
Mihaela Mărioara Stana et al.
Recurrent vulvar squamous cell carcinoma with multiple site metastases is a rare entity - (up to 14.2% of the total number of recurrences), with a poor prognosis (only 15% of the patients alive at 5 years). Due to its "hard to find" charact...
Brandon W Knopp,Parvathi Perumareddi
Brandon W Knopp
Type 1 and type 2 diabetes have been described historically as occurring in distinct patient populations; however, atypical demographics are becoming more frequent as the prevalence of diabetes increases, crossing boundaries of ages. Some o...
Total occlusion of abdominal aorta: still a deadly event in the very elderly [0.03%]
腹主动脉完全闭塞仍是极高龄患者致命的事件
Gonçalo José Pereira Carneiro,Carla Martins
Gonçalo José Pereira Carneiro
Total occlusion of the abdominal aorta is an uncommon but potentially devastating event. Clinical symptoms are usually sudden and may vary depending on the level of the aortic occlusion. Associated morbidity and mortality remain substantial...
Budumuri Gautam V Kumar,Purna Ch Sethy,Rohit Gupta
Budumuri Gautam V Kumar
A 24-year-old male without previously known comorbidities presented with progressive jaundice and hepatomegaly. Autoimmune serology and liver biopsy revealed features of autoimmune hepatitis. A treatment by oral prednisolone and azathioprin...
Katherine M Cooper,Bradley Switzer
Katherine M Cooper
Immune thrombocytopenic purpura (ITP) is a rare hematologic condition through to affect 3.3 in 100,000 adults per year in the United States. Many cases of immune thrombocytopenia are diagnosed incidentally with laboratory tests that reveal ...
Brandon W Knopp,Bailey Pierce,Vishnu Muppala et al.
Brandon W Knopp et al.
Brugada syndrome is a rare genetic disorder of the cardiac sodium channels associated with an increased risk of sudden cardiac death. It is characterized by an electrocardiogram (EKG) showing a right bundle branch block with an elevation in...
Sangay Tshering,Namkha Dorji,Sonam Youden et al.
Sangay Tshering et al.
Fetal growth restriction associated with continued maternal sirolimus therapy in pregnancy has not been reported. We hereby present a case of maternal sirolimus therapy resulting in fetal growth restriction and propose a multi-hit model. Th...
PD-L1 testing and immunotherapy selection - early laboratory experience and its potential role in head and neck cancer management [0.03%]
PD-L1检测及其在头颈部癌症管理中选择免疫治疗的潜在作用——早期实验室经验
Andrei Bancu,Richard Cowan,Anshuman Chaturvedi
Andrei Bancu
Anti-programmed cell death protein-1 (PD-1) therapy has been relatively recently approved in a defined context by NICE in adults in the management of recurrent and metastatic head and neck squamous cell carcinomas (HNSCC). In this context, ...
Morphology and one immunohistochemical marker are enough for diagnosis of primary thyroid angiosarcoma [0.03%]
甲状腺血管肉瘤的诊断形态学和一个免疫组化标记就足够了
Ion Negură,Minerva Codruţa Bădescu,Ciprian Rezuş et al.
Ion Negură et al.
Primary thyroid angiosarcoma is a very rare and extremely aggressive mesenchymal malignant neoplasm showing morphological and immunophenotypic evidence of endothelial cell differentiation. Early diagnosis of this tumor along with radical th...
Failure of non-vitamin K antagonist oral anticoagulants in preventing stroke in elderly patient: a case report of multiple strokes on standard of care treatment for atrial fibrillation [0.03%]
非维生素K拮抗剂口服抗凝剂在预防老年患者中风时的失败：在接受房颤标准治疗过程中发生多次中风的一个病例报告
Frank Bernard Ebai,Azam Mohiuddin
Frank Bernard Ebai
Atrial fibrillation (AF) is the most common type of treated heart arrhythmia. Generally, the treatment goals for atrial fibrillation are to reset the rhythm or control the rate and prevent the development and subsequent embolization of atri...