SAR110894, a potent histamine H3-receptor antagonist, displays disease-modifying activity in a transgenic mouse model of tauopathy [0.03%]
SAR110894，一种有效的组胺H3受体拮抗剂，在tau病转基因小鼠模型中显示出延缓疾病进展的作用
Philippe Delay-Goyet,Véronique Blanchard,Nathalie Schussler et al.
Philippe Delay-Goyet et al.
Introduction: Tau hyperphosphorylation and neurofibrillary tangles are histopathologic hallmarks of tauopathies. Histamine H3-receptor antagonists have been proposed to reduce tau hyperphosphorylation in preclinical model...
Measuring informed consent capacity in an Alzheimer's disease clinical trial [0.03%]
阿尔茨海默病临床试验中的知情同意能力评估
Peter D Guarino,Julia E Vertrees,Sanjay Asthana et al.
Peter D Guarino et al.
Introduction: Accurately and efficiently determining a participant's capacity to consent to research is critically important to protect the rights of patients with Alzheimer's disease (AD). ...
A multicenter, randomized, placebo-controlled trial for cilostazol in patients with mild cognitive impairment: The COMCID study protocol [0.03%]
西洛他唑治疗轻度认知障碍的多中心随机双盲安慰剂对照研究（COMCID 研究）方案
Satoshi Saito,Shinsuke Kojima,Naoya Oishi et al.
Satoshi Saito et al.
Introduction: There are currently no effective treatments preventing conversion from mild cognitive impairment (MCI) to Alzheimer's disease. Cilostazol is a selective type-3 phosphodiesterase inhibitor that ameliorates ac...
Mnemonic strategy training of the elderly at risk for dementia enhances integration of information processing via cross-frequency coupling [0.03%]
针对有痴呆风险的老年人进行助记策略训练可增强跨频率耦合信息加工整合能力
Stavros I Dimitriadis,Ioannis Tarnanas,Mark Wiederhold et al.
Stavros I Dimitriadis et al.
Introduction: We sought to identify whether intensive 10-week mobile health mnemonic strategy training (MST) could shift the resting-state brain network more toward cortical-level integration, which has recently been prov...
Design of the NL-ENIGMA study: Exploring the effect of Souvenaid on cerebral glucose metabolism in early Alzheimer's disease [0.03%]
NL-ENIGMA研究设计：营养干预对轻度阿尔茨海默病患者脑葡萄糖代谢的影响探索
Nienke M E Scheltens,Ingrid S Kuyper,Ronald Boellaard et al.
Nienke M E Scheltens et al.
Introduction: Alzheimer's disease is associated with early synaptic loss. Specific nutrients are known to be rate limiting for synapse formation. Studies have shown that administering specific nutrients may improve memory...
Jeffrey Cummings,Travis Morstorf,Garam Lee
Jeffrey Cummings
Background: Alzheimer's disease (AD) is growing in frequency and new therapies are urgently needed. Methods: We assessed clinicaltrials...
Profiling the dynamics of CSF and plasma Aβ reduction after treatment with JNJ-54861911, a potent oral BACE inhibitor [0.03%]
JNJ-54861911的I期临床研究：一种高效的口服BACE抑制剂对脑脊液和血浆中Aβ水平降低的动力学影响
Maarten Timmers,Bianca Van Broeck,Steven Ramael et al.
Maarten Timmers et al.
Objectives: Safety, tolerability, pharmacokinetics, and pharmacodynamics of a novel β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, JNJ-54861911, were assessed after single and multiple dosing in he...
Dirk M Hermann
Dirk M Hermann
Vitamin E has recently been suggested to slow down the progression of Alzheimer's disease. Current evidence is based on three studies in patients with Alzheimer's disease and one study in patients with mild cognitive impairment which all to...
Quantile regression to characterize solanezumab effects in Alzheimer's disease trials [0.03%]
分位数回归在阿尔茨海默病临床试验中刻画Solanezumab的作用效应
Yun-Fei Chen,Xiwen Ma,Karen Sundell et al.
Yun-Fei Chen et al.
Introduction: In two solanezumab trials for mild-to-moderate Alzheimer's disease (AD) dementia, 27% of patients had biomarker confirmation of amyloid status. Of these, approximately 25% of mild patients and approximately ...
Vitamin E family: Role in the pathogenesis and treatment of Alzheimer's disease [0.03%]
维生素E家族在阿尔茨海默病发病机制和治疗中的作用
Virginia Boccardi,Marta Baroni,Francesca Mangialasche et al.
Virginia Boccardi et al.
Introduction: Vitamin E family, composed by tocopherols and tocotrienols, is a group of compounds with neuroprotective properties. The exact role in the pathogenesis and the benefit of vitamin E as treatment for Alzheimer...