Effect of physical exercise on markers of neuronal dysfunction in cerebrospinal fluid in patients with Alzheimer's disease [0.03%]
体育锻炼对阿尔茨海默病患者脑脊液神经元功能异常标志物的影响
Camilla Steen Jensen,Erik Portelius,Peter Høgh et al.
Camilla Steen Jensen et al.
Introduction: Physical exercise has gained increasing focus as a potential mean to maintain cognitive function in patients with Alzheimer's disease (AD). Alongside the markers of specific AD pathology (amyloid β and tau)...
Accelerating drug development for Alzheimer's disease through the use of data standards [0.03%]
通过使用数据标准加速阿尔茨海默病的药物研发
Jon Neville,Steve Kopko,Klaus Romero et al.
Jon Neville et al.
Introduction: The exceedingly high rate of failed trials in Alzheimer's disease (AD) calls for immediate attention to improve efficiencies and learning from past, ongoing, and future trials. Accurate, highly rigorous stan...
UB-311, a novel UBITh® amyloid β peptide vaccine for mild Alzheimer's disease [0.03%]
一种新型的UBIBTh淀粉样蛋白β肽疫苗UB-311用于轻度阿尔茨海默病
Chang Yi Wang,Pei-Ning Wang,Ming-Jang Chiu et al.
Chang Yi Wang et al.
Introduction: A novel amyloid β (Aβ) synthetic peptide vaccine (UB-311) has been evaluated in a first-in-human trial with patients of mild-to-moderate Alzheimer's disease. We describe translational research covering vac...
Inferior parietal transcranial direct current stimulation with training improves cognition in anomic Alzheimer's disease and frontotemporal dementia [0.03%]
经颅直流刺激配合训练改善词遗忘型阿尔茨海默病和额颞叶痴呆患者的认知功能
Carlos Roncero,Heike Kniefel,Erik Service et al.
Carlos Roncero et al.
Introduction: We evaluated whether transcranial direct current stimulation (tDCS) can improve picture-naming abilities in subjects with anomic Alzheimer or frontotemporal dementias. ...
Differential medial temporal lobe morphometric predictors of item- and relational-encoded memories in healthy individuals and in individuals with mild cognitive impairment and Alzheimer's disease [0.03%]
健康人和轻度认知障碍及阿尔茨海默病患者中以项目和关系编码记忆的侧颞叶形态计量预测指标不同
Jesus J Gomar,J Daniel Ragland,Aziz M Uluğ et al.
Jesus J Gomar et al.
Introduction: Episodic memory processes are supported by different subregions of the medial temporal lobe (MTL). In contrast to a unitary model of memory recognition supported solely by the hippocampus, a current model su...
Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia [0.03%]
社会关系、血清脑源性神经营养因子与中风和痴呆风险之间的关联分析
Joel Salinas,Alexa Beiser,Jayandra J Himali et al.
Joel Salinas et al.
Introduction: Mechanisms underlying social determinants of stroke and dementia are unclear and brain-derived neurotrophic factor (BDNF) may contribute as a molecular link. ...
Meysam Asgari,Jeffrey Kaye,Hiroko Dodge
Meysam Asgari
Introduction: Trials in Alzheimer's disease are increasingly focusing on prevention in asymptomatic individuals. We hypothesized that indicators of mild cognitive impairment (MCI) may be present in the content of spoken l...
Zfra restores memory deficits in Alzheimer's disease triple-transgenic mice by blocking aggregation of TRAPPC6AΔ, SH3GLB2, tau, and amyloid β, and inflammatory NF-κB activation [0.03%]
左归丸通过抑制TRAPPC6AΔ、SH3GLB2、tau和淀粉样蛋白β聚集及NF-κB炎症信号激活修复三转基因阿尔茨海默病小鼠学习记忆缺损
Ming-Hui Lee,Yao-Hsiang Shih,Sing-Ru Lin et al.
Ming-Hui Lee et al.
Introduction: Zinc finger-like protein that regulates apoptosis (Zfra) is a naturally occurring 31-amino-acid protein. Synthetic peptides Zfra1-31 and Zfra4-10 are known to effectively block the growth of many types of ca...
Targeting butyrylcholinesterase for preclinical single photon emission computed tomography (SPECT) imaging of Alzheimer's disease [0.03%]
乙酰胆碱酯酶靶向的单光子发射计算机断层扫描(SPECT)成像用于阿尔茨海默病的临床前研究
Drew R DeBay,George A Reid,Ian R Pottie et al.
Drew R DeBay et al.
Introduction: Diagnosis of Alzheimer's disease (AD) in vivo, by molecular imaging of amyloid or tau, is constrained because similar changes can be found in brains of cognitively normal individuals. Butyrylcholinesterase (...
Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment [0.03%]
有血管性认知障碍患者有氧运动对脑血流影响的ExCersion-VCI研究设计
Anna E Leeuwis,Astrid M Hooghiemstra,Raquel Amier et al.
Anna E Leeuwis et al.
There is evidence for a beneficial effect of aerobic exercise on cognition, but underlying mechanisms are unclear. In this study, we test the hypothesis that aerobic exercise increases cerebral blood flow (CBF) in patients with vascular cog...