Study protocol of the Intense Physical Activity and Cognition study: The effect of high-intensity exercise training on cognitive function in older adults [0.03%]
高强度锻炼对老年人认知功能影响的IPAQ研究方案
Belinda M Brown,Stephanie R Rainey-Smith,Natalie Castalanelli et al.
Belinda M Brown et al.
Introduction: Inconsistent results from previous studies of exercise and cognitive function suggest that rigorously designed randomized controlled trials are urgently needed. Here, we describe the design of the Intense Ph...
Impact of programs to reduce antipsychotic and anticholinergic use in nursing homes [0.03%]
护理院减少使用抗精神病药物和抗胆碱药物项目的实施效果
Ryan M Carnahan,Grant D Brown,Elena M Letuchy et al.
Ryan M Carnahan et al.
Introduction: Antipsychotics are used for managing behavioral and psychological symptoms of dementia (BPSD) but have risks. Anticholinergics can worsen outcomes in dementia. The Improving Antipsychotic Appropriateness in ...
Biomathematical screening of amyloid radiotracers with clinical usefulness index [0.03%]
具有临床实用性指数的淀粉样放射示踪剂的生物数学筛选
Ying-Hwey Nai,Miho Shidahara,Chie Seki et al.
Ying-Hwey Nai et al.
Introduction: To facilitate radiotracers' development, a screening methodology using a biomathematical model and clinical usefulness index (CUI) was proposed to evaluate radiotracers' diagnostic capabilities. ...
Concise informed consent to increase data and biospecimen access may accelerate innovative Alzheimer's disease treatments [0.03%]
简明的知情同意以增加数据和生物样本的获取可能加速创新的阿尔茨海默病治疗
Ann M Hake,Penny A Dacks,Stephen P Arnerić;CAMD ICF working group
Ann M Hake
Introduction: Informed consent forms that restrict the distribution of data and samples have been an impediment to advancing Alzheimer's disease (AD) understandings and treatments. The Coalition Against Major Disease publ...
Potential implications of practice effects in Alzheimer's disease prevention trials [0.03%]
阿尔茨海默病预防研究中练习效应的潜在影响
Diane M Jacobs,M Colin Ard,David P Salmon et al.
Diane M Jacobs et al.
Introduction: Practice effects (PEs) present a potential confound in clinical trials with cognitive outcomes. A single-blind placebo run-in design, with repeated cognitive outcome assessments before randomization to treat...
Characterization of APOE and TOMM40 allele frequencies in the Japanese population [0.03%]
APOE和TOMM40等位基因在日本人群中的分布特点
Akira Nishimura,Hidenori Nonomura,Shingo Tanaka et al.
Akira Nishimura et al.
Introduction: Dementia is one of the major health threats to our aging society, and Alzheimer's disease (AD) is the leading cause. In Japan, ∼15% of the elderly population has dementia. The apolipoprotein E (APOE) genoty...
The effect of diagnostic criteria on outcome measures in preclinical and prodromal Alzheimer's disease: Implications for trial design [0.03%]
诊断标准对临床前和前驱期阿尔茨海默病结局测量的影响：对试验设计的意义
Daniela Bertens,Betty M Tijms,Lisa Vermunt et al.
Daniela Bertens et al.
Introduction: We investigated the influence of different inclusion criteria for preclinical and prodromal Alzheimer's disease (AD) on changes in biomarkers and cognitive markers and on trial sample size estimates. ...
An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations [0.03%]
一项8周、开放标记、剂量寻找尼莫地平治疗GRN基因突变导致的プログラニン不足症的研究
Sharon J Sha,Zachary A Miller,Sang-Won Min et al.
Sharon J Sha et al.
Introduction: Frontotemporal lobar degeneration-causing mutations in the progranulin (GRN) gene reduce progranulin protein (PGRN) levels, suggesting that restoring PGRN in mutation carriers may be therapeutic. Nimodipine,...
A general neurologist's perspective on the urgent need to apply resilience thinking to the prevention and treatment of Alzheimer's disease [0.03%]
神经学家视角：急切需要应用抗逆力思维以进行预防和治疗阿尔茨海默病
Grazyna Pomorska,Judith K Ockene
Grazyna Pomorska
The goal of this article was to look at the problem of Alzheimer's disease (AD) through the lens of a socioecological resilience-thinking framework to help expand our view of the prevention and treatment of AD. This serious and complex publ...
Gamma rhythm low field magnetic stimulation alleviates neuropathologic changes and rescues memory and cognitive impairments in a mouse model of Alzheimer's disease [0.03%]
阿尔茨海默病小鼠模型中伽玛节律低场磁刺激缓解神经病理变化并改善认知和记忆损伤
Junli Zhen,Yanjing Qian,Xiechuan Weng et al.
Junli Zhen et al.
Introduction: The abnormal amyloid β (Aβ) accumulation and Aβ-related neural network dysfunction are considered central to the pathogenesis of Alzheimer's disease (AD) at the early stage. Deep-brain reachable low field...