Integrating sex and gender into neurodegeneration research: A six-component strategy [0.03%]
在神经退行性疾病研究中整合性别和性别的六个组成部分的战略
Mary C Tierney,Ashley F Curtis,Howard Chertkow et al.
Mary C Tierney et al.
Introduction: Despite important sex differences, there remains a paucity of studies examining sex and gender differences in neurodegeneration. The Canadian Consortium on Neurodegeneration in Aging (CCNA), a national netwo...
James P Higham
James P Higham
Richard C Mohs,Nigel H Greig
Richard C Mohs
This article provides a brief overview of the processes of drug discovery and development. Our aim is to help scientists whose research may be relevant to drug discovery and/or development to frame their research report in a way that approp...
Computerized cognitive training for older diabetic adults at risk of dementia: Study protocol for a randomized controlled trial [0.03%]
计算机认知训练对老年糖尿病患者痴呆高风险人群的干预试验方案：一项随机对照试验研究方案
Rachel Bloom,Michal Schnaider-Beeri,Ramit Ravona-Springer et al.
Rachel Bloom et al.
Introduction: Older adults with type 2 diabetes are at high risk of cognitive decline and dementia and form an important target group for dementia risk reduction studies. Despite evidence that computerized cognitive train...
A randomized, exploratory molecular imaging study targeting amyloid β with a novel 8-OH quinoline in Alzheimer's disease: The PBT2-204 IMAGINE study [0.03%]
一项针对阿尔茨海默病患者的新一代8-羟基喹啉PBT2的脑部成像研究：PBT2-204 IMAGINE 研究
Victor L Villemagne,Christopher C Rowe,Kevin J Barnham et al.
Victor L Villemagne et al.
Introduction: We are developing a second generation 8-OH quinoline (2-(dimethylamino) methyl-5, 7-dichloro-8-hydroxyquinoline [PBT2, Prana Biotechnology]) for targeting amyloid β (Aβ) in Alzheimer's disease (AD). In an ...
Protective effect of antirheumatic drugs on dementia in rheumatoid arthritis patients [0.03%]
抗风湿药物对类风湿关节炎患者痴呆的保护作用
Andy Judge,Cesar Garriga,Nigel K Arden et al.
Andy Judge et al.
Introduction: Rheumatoid arthritis is a systemic inflammatory disease, and classical disease-modifying antirheumatic drugs (cDMARDs) have proven efficacy. It is unknown what impact cDMARDs might have on dementia as an out...
Jerri D Edwards,Huiping Xu,Daniel O Clark et al.
Jerri D Edwards et al.
Introduction: Cognitive training improves cognitive performance and delays functional impairment, but its effects on dementia are not known. We examined whether three different types of cognitive training lowered the risk...
Traumatic exposures, posttraumatic stress disorder, and cognitive functioning in World Trade Center responders [0.03%]
创伤暴露、创伤后应激障碍与世界贸易中心救援人员的认知功能之间的关系
Sean Clouston,Robert H Pietrzak,Roman Kotov et al.
Sean Clouston et al.
Introduction: This study examined whether World Trade Center (WTC)-related exposures and posttraumatic stress disorder (PTSD) were associated with cognitive function and whether WTC responders' cognition differed from nor...
Proton pump inhibitors and the risk of severe cognitive impairment: The role of posttraumatic stress disorder [0.03%]
质子泵抑制剂与严重认知障碍风险的关系：创伤后应激障碍的作用
Sean A P Clouston,Oren Shapira,Roman Kotov et al.
Sean A P Clouston et al.
Introduction: Proton pump inhibitors (PPIs), a common treatment for gastroesophageal reflux disease (GERD), were recently associated with increased risk of dementia. However, severe or chronic stress including, for exampl...
Miguel Medina,Zaven S Khachaturian,Martin Rossor et al.
Miguel Medina et al.
The global strategic goal of reducing health care cost, especially the prospects for massive increases due to expanding markets for health care services demanded by aging populations and/or people with a wide range of chronic disorders-disa...