Two randomized controlled trials of SB742457 in mild-to-moderate Alzheimer's disease [0.03%]
两项有关于轻中度阿尔茨海默病的SB742457的随机对照试验
Gareth Maher-Edwards,Carolyn Watson,John Ascher et al.
Gareth Maher-Edwards et al.
Background: Two previous studies of SB742457, a 5-hydroxytryptamine (5-HT6) receptor antagonist, suggested the efficacy of improvements in cognition and global outcome in Alzheimer's disease (AD). ...
Impact of the care coordination program "Partners in Dementia Care" on veterans' hospital admissions and emergency department visits [0.03%]
老年痴呆患者协调护理计划对退伍军人医院住院和急诊就诊的影响
David M Bass,Katherine S Judge,Katie Maslow et al.
David M Bass et al.
Introduction: "Partners in Dementia Care" (PDC) tested a care-coordination program based on partnerships between Veterans Affairs (VA) medical centers and Alzheimer's Association chapters. The hypothesis posited PDC would...
Galectin-3 and incident cognitive impairment in REGARDS, a cohort of blacks and whites [0.03%]
REGARDS队列中乳糖凝集素-3与认知功能障碍发病之间的关系
Anand Venkatraman,Peter Callas,Leslie A McClure et al.
Anand Venkatraman et al.
Introduction: The relationship between serum galectin-3 and incident cognitive impairment was analyzed in the Reasons for Geographic and Racial Differences in Stroke study. ...
Alzheimer's disease Archimedes condition-event simulator: Development and validation [0.03%]
阿尔茨海默病阿基米德条件事件模拟器：开发与验证
Anuraag R Kansal,Ali Tafazzoli,K Jack Ishak et al.
Anuraag R Kansal et al.
Introduction: Several advances have been made in Alzheimer's Disease (AD) modeling, however, there remains a need for a simulator that represents the full scope of disease progression and can be used to study new disease-...
Effect of donepezil on transcranial magnetic stimulation parameters in Alzheimer's disease [0.03%]
多奈哌齐对阿尔茨海默病患者经颅磁刺激参数的影响
Yun Tae Hwang,Lorenzo Rocchi,Paul Hammond et al.
Yun Tae Hwang et al.
Introduction: There is a need for a reliable, noninvasive biomarker for Alzheimer's disease (AD). We assessed whether short-latency afferent inhibition (SAI), a transcranial magnetic stimulation paradigm that assesses cho...
Elevated phospholipase D isoform 1 in Alzheimer's disease patients' hippocampus: Relevance to synaptic dysfunction and memory deficits [0.03%]
阿尔茨海默病患者海马体中磷脂酶D同工酶1升高与突触和记忆障碍的关系
Balaji Krishnan,Rakez Kayed,Giulio Taglialatela
Balaji Krishnan
Introduction: Phospholipase D (PLD), a lipolytic enzyme that breaks down membrane phospholipids, is also involved in signaling mechanisms downstream of seven transmembrane receptors. Abnormally elevated levels of PLD acti...
Guide to enable health charities to increase recruitment to clinical trials on dementia [0.03%]
痴呆症临床试验招募受试者指南以增加健康慈善组织的参与度
Larry W Chambers,Megan Harris,Elizabeth Lusk et al.
Larry W Chambers et al.
Introduction: The Alzheimer Society embarked on a project to improve ways that the 60 provincial and local Societies in Canada can work with local researchers to support recruitment of volunteers to clinical trials and st...
Unmasking the benefits of donepezil via psychometrically precise identification of mild cognitive impairment: A secondary analysis of the ADCS vitamin E and donepezil in MCI study [0.03%]
通过心理测量学上精确的轻度认知障碍识别揭示多奈哌齐治疗获益：ADCS维生素E和多奈哌齐在轻度认知损害中研究的事后分析
Emily C Edmonds,M Colin Ard,Steven D Edland et al.
Emily C Edmonds et al.
Introduction: Criteria for mild cognitive impairment (MCI) used in many clinical trials are susceptible to "false-positive (FP)" errors that can be avoided by an actuarial psychometric approach. ...
Longitudinal patterns of potentially inappropriate medication use following incident dementia diagnosis [0.03%]
新发痴呆诊断后的潜在不适当药物使用纵向模式
Christine M Ramsey,Danijela Gnjidic,George O Agogo et al.
Christine M Ramsey et al.
Introduction: Potentially inappropriate medication (PIM) use in older adults with dementia is an understudied area. We assessed longitudinal changes in PIM exposure by dementia type following dementia diagnosis. ...
Optimizing the preclinical Alzheimer's cognitive composite with semantic processing: The PACC5 [0.03%]
通过语义处理优化阿尔茨海默病临床前认知量表：PACC5
Kathryn V Papp,Dorene M Rentz,Irina Orlovsky et al.
Kathryn V Papp et al.
Introduction: Amyloid-related decline in semantic memory was recently shown to be observable in the preclinical period of Alzheimer's disease. Cognitive composites designed to be sensitive to cognitive change in preclinic...