The Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial: A study of crenezumab versus placebo in preclinical PSEN1 E280A mutation carriers to evaluate efficacy and safety in the treatment of autosomal-dominant Alzheimer's disease, including a placebo-treated noncarrier cohort [0.03%]
针对预临床PSEN1 E280A突变携带者进行的抗β淀粉样蛋白抗体克唑单抗与安慰剂对照研究，以评估其在常染色体显性阿尔茨海默病治疗中的有效性和安全性，其中包括一个非携带者的安慰剂处理队列：阿尔茨海默预防倡议小组常染色体显性阿尔茨海默病试验
Pierre N Tariot,Francisco Lopera,Jessica B Langbaum et al.
Pierre N Tariot et al.
Introduction: Autosomal-dominant Alzheimer's disease (ADAD) represents a crucial population for identifying prevention strategies that might modify disease course for cognitively unimpaired individuals at high imminent ri...
Wishes and preferences for an online lifestyle program for brain health-A mixed methods study [0.03%]
针对脑健康在线生活项目的意愿及偏好的研究——一种混合方法的研究
Linda M P Wesselman,Ann-Katrin Schild,Nina Coll-Padros et al.
Linda M P Wesselman et al.
Introduction: Individuals with subjective cognitive decline (SCD) are at increased risk of Alzheimer's disease and could benefit from a prevention strategy targeting lifestyle factors. Making a program available through t...
"Text It" program to track falls in patients with Alzheimer's disease and dementia [0.03%]
用于阿尔茨海默病和痴呆患者跌倒追踪的"text it"项目
Rebecca J Kamil,Dara Bakar,Matthew Ehrenburg et al.
Rebecca J Kamil et al.
Introduction: Falls are a significant problem among older adults with Alzheimer's disease, leading to high rates of fracture, hospitalization, and death. Tracking falls in older adults, particularly those with cognitive i...
Donepezil may reduce the risk of comorbidities in patients with Alzheimer's disease: A large-scale matched case-control analysis in Japan [0.03%]
多奈哌齐可能降低日本阿尔茨海默病患者伴发症的风险：一项大规模病例匹配对照分析研究
Hiroyuki Kobayashi,Heii Arai
Hiroyuki Kobayashi
Introduction: Few studies have focused on the association between donepezil and physical comorbid conditions in Alzheimer's disease patients. Methods: ...
Virtual reality-based cognitive-motor training for middle-aged adults at high Alzheimer's disease risk: A randomized controlled trial [0.03%]
基于虚拟现实的认知运动训练降低中年高阿尔茨海默病风险成年人的风险：一项随机对照试验
Glen M Doniger,Michal Schnaider Beeri,Alex Bahar-Fuchs et al.
Glen M Doniger et al.
Introduction: Ubiquity of Alzheimer's disease (AD) coupled with relatively ineffectual pharmacologic treatments has spurred interest in nonpharmacologic lifestyle interventions for prevention or risk reduction. However, e...
Efficacy and safety of the compound Chinese medicine SaiLuoTong in vascular dementia: A randomized clinical trial [0.03%]
柴洛通对血管性痴呆疗效及安全性研究：一项随机临床试验
Jianping Jia,Cuibai Wei,Shuoqi Chen et al.
Jianping Jia et al.
Introduction: No licensed medications are available to treat vascular dementia (VaD). Methods: Patients were randomly assigned to exper...
Measuring cognition and function in the preclinical stage of Alzheimer's disease [0.03%]
阿尔茨海默病前期认知和功能评估方法
Sandra Weintraub,Maria C Carrillo,Sarah Tomaszewski Farias et al.
Sandra Weintraub et al.
The Alzheimer's Association's Research Roundtable met in November 2016 to explore how best to measure changes in cognition and function in the preclinical stage of Alzheimer's disease. This review will cover the tools and instruments curren...
Neuroprotective effect of a new photobiomodulation technique against Aβ25-35 peptide-induced toxicity in mice: Novel hypothesis for therapeutic approach of Alzheimer's disease suggested [0.03%]
一种新的光生物调制技术对Aβ25-35肽诱导的毒性小鼠的神经保护作用：阿尔茨海默病治疗新方法的假说
Guillaume Blivet,Johann Meunier,Francois J Roman et al.
Guillaume Blivet et al.
Introduction: Photobiomodulation was assessed as a novel treatment of Alzheimer's disease (AD) by the use of a new device RGn500 combining photonic and magnetic emissions in a mouse model of AD. ...
A simulation study comparing slope model with mixed-model repeated measure to assess cognitive data in clinical trials of Alzheimer's disease [0.03%]
斜率模型与混合模型重复测量在阿尔茨海默病认知数据评估中比较的仿真研究
Yun-Fei Chen,Xiao Ni,Adam S Fleisher et al.
Yun-Fei Chen et al.
Introduction: In clinical trials of Alzheimer's disease, a mixed-model repeated measure approach often serves as the primary analysis when evaluating disease progression; a slope model may be secondary. ...
Translational inhibition of APP by Posiphen: Efficacy, pharmacodynamics, and pharmacokinetics in the APP/PS1 mouse [0.03%]
Posiphen对APP的翻译抑制作用：在APP/PS1小鼠中的有效性和药代动力学及药效学研究
Andrew F Teich,Ekta Sharma,Eliza Barnwell et al.
Andrew F Teich et al.
Introduction: Translational inhibition of amyloid precursor protein (APP) by Posiphen has been shown to reduce APP and its fragments in cell culture, animal models, and mildly cognitively impaired patients, making it a pr...