Digital efforts in Spanish for enrolling Latino adults in the Brain Health Registry [0.03%]
针对拉丁美洲成年人在线注册“大脑健康登记系统”的数字化行动
Miriam T Ashford,Anna Aaronson,Chengshi Jin et al.
Miriam T Ashford et al.
Introduction: Previous culturally informed digital inclusion efforts in English effectively enrolled Latino adults into the Brain Health Registry (BHR), an online Alzheimer's disease (AD)-related registry. Because these e...
Recruitment and eligibility in a Phase 1 early Alzheimer's disease trial of Sabirnetug [0.03%]
Sabirnetug治疗早期阿尔茨海默病I期临床试验的受试者筛选及入组情况
Robyn Moxon,Todd Feaster,Gopalan Sethuraman et al.
Robyn Moxon et al.
Introduction: Historically underrepresented racial and ethnic groups may face a higher risk and burden of dementia but continue to be underrepresented in Alzheimer's disease (AD) clinical research. Recent efforts have bee...
Neurovascular de-coupling underlies dual-task cost across cognitive abilities [0.03%]
神经血管解耦贯穿于认知能力中的双任务损耗
Laura K Fitzgibbon-Collins,Sarah Best,Mamiko Noguchi et al.
Laura K Fitzgibbon-Collins et al.
Introduction: We tested the hypothesis that increased middle cerebral artery velocity (MCA velocity) during complex motor (overground walking) and cognitive tasks (e.g., dual task) is associated with cognitive performance...
Mitochondrial blood-based biomarker is related to cardiorespiratory fitness and aging in a sex-dependent manner [0.03%]
性别依赖型线粒体血液生物标志物与心肺功能和衰老有关
Riley E Kemna,Amanda Szabo-Reed,Hana D Mayfield et al.
Riley E Kemna et al.
Introduction: A sedentary lifestyle increases the risk for Alzheimer's disease (AD), whereas exercise has been shown to benefit brain health. Physiological factors, such as female sex, are linked to lower cardiorespirator...
Simulation of Alzheimer's diagnostic flows with blood biomarker test options in Japan [0.03%]
日本血液生物标志物检测选项模拟阿尔茨海默病诊断流程
Ataru Igarashi,Noriyuki Kimura,Takuya Ataka et al.
Ataru Igarashi et al.
Introduction: This study projected the diagnostic testing landscape for lecanemab treatment in Japan under different workflows. Methods: ...
Clinical factors predicting the rate of cognitive decline in a US memory clinic: An electronic health record study [0.03%]
基于电子健康记录的美国记忆诊所中认知下降速度的临床预测因素研究
Yuchan Wang,Qian Liu,Wenyong Li
Yuchan Wang
Clinically meaningful changes in cognitive and functional outcomes in a population-based study of cognitive aging [0.03%]
基于人群的认知衰老研究中临床意义重大的认知和功能结果变化
Jeremiah A Aakre,Anna M Castillo,Jonathan Graff-Radford et al.
Jeremiah A Aakre et al.
Introduction: Research is limited regarding meaningful change thresholds for individual patients on clinical outcome assessments (COAs) frequently used in clinical trials for Alzheimer's disease and related dementias (ADR...
Mental health counseling for caregivers is associated with a slower rate of health-care use in people with dementia [0.03%]
与痴呆症患者的照护者进行心理健康咨询与其所护理对象的医疗保健使用速度放缓有关
Mia Yang,Natasha Collier,Joseph Rigdon et al.
Mia Yang et al.
Background: Caregiver support interventions can reduce depression symptoms for caregivers of persons living with cognitive impairment and dementia (PwCI). However, few studies have assessed the effect of caregiver counsel...
Transcriptome profiling of cerebrospinal fluid in Alzheimer's disease reveals molecular dysregulations associated with disease [0.03%]
阿尔茨海默病脑脊液转录组分析揭示疾病相关分子失调
Rhys E De Sota,Bojk A Berghuis,Samantha J Khoury et al.
Rhys E De Sota et al.
Background: Despite the increasing prevalence of neurodegenerative diseases, the molecular characterization of brain pathologies remains challenging due to limited tissue access. Cerebrospinal fluid (CSF) contains a signi...
Vestibular-related dizziness duration and cognitive deficits in older adults [0.03%]
与前庭相关的头晕持续时间和老年人的认知缺陷之间的关系
Xiaobao Ma,Jiali Shen,Wei Wang et al.
Xiaobao Ma et al.
Objective: The objective of this study is to investigate the relationship between symptom duration of vestibular-related dizziness/vertigo and cognitive function in elderly patients, and to establish clinical guidance for...