Unforgettable: The power of community in the pursuit of health equity for Alzheimer's disease and other dementia [0.03%]
永恒的记忆：追求阿尔茨海默病和其他痴呆症的健康公平性的社区力量
Beverly M Berry,Garrett Davis,Yarissa Reyes et al.
Beverly M Berry et al.
Introduction: The lack of racial/ethnic and socioeconomic diversity in research is an historic and ongoing crisis, especially for diseases like Alzheimer's disease and related dementias (ADRD), whose prevalence, incidence...
Critical evaluation of real-world evidence of repurposable medicines in the Alzheimer's disease drug development pipeline using a target trial emulation [0.03%]
利用靶标试验模拟对阿尔茨海默病药物研发管线中潜在适应症药品的真实世界证据进行批判性评价
Reina Tonegawa-Kuji,Ehud Karavani,Michael Danziger et al.
Reina Tonegawa-Kuji et al.
Introduction: Repurposing Food and Drug Administration (FDA)-approved drugs could accelerate treatment development for Alzheimer's disease (AD). Methods: ...
Implementing robust amyloid PET quantification in multi-center studies: AMYPAD approach to address data acquisition, processing, interpretation and data sharing challenges [0.03%]
在多中心研究中实施稳健的淀粉样PET定量方法：AMYPAD解决数据采集、处理、解释和数据共享挑战的方法学措施
Ariane Bollack,Mahnaz Shekari,Lyduine E Collij et al.
Ariane Bollack et al.
Introduction: Amyloid-positron emission tomography (PET) is pivotal to Alzheimer's management, with the Centiloid standardizing measurements across tracers. AMYPAD trials (Diagnostic and Patient Management Study [DPMS] an...
Association between 24-h time-use composition and brain age: The IGNITE study [0.03%]
24小时时间使用构成与脑衰老之间的关联：来自IGNITE研究的证据
Audrey M Collins,Maddison L Mellow,Lu Wan et al.
Audrey M Collins et al.
Introduction: The relationships between 24-h time-use composition (i.e., sleep, sedentary behavior, light physical activity, and moderate-to-vigorous physical activity [MVPA]) and brain morphology in older adulthood remai...
Pei-Chuan Ho,Guerry M Peavy,Haeok Lee et al.
Pei-Chuan Ho et al.
Introduction: To address knowledge gaps in Alzheimer's disease (AD) research, the Asian Cohort for Alzheimer's Disease (ACAD) Study will recruit over 5000 participants of Asian descent aged 60 or older in the United State...
Immediate reactions to amyloid PET disclosure in Japanese older adults without dementia [0.03%]
日本老年非痴呆群体接受淀粉样PET检查的即刻反应
Kenichiro Sato,Yoshiki Niimi,Ryoko Ihara et al.
Kenichiro Sato et al.
Introduction: Amyloid positron emission tomography (PET) has become increasingly important for detection of early Alzheimer's disease (AD) and eligibility for emerging disease-modifying therapies. While North American and...
Electroencephalography-based signatures of cognitive resilience in individuals with stable mild cognitive impairment despite carrying a high-risk for progression to dementia [0.03%]
稳定轻度认知障碍高危患者的脑电图特征及其对痴呆进展的抵抗力标志物研究
Chiara Pappalettera,Lorenzo Nucci,Alessia Cacciotti et al.
Chiara Pappalettera et al.
Introduction: Mild cognitive impairment (MCI) represents a transitional state between normal aging and dementia, with 30%-50% of cases progressing to dementia. However, some individuals remain stable over time, even when ...
Uncovering barriers to early diagnosis of Alzheimer's disease: a European perspective [0.03%]
阿尔茨海默病早期诊断障碍的欧洲视角
David A Pérez-Martínez,Anne-Charlotte Jarry,Gabriel Martino et al.
David A Pérez-Martínez et al.
Introduction: Timely and accurate diagnosis of early Alzheimer's disease (AD) is critical to maximizing the potential benefits of disease-modifying therapies; however, it remains a challenge in clinical practice. ...
Long-term changes in cardiorespiratory fitness and incidence of Alzheimer's disease and related dementias among US Veterans [0.03%]
美国退伍军人长期心肺适能变化与阿尔茨海默病及相关痴呆症发病率之间的关系
Peter Kokkinos,Yan Cheng,Edward Zamrini et al.
Peter Kokkinos et al.
Introduction: Alzheimer's disease and related dementias (ADRD) remain a leading cause of morbidity and mortality. Poor cardiorespiratory fitness (CRF) has been identified as a potential risk factor for ADRD. Since CRF is ...
Systematic review and meta-analysis of antipsychotic discontinuation in dementia [0.03%]
系统性回顾与荟萃分析：痴呆症的抗精神病药物停药疗法
Sophie Roche,Nimesh Naran,Janneke Scholtz et al.
Sophie Roche et al.
Introduction: Antipsychotics are used to treat behavioral and psychological symptoms of dementia (BPSD). However, treatment is associated with adverse outcomes. A 2018 Cochrane review found low-quality evidence that disco...