Sex differences and the role of estrogens in the immunological underpinnings of Alzheimer's disease [0.03%]
性别差异和雌激素在阿尔茨海默病免疫机制中的作用
Brittani R Price,Keenan A Walker,Jaclyn M Eissman et al.
Brittani R Price et al.
Alzheimer's disease (AD) affects women more frequently and more severely than men, but the biological mechanisms underlying these sex differences remain poorly understood. This review integrates recent findings from neuroscience, immunology...
Health and Aging Brain Study-Health Disparities (HABS-HD) methods and partner characteristics [0.03%]
脑健康差异研究(HABS-HD)的方法及合作特点
Melissa E Petersen,Zhengyang Zhou,James R Hall et al.
Melissa E Petersen et al.
Introduction: The Health and Aging Brain Study-Health Disparities (HABS-HD) is an ongoing prospective study aimed at understanding brain health and aging. The current work provides a description of the cohort baseline cha...
More fit KL-VS heterozygotes have more favorable AD-relevant biomarker profiles [0.03%]
更符合KL的VS杂合子具有更多有利的与AD相关的生物标志物特征
Mackenzie Jarchow,Ira Driscoll,Brianne M Breidenbach et al.
Mackenzie Jarchow et al.
Introduction: Although hallmarked by β-amyloid plaques (Aβ) and neurofibrillary tangles (tau), Alzheimer's disease (AD) is a multifactorial disorder that involves neuroinflammation, neurodegeneration, and synaptic dysfu...
Utilizing MCID for evaluating clinical relevance of AD therapeutic interventions [0.03%]
利用MCID评估阿尔茨海默病治疗干预措施的临床意义
Jamie L Hamilton,Rebecca L M Fuller,Noopur Modi et al.
Jamie L Hamilton et al.
With the recent approval of disease-modifying treatments for mild cognitive impairment (MCI) and mild Alzheimer's disease (AD) by the United States Food and Drug Administration (FDA), Medicines and Healthcare products Regulatory Agency (MHR...
White matter microstructure mediates the association between cardiorespiratory fitness and cognitive performance in older adults [0.03%]
心肺适能通过白质微观结构影响老年人的认知功能
Emma M Tinney,Aaron E L Warren,Amanda O&#x;Brien et al.
Emma M Tinney et al.
Introduction: Age-related cognitive decline occurs, in part, due to diminishing white matter integrity. Higher cardiorespiratory fitness (CRF) is associated with better cognitive performance, but the neurobiological mecha...
First-in-human positron emission tomography study of intranasal insulin in aging and MCI [0.03%]
人鼻内给药胰岛素的首次人体正电子发射断层扫描研究——关于衰老和轻度认知障碍的研究
Kiran K Solingapuram Sai,Jennifer M Erichsen,Krishna K Gollapelli et al.
Kiran K Solingapuram Sai et al.
Introduction: Intranasal insulin (INI) is being explored to treat Alzheimer's disease and other conditions. The method of intranasal delivery has been shown to affect outcomes, requiring validation prior to clinical inves...
Comprehensive intervention combining group and personalized language therapy in primary progressive aphasia: Quantitative and qualitative findings [0.03%]
结合集体和个人化语言疗法的全面干预在原发性进行性失语中的应用：量化和定性结果
Tijana Simic,Laura Laird,Rudra Patel et al.
Tijana Simic et al.
Introduction: Increasingly, studies are demonstrating language and communication improvement after behavioral interventions for primary progressive aphasia (PPA), and the caregiver perspective has been highlighted as crit...
Patterns and predictors of cholinesterase inhibitor use in dementia with Lewy bodies [0.03%]
胆碱酯酶抑制剂在路易体痴呆中的使用模式及预测因素
Rachel J Heo,Ahmed Negida,Kathryn A Wyman-Chick et al.
Rachel J Heo et al.
Introduction: Current evidence supports the use of cholinesterase inhibitors (ChEIs) as the first-line symptomatic treatment for improving cognition in dementia with Lewy bodies (DLB). Little is known about current prescr...
Cognitive decline across five cognitive batteries: Sample size implications for clinical trials [0.03%]
五个认知评估量表下的认知衰退：临床试验中的样本量意义
Andrea R Zammit,Ana W Capuano,Lisa L Barnes et al.
Andrea R Zammit et al.
Introduction: We evaluated the statistical power for a theoretical randomized trial of anti-amyloid treatment in preclinical Alzheimer's Disease across five cognitive composites in preclinical Alzheimer's Disease across f...
Cardiorespiratory fitness modifies the relationship between arterial stiffness and cerebral blood flow independent of physical activity [0.03%]
有氧运动能力改变动脉僵硬度和脑血流的关系独立于体力活动
Brianne M Breidenbach,Ira Driscoll,Matthew P Glittenberg et al.
Brianne M Breidenbach et al.
Introduction: Central arterial stiffness and cerebral blood flow (CBF) are inversely related. Poor cardiorespiratory fitness (CRF) and low physical activity (PA) are related to both higher arterial stiffness and lower CBF...