Interconnected pathways: Social determinants of health, infections, and Alzheimer's disease and related dementias [0.03%]
相互关联的途径：社会决定因素、感染与阿尔茨海默病和其他痴呆症的关系
Juehyun Shin,Lavinia Alberi,Graciela Muniz-Terrera
Juehyun Shin
Social determinants of health (SDOH), infections, and Alzheimer's disease and related dementias (ADRD) are interconnected through complex pathways. Existing research establishes associations between SDOH and infections, between SDOH and ADR...
Exclusions affect representativeness of Alzheimer's disease trial participants [0.03%]
排除标准影响阿尔茨海默病临床试验参与者的代表性
Miriam T Ashford,Rachana Tank,Mohammed U Kabeto et al.
Miriam T Ashford et al.
Background: This study assessed how medical exclusion criteria of a prevention Alzheimer's disease trial impact potential eligibility and sample characteristics. ...
Interdaily variability of rest-activity patterns and risk of dementia in older adults: The ARIC Neurocognitive Study [0.03%]
社区老年人日常节律紊乱与痴呆风险的关系：来自ARIC神经认知研究的证据
Keran W Chamberlin,Lacey H Etzkorn,Anis Davoudi et al.
Keran W Chamberlin et al.
Introduction: Day-to-day variability of rest-activity patterns may have a multifaceted relationship with dementia risk, but empirical evidence is sparse. ...
Cognitive training, alone and combined with acetylcholinesterase inhibitors, in neurocognitive disorders: long-term efficacy and the role of cognitive reserve on 30 months of intervention [0.03%]
针对神经认知障碍的认知训练及其与胆碱酯酶抑制剂联合使用的长期疗效：干预30个月时认知储备的作用
Adele Ravelli,Chiara Ceolin,Marina De Rui et al.
Adele Ravelli et al.
Introduction: Non-pharmacological interventions are increasingly relevant in neurocognitive disorders (NCDs) management. Cognitive training (CT) may benefit early stages, when functional resources allow targeted stimulati...
Blood biomarkers for Alzheimer's disease are correlated with measures of agitation and cognition in a randomized trial assessing the effects of escitalopram on agitation [0.03%]
血浆生物标志物与艾司西酞普兰治疗精神疾病随机试验中躁动和认知的测量值相关性研究
Maansi Barnwal,Sheriza Baksh,Zahinoor Ismail et al.
Maansi Barnwal et al.
Introduction: Escitalopram for Agitation in Alzheimer's Disease (S-CitAD) is a National Institutes of Health-funded randomized controlled trial that randomized 173 participants with clinically diagnosed Alzheimer's diseas...
Acute anti-Aβ antibody exposure induces microglial changes and significantly alters chemokine signaling [0.03%]
急性抗Aβ抗体暴露可诱导小胶质细胞变化并显著改变趋化因子信号通路
Kate E Foley,Erica M Weekman,Donna M Wilcock
Kate E Foley
Introduction: While the anti-amyloid-lowering immunotherapies provide the first disease-targeting therapies for the treatment of Alzheimer's disease, there remain harmful adverse events causing hesitation among patients, ...
Locus coeruleus alterations in dementia with Lewy bodies: A systematic review [0.03%]
路易体痴呆蓝斑异常的系统综述研究
Anaëlle Bain,Charlotte Tomeo,Claire André et al.
Anaëlle Bain et al.
Introduction: The locus coeruleus (LC) is a small nucleus located deep within the brainstem, serving as the brain's main source of noradrenergic neurons. Through its extensive projections, it plays a critical role in regu...
Baseline characteristics from evoke and evoke+: Two phase 3 randomized placebo-controlled trials of semaglutide in participants with early-stage symptomatic Alzheimer's disease [0.03%]
Evoke和EVOKE+研究基线特征：在早期症状性阿尔茨海默病受试者中进行的司美格鲁肽三期随机双盲安慰剂对照试验的特征描述
Philip Scheltens,Alireza Atri,Howard H Feldman et al.
Philip Scheltens et al.
Introduction: The glucagon-like peptide-1 receptor agonist semaglutide may impact neuroinflammation and reduce neurodegeneration. We present baseline characteristics of participants enrolled in the evoke (NCT04777396) and...
Perception of dementia risk among Black adults: an ecological analysis of causal loop diagrams with a structural and social determinant of health composite index [0.03%]
基于健康结构和社会决定因素综合指数的因果循环图分析黑人成年人群痴呆风险感知的影响因素研究
Jean-Francois Trani,Ramkrishna K Singh,Alexis Ib Walker et al.
Jean-Francois Trani et al.
Introduction: To investigate drivers of dementia risk disparities among older Black Americans using a community-based system dynamics (CBSD) approach. Met...
Ultrasound neuromodulation as a novel dementia therapy-Investigation of possible long-term confounds [0.03%]
超声神经调控作为新型痴呆症治疗手段——调查其可能的长期影响因素
Michael Mitterwallner,Eva Matt,Robert Chen et al.
Michael Mitterwallner et al.
Introduction: Ultrasound neuromodulation has emerged as a promising adjunctive therapy in Alzheimer's disease (AD), yet a controversial issue remains: whether its reported long-term therapeutic effects could be attributed...