Bioenergetic data from a creatine monohydrate pilot trial in Alzheimer's disease [0.03%]
关于腺苷酸能参数的初步研究数据：肌酸单水合物在阿尔茨海默病中的作用
Matthew K Taylor,Aaron N Smith,In-Young Choi et al.
Matthew K Taylor et al.
Background: Creatine monohydrate (CrM) may mitigate bioenergetic failure in Alzheimer's disease (AD) by supporting ATP buffering and modulating mitochondrial function. Building upon our previous findings that CrM is assoc...
Amanda M Leisgang Osse,Yadi Zhou,Jefferson W Kinney et al.
Amanda M Leisgang Osse et al.
Biomarkers play an important role in Alzheimer's disease (AD) clinical trials in several contexts of use, including defining trial eligibility and serving as outcome measures. Utilizing clinicaltrials.gov, a registry of clinical trials, we ...
Evaluation of amyloid change as a surrogate for cognitive decline: demonstration in individual-level data from the A4 study of solanezumab [0.03%]
评估淀粉样蛋白变化作为认知下降替代指标的价值：Solanezumab治疗阿尔茨海默病4期研究个体水平数据的实证分析
Sarah F Ackley,Michael D Flanders,Audrey Murchland et al.
Sarah F Ackley et al.
Background: Differential amyloid change has served as a surrogate outcome in Alzheimer's disease trials, allowing accelerated approval of aducanumab and lecanemab. Individual-level data from the A4 study support the demon...
Effects of multidomain intervention on cognitive function in older adults with cognitive impairment: A multicenter, four-arm, cluster randomized trial [0.03%]
多领域干预对认知功能障碍老年人认知功能影响的多中心集群随机对照试验
Zhaoxue Yin,Xin Gao,Huan Yang et al.
Zhaoxue Yin et al.
Introduction: Multidomain lifestyle-based interventions seem to be effective for cognitive improvement but larger trials are limited, especially in China. This study aims to explore whether multi-domain interventions of B...
Mychael V Lourenco
Mychael V Lourenco
Impact of cognitive training on claims-based diagnosed dementia over 20 years: evidence from the ACTIVE study [0.03%]
基于保险理赔的认知障碍诊断与认知训练的20年影响：来自ACTIVE研究的证据
Norma B Coe,Katherine E M Miller,Chuxuan Sun et al.
Norma B Coe et al.
Introduction: The very long-term effect of cognitive training on the risk of Alzheimer's disease and related dementias (ADRD) is unknown. Methods: ...
Pathway-based polygenic risk of Alzheimer's disease highlights immune genes in cognitive decline [0.03%]
基于途径的阿兹海默症多基因风险揭示认知衰退的免疫基因
Emilija Romic,Ida Karlsson,Nina Karalija et al.
Emilija Romic et al.
Introduction: Alzheimer's disease (AD) is a genetically heterogeneous disease, with various genetic variants potentially influencing disease mechanisms differently. Pathway-based polygenic risk scores (p-PRS) can be used ...
Lower CD8+ T-cell senescence partially mediates the neuroprotection of higher aerobic fitness [0.03%]
较高的有氧运动健身水平的部分神经保护作用由较低的CD8⁺T细胞衰老介导
Bernadette A Fausto,Elizabeth Akbulut,Mustafa Sheikh et al.
Bernadette A Fausto et al.
Introduction: Immunosenescence - age-related changes in immunity - may exacerbate the pathologic processes of Alzheimer's disease (AD), a condition that disproportionately affects African Americans. Fortunately, a higher ...
Informing depression-specific dementia risk models: An evidence-based analysis of moderators of the depression-dementia association [0.03%]
基于对抑郁症和痴呆症关联调节因素证据的分析构建特定抑郁障碍的痴呆风险预测模型
Maha Alshahrani,Claire V Burley,Zhongyang Guan et al.
Maha Alshahrani et al.
Depression is a major modifiable risk factor for dementia, yet most prediction models treat it as a homogeneous exposure, despite evidence that risk varies among people with depression. This study aimed to identify key modifiers of the depr...
Resources for estimating dementia prevalence at the state and local levels in the United States [0.03%]
美国各州和地方估计痴呆症患病率的数据资源
Erin E Bennett,Melinda C Power
Erin E Bennett