Aβ- and tau-associated neuroinflammatory signatures in Alzheimer's disease [0.03%]
阿尔茨海默病中与Aβ和tau相关的神经炎症特征
Bruna Bellaver,Guilherme Povala,Marco Antônio De Bastiani et al.
Bruna Bellaver et al.
Introduction: Neuroinflammation is increasingly recognized as a key contributor to Alzheimer's disease (AD) progression, with distinct responses linked to amyloid beta (Aβ) and tau pathology. Two detrimental waves of neu...
Accelerometer-derived daily steps, cognition, and cognitive impairment in U.S. community-dwelling older adults: The Atherosclerosis Risk in Communities Study [0.03%]
美国社区老年人每日步数、认知能力与认知障碍：动脉粥样硬化风险社区研究中的加速度计测定结果
Pablo Martinez-Amezcua,Wuyang Zhang,Erin E Dooley et al.
Pablo Martinez-Amezcua et al.
Introduction: The relationship between daily steps and brain health is relatively underexplored, with inconsistent findings regarding the number of steps that confer cognitive benefits. ...
Study of the utility and impact of a plasma p-tau181 Alzheimer's biomarker (SUITABLE) [0.03%]
血浆p-tau181在阿尔茨海默病生物标志物中的效用和影响研究（SUITABLE）
Kyra O&#x;Brien,Cameron Coykendall,Kristin Harkins et al.
Kyra O&#x;Brien et al.
Introduction: Blood-based Alzheimer's disease (AD) biomarkers are increasingly used in clinical care, but there are few real-world studies of their clinical utility. We evaluated the impact of plasma phosphorylated tau at...
Association of Excessive Daytime Sleepiness With Long-Term Incident Dementia: The Role of β-Amyloid and White Matter Injury [0.03%]
日间过度嗜睡与长期发生性痴呆的关联：β淀粉样蛋白和白质损伤的作用
Xiaowen Zhou,Guangshi Zhang,Qili Hu et al.
Xiaowen Zhou et al.
Introduction: Excessive daytime sleepiness (EDS) is common in community-dwelling older adults, but its association with long-term incident dementia remains unclear. The roles of Alzheimer's disease (AD) pathology and vasc...
The utility of a composite endpoint for tracking disease progression in Lewy body dementia [0.03%]
复合终点在跟踪路易体痴呆疾病进展中的应用价值
Elie Matar,Simon R White,John-Paul Taylor et al.
Elie Matar et al.
Introduction: Dementia with Lewy bodies (DLB) or Parkinson's disease dementia (PDD), collectively termed Lewy body dementia (LBD), show heterogenous progression across cognitive, motor, and neuropsychiatric symptom domain...
APOE-associated disease risk and sex-specific effects in Egyptian Alzheimer's disease: an exploratory study [0.03%]
埃及阿尔茨海默病患者载脂蛋白E相关性发病风险及性别特异性影响的探索性研究
Mai Othman,Eman Khedr,Shimaa Heikal et al.
Mai Othman et al.
Introduction: The apolipoprotein E (APOE) gene is the strongest known genetic risk factor for late-onset Alzheimer's disease (AD), particularly the ε4 allele. Evidence suggests that women carrying at least one APOE ε4 a...
Economic evaluations of strategies targeting pre-diagnosis dementia populations: A systematic review [0.03%]
针对痴呆前诊断人群策略的经济学评价系统回顾
Men Thi Hoang,Alina Mona Zenker,Sanjib Saha et al.
Men Thi Hoang et al.
This review aims to appraise and summarize the best available evidence from economic evaluations (EEs) of strategies targeting populations prior to a diagnosis of dementia. A comprehensive search was conducted in EMBASE, PubMed, EconLit, We...
Worth their weight in gray matter? A narrative review of cost-effectiveness analyses of monoclonal antibodies for Alzheimer's disease [0.03%]
值其灰质之重？阿尔茨海默病单克隆抗体的成本效益分析叙述性回顾
Tuyet Thao Nguyen,Bozhidar T Chakalov,Megan Van Noord et al.
Tuyet Thao Nguyen et al.
Introduction: Monoclonal antibodies (mAbs) for Alzheimer's disease (AD) represent major therapeutic advances, but their economic value is uncertain. This review narratively examines cost-effectiveness analyses (CEAs) of a...
Peripheral immune markers in dementia: A systematic review and meta-analysis of risk, severity, and pathological correlates [0.03%]
痴呆的外周免疫标志物：风险、严重程度和病理关联的系统评价和meta分析
Ahmad A Toubasi,Thuraya N Al-Sayegh
Ahmad A Toubasi
Introduction: Systemic inflammation and innate immune activation have been implicated in dementia; however, prior studies were limited by small sample sizes. We conducted this study to evaluate the association between per...
Virtual reality-based cognitive-motor training in middle-aged adults at high Alzheimer's disease risk improves frontal cortex cerebral blood flow: A randomized controlled trial [0.03%]
基于虚拟现实的认知运动训练可改善高阿尔茨海默病风险中年人额叶血流：一项随机对照试验
Maayan Harel,Anat Leibovici,Nofar Itzhaki et al.
Maayan Harel et al.
Introduction: Alzheimer's disease (AD) pathological processes begin decades before symptom onset. Early intervention in high-risk populations may be crucial for prevention. We investigated the effect of an intervention ut...